Neuropsychological correlates of capacity determinations in alzheimer disease: Implications for assessment

American Journal of Geriatric Psychiatry

Volumn 21, Issue 4, 2013, Pages 373-381

  Palmer, Barton W ^a   Ryan, Kerry A ^b   Kim, Myra ^b   Karlawish, Jason H ^d,e   Appelbaum, Paul S ^f   Kim, Scott Y H ^b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^d Center for Bioethics   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

^f NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

Alzheimer disease; Decision making capacity; Neuropsychology

Indexed keywords

AGED; ALZHEIMER DISEASE; ARTICLE; CONCEPTUALIZATION AND INITIATION/PERSEVERATION SUBSCALE; FEMALE; HUMAN; INTERVIEW; MACARTHUR COMPETENCE ASSESSMENT TOOLECLINICAL RESEARCH; MAJOR CLINICAL STUDY; MALE; MATTIS DEMENTIA RATING SCALE; NEUROPSYCHOLOGY; PSYCHIATRIST; RANDOMIZED CONTROLLED TRIAL (TOPIC); RATING SCALE;

AGED; ALZHEIMER DISEASE; FEMALE; HUMANS; INFORMED CONSENT; MALE; MENTAL COMPETENCY; NEUROPSYCHOLOGICAL TESTS; RESEARCH SUBJECTS; THIRD-PARTY CONSENT;

EID: 84880102640     PISSN: 10647481     EISSN: 15457214     Source Type: Journal    
DOI: 10.1016/j.jagp.2012.11.008     Document Type: Article

References (33)

1. Ferri C, Prince M, Brayne C, et al: Global prevalence of dementia: a Delphi consensus study. Lancet 2005; 366:2112-2117 (Pubitemid 41797645)
2. Kim SYH: Evaluation of Capacity to Consent to Treatment and Research. New York, Oxford University Press, 2010
3. Kim SYH, Caine ED, Currier GW, et al: Assessing the competence of persons with Alzheimer's disease in providing informed consent for participation in research. Am J Psychiatry 2001; 158: 712-717 (Pubitemid 32429837)
4. Marson D, Harrell L: Executive dysfunction and loss of capacity to consent to medical treatment in patients with Alzheimer's disease. Semin Clin Neuropsychiatry 1999; 4:41-49
5. Dymek MP, Marson DC, Harrell L: Factor structure of capacity to consent to medical treatment in patients with Alzheimer's disease: an exploratory study. J Forensic Neuropsychol 1999; 1:27-48 (Pubitemid 30006307)
6. Karlawish JHT, Casarett DJ, James BD: Alzheimer's disease patients' and caregivers' capacity, competency, and reasons to enroll in an early-phase Alzheimer's disease clinical trial. J Am Geriatr Soc 2002; 50:2019-2024 (Pubitemid 35462449)
7. Earnst KS, Marson DC, Harrell LE: Cognitive models of physicians' legal standard and personal judgments of competency in patients with Alzheimer's disease. J Am Geriatr Soc 2000; 48:919-927 (Pubitemid 30637300)
8. Marson DC, Cody HA, Ingram KK, et al: Neuropsychological predictors of competency in Alzheimer's disease using a rational reasons legal standard. Arch Neurol 1995; 52:955-959
9. Moye J, Karel MJ, Gurrera RJ, et al: Neuropsychological predictors of decision-making capacity over 9 months in mild-tomoderate dementia. J Gen Intern Med 2006; 21:78-83
10. Palmer BW, Savla GN: The association of specific neuropsychological deficits with capacity to consent to research or treatment. J Int Neuropsychol Soc 2007; 13:1047-1059 (Pubitemid 47617555)
11. Palmer B, Savla G, Harmell A: Healthcare decision-making, in Civil Capacities in Clinical Neuropsychology: Research Findings and Practical Applications. Edited by Demakis G. New York, Oxford University Press, 2011, pp 69-94
12. Jefferson AL, Lambe S, Moser DJ, et al: Decisional capacity for research participation in individuals with mild cognitive impairment. J Am Geriatr Soc 2008; 56:1236-1243
13. Marson DC, Earnst KS, Jamil F, et al: Consistency of physicians' legal standard and personal judgments of competency in patients with Alzheimer's disease. J Am Geriatr Soc 2000; 48:911-918
14. Marson DC, McInturff B, Hawkins L, et al: Consistency of physician judgments of capacity to consent in mild Alzheimer's disease. J Am Geriatr Soc 1997; 45:453-457 (Pubitemid 27169221)
15. Kim SYH, Caine ED, Swan JG, et al: Do clinicians follow a risk sensitive model of capacity determination? An experimental video survey. Psychosomatics 2006; 47:325-329
16. Kim SYH, Appelbaum PS, Kim HM, et al: Variability of judgments of capacity: experience of capacity evaluators in a study of research consent capacity. Psychosomatics 2011; 52:346-353
17. Karlawish J, Kim SYH, Knopman D, et al: Interpreting the clinical significance of capacity scores for informed consent in Alzheimer disease clinical trials. Am J Geriatr Psychiatry 2008; 16:568-574
18. Kim SYH, Karlawish J, Kim HM, et al: Preservation of the capacity to appoint a proxy decision maker: implications for dementia research. Arch Gen Psychiatry 2011; 68:214-220
19. McKhann G, Drachman D, Folstein M, et al: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34:939-944 (Pubitemid 14076461)
20. Jurica PJ, Leitten CL, Mattis S: DRS-2: Dementia Rating Scale-2. Professional Manual. Lutz, FL, Psychological Resources, 2004
21. Appelbaum PS, Grisso T, Frank E, et al: Competence of depressed patients for consent to research. Am J Psychiatry 1999; 156: 1380-1384 (Pubitemid 29416534)
22. Carpenter WT Jr, Gold JM, Lahti AC, et al: Decisional capacity for informed consent in schizophrenia research. Arch Gen Psychiatry 2000; 57:533-538 (Pubitemid 30349432)
23. Appelbaum PS, Grisso T: MacCAT-CR: MacArthur Competence Assessment Tool for Clinical Research. Sarasota, FL, Professional Resource Press, 2001
24. Kim SYH, Appelbaum PS, Swan J, et al: Determining when impairment constitutes incapacity for informed consent in schizophrenia research. Br J Psychiatry 2007; 191:38-43 (Pubitemid 47035179)
25. Grisso T, Appelbaum PS: Assessing Competence to Consent to Treatment: A Guide for Physicians and Other Health Professionals. New York, Oxford University Press, 1998
26. Kim SYH: When does decisional impairment become decisional incompetence? Ethical and methodological issues in capacity research in schizophrenia. Schizophr Bull 2006; 32:92-97 (Pubitemid 43063822)
27. Marson DC, Hawkins L, McInturff B, et al: Cognitive models that predict physician judgments of capacity to consent in mild Alzheimer's disease. J Am Geriatr Soc 1997; 45:458-464 (Pubitemid 27169222)
28. Tröster AI, Butters N, Salmon DP, et al: The diagnostic utility of savings scores: differentiating Alzheimer's and Huntington's diseases with the logical memory and visual reproduction tests. J Clinical Exp Neuropsychol 1993; 15:773-788 (Pubitemid 23328973)
29. Department of Constitutional Affiars: Mental Capacity Act 2005 Code of Practice. London, England 2007
30. Rubright J, Sankar P, Casarett DJ, et al: A memory and organizational aid improves Alzheimer disease research consent capacity: results of a randomized, controlled trial. Am J Geriatr Psychiatry 2010; 18:1124-1132
31. Anastasi A, Urbina S: Psychological Testing. 7th ed, Upper Saddle River, NJ: Prentice-Hall; 1997
32. Chapman LJ, Chapman JP: Problems in the measurement of cognitive deficit. Psychol Bull 1973; 79:380-385
33. Marson DC: Loss of competency in Alzheimer's disease: conceptual and psychometric approaches. Int J Law Psychiatry 2001; 24:267-283 (Pubitemid 32611625)