메뉴 건너뛰기




Volumn 20, Issue 5, 2013, Pages 1470-1481

Regional differences in gallbladder cancer pathogenesis: Insights from a comparison of cell cycle-regulatory, PI3K, and pro-angiogenic protein expression

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENIC PROTEIN; CD1 ANTIGEN; CD31 ANTIGEN; CD34 ANTIGEN; KI 67 ANTIGEN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BCL 2; PROTEIN MDM2; PROTEIN P21; PROTEIN P27; PROTEIN P53; VASCULOTROPIN RECEPTOR 2;

EID: 84880052751     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-012-2761-0     Document Type: Article
Times cited : (10)

References (41)
  • 1
    • 49749121532 scopus 로고    scopus 로고
    • Geographic variation of gallbladder cancer mortality and risk factors in Chile: A population-based ecologic study
    • 18566990 10.1002/ijc.23662 1:CAS:528:DC%2BD1cXhtVCltL3L
    • Andia ME, Hsing AW, Andreotti G, Ferreccio C. Geographic variation of gallbladder cancer mortality and risk factors in Chile: a population-based ecologic study. Int J Cancer. 2008;123(6):1411-6.
    • (2008) Int J Cancer. , vol.123 , Issue.6 , pp. 1411-1416
    • Andia, M.E.1    Hsing, A.W.2    Andreotti, G.3    Ferreccio, C.4
  • 2
    • 54549103609 scopus 로고    scopus 로고
    • Analysis of mortality rates for gallbladder cancer across the world
    • 18982147 10.1080/13651820802007464 1:STN:280:DC%2BD1cjhsFSrtQ%3D%3D
    • Hariharan D, Saied A, Kocher HM. Analysis of mortality rates for gallbladder cancer across the world. HPB. 2008;10(5):327-31.
    • (2008) HPB , vol.10 , Issue.5 , pp. 327-331
    • Hariharan, D.1    Saied, A.2    Kocher, H.M.3
  • 4
    • 0035572863 scopus 로고    scopus 로고
    • Epidemiology and molecular pathology of gallbladder cancer
    • 11760569 10.3322/canjclin.51.6.349 1:STN:280:DC%2BD38%2FjsVOjtw%3D%3D
    • Lazcano-Ponce EC, Miquel JF, Munoz N, et al. Epidemiology and molecular pathology of gallbladder cancer. CA Cancer J Clin. 2001;51(6):349-64.
    • (2001) CA Cancer J Clin. , vol.51 , Issue.6 , pp. 349-364
    • Lazcano-Ponce, E.C.1    Miquel, J.F.2    Munoz, N.3
  • 5
    • 23344442402 scopus 로고    scopus 로고
    • Patients with gallstones develop gallbladder cancer at an earlier age
    • 16030429 10.1097/00008469-200508000-00011 1:STN:280: DC%2BD2Mznt1Wrsg%3D%3D
    • Dutta U, Nagi B, Garg PK, Sinha SK, Singh K, Tandon RK. Patients with gallstones develop gallbladder cancer at an earlier age. Eur J Cancer Prev. 2005;14(4):381-5.
    • (2005) Eur J Cancer Prev. , vol.14 , Issue.4 , pp. 381-385
    • Dutta, U.1    Nagi, B.2    Garg, P.K.3    Sinha, S.K.4    Singh, K.5    Tandon, R.K.6
  • 6
    • 0035029313 scopus 로고    scopus 로고
    • Anomalous pancreaticobiliary ductal junction without bile duct dilatation in gallbladder cancer
    • 11379314 1:STN:280:DC%2BD3M3psVSrtw%3D%3D
    • Elnemr A, Ohta T, Kayahara M, et al. Anomalous pancreaticobiliary ductal junction without bile duct dilatation in gallbladder cancer. Hepatogastroenterology. 2001;48(38):382-6.
    • (2001) Hepatogastroenterology. , vol.48 , Issue.38 , pp. 382-386
    • Elnemr, A.1    Ohta, T.2    Kayahara, M.3
  • 7
    • 34547101941 scopus 로고    scopus 로고
    • Recent trends of gallbladder cancer in Japan: An analysis of 4,770 patients
    • 17594719 10.1002/cncr.22815
    • Kayahara M, Nagakawa T. Recent trends of gallbladder cancer in Japan: an analysis of 4,770 patients. Cancer. 2007;110(3):572-80.
    • (2007) Cancer. , vol.110 , Issue.3 , pp. 572-580
    • Kayahara, M.1    Nagakawa, T.2
  • 8
    • 56349108004 scopus 로고    scopus 로고
    • Is there a role for cholecystectomy in gallbladder carcinoma discovered to be unresectable for cure at laparotomy?
    • 18836852 10.1007/s00268-008-9763-x
    • Tewari M, Kumar V, Mishra RR, Kumar M, Shukla HS. Is there a role for cholecystectomy in gallbladder carcinoma discovered to be unresectable for cure at laparotomy? World J Surg. 2008;32(12):2683-7.
    • (2008) World J Surg. , vol.32 , Issue.12 , pp. 2683-2687
    • Tewari, M.1    Kumar, V.2    Mishra, R.R.3    Kumar, M.4    Shukla, H.S.5
  • 9
    • 0032903831 scopus 로고    scopus 로고
    • Gallbladder adenomas have molecular abnormalities different from those present in gallbladder carcinomas
    • 9923922 10.1016/S0046-8177(99)90295-2 1:CAS:528:DyaK1MXhtVejurk%3D
    • Wistuba II, Miquel JF, Gazdar AF, Albores-Saavedra J. Gallbladder adenomas have molecular abnormalities different from those present in gallbladder carcinomas. Hum Pathol. 1999;30(1):21-5.
    • (1999) Hum Pathol. , vol.30 , Issue.1 , pp. 21-25
    • Wistuba, I.I.1    Miquel, J.F.2    Gazdar, A.F.3    Albores-Saavedra, J.4
  • 10
    • 33644875437 scopus 로고    scopus 로고
    • TP53 abnormalities are frequent and early events in the sequential pathogenesis of gallbladder carcinoma
    • 16177659 1:CAS:528:DC%2BD28XjtlWltbs%3D
    • Moreno M, Pimentel F, Gazdar AF, Wistuba, II, Miquel JF. TP53 abnormalities are frequent and early events in the sequential pathogenesis of gallbladder carcinoma. Ann Hepatol. 2005;4(3):192-9.
    • (2005) Ann Hepatol. , vol.4 , Issue.3 , pp. 192-199
    • Moreno, M.1    Pimentel, F.2    Gazdar, A.F.3    Wistuba, I.I.4    Miquel, J.F.5
  • 11
    • 79951937725 scopus 로고    scopus 로고
    • Mutations in the RAS/RAF/MAP kinase pathway commonly occur in gallbladder adenomas but are uncommon in gallbladder adenocarcinomas
    • 21307665 10.1097/PAI.0b013e3181f09179 1:CAS:528:DC%2BC3MXhslygurY%3D
    • Pai RK, Mojtahed K. Mutations in the RAS/RAF/MAP kinase pathway commonly occur in gallbladder adenomas but are uncommon in gallbladder adenocarcinomas. Appl Immunohistochem Mol Morphol. 2011;19(2):133-40.
    • (2011) Appl Immunohistochem Mol Morphol. , vol.19 , Issue.2 , pp. 133-140
    • Pai, R.K.1    Mojtahed, K.2
  • 12
    • 78650610356 scopus 로고    scopus 로고
    • Gallbladder cancer: Differences in presentation, surgical treatment, and survival in patients treated at centers in three countries
    • 21075015 10.1016/j.jamcollsurg.2010.09.009
    • Butte JM, Matsuo K, Gonen M, et al. Gallbladder cancer: differences in presentation, surgical treatment, and survival in patients treated at centers in three countries. J Am Coll Surg. 2011;212(1):50-61.
    • (2011) J Am Coll Surg. , vol.212 , Issue.1 , pp. 50-61
    • Butte, J.M.1    Matsuo, K.2    Gonen, M.3
  • 13
    • 0035954129 scopus 로고    scopus 로고
    • Allelotype analysis of gallbladder carcinoma associated with anomalous junction of pancreaticobiliary duct
    • 11311485 10.1016/S0304-3835(01)00436-0 1:CAS:528:DC%2BD3MXislGku78%3D
    • Nakayama K, Konno M, Kanzaki A, et al. Allelotype analysis of gallbladder carcinoma associated with anomalous junction of pancreaticobiliary duct. Cancer Lett. 2001;166(2):135-41.
    • (2001) Cancer Lett. , vol.166 , Issue.2 , pp. 135-141
    • Nakayama, K.1    Konno, M.2    Kanzaki, A.3
  • 14
    • 0032976479 scopus 로고    scopus 로고
    • Gene mutations of K-ras in gallbladder mucosae and gallbladder carcinoma with an anomalous junction of the pancreaticobiliary duct
    • 10364037 10.1111/j.1572-0241.1999.01155.x 1:CAS:528:DyaK1MXktVKnu7k%3D
    • Hanada K, Tsuchida A, Iwao T, et al. Gene mutations of K-ras in gallbladder mucosae and gallbladder carcinoma with an anomalous junction of the pancreaticobiliary duct. Am J Gastroenterol. 1999;94(6):1638-42.
    • (1999) Am J Gastroenterol. , vol.94 , Issue.6 , pp. 1638-1642
    • Hanada, K.1    Tsuchida, A.2    Iwao, T.3
  • 15
    • 0033286201 scopus 로고    scopus 로고
    • Cellular kinetics and gene mutations in gallbladder mucosa with an anomalous junction of pancreaticobiliary duct
    • 10526056 10.1007/s005340050111 1:STN:280:DyaK1MvlsleitQ%3D%3D
    • Hanada K, Tsuchida A, Kajiyama G. Cellular kinetics and gene mutations in gallbladder mucosa with an anomalous junction of pancreaticobiliary duct. J Hepatobiliary Pancreat Surg. 1999;6(3):223-8.
    • (1999) J Hepatobiliary Pancreat Surg. , vol.6 , Issue.3 , pp. 223-228
    • Hanada, K.1    Tsuchida, A.2    Kajiyama, G.3
  • 16
    • 0029864322 scopus 로고    scopus 로고
    • P53 protein overexpression in gallbladder carcinoma and its precursor lesions: An immunohistochemical study
    • 8617479 10.1016/S0046-8177(96)90109-4 1:STN:280:DyaK287osFagsA%3D%3D
    • Wistuba II, Gazdar AF, Roa I, Albores-Saavedra J. p53 protein overexpression in gallbladder carcinoma and its precursor lesions: an immunohistochemical study. Hum Pathol. 1996;27(4):360-5.
    • (1996) Hum Pathol. , vol.27 , Issue.4 , pp. 360-365
    • Wistuba, I.I.1    Gazdar, A.F.2    Roa, I.3    Albores-Saavedra, J.4
  • 17
    • 0031950070 scopus 로고    scopus 로고
    • Mutations of p53 in gallbladder carcinomas in high-incidence areas of Japan and Chile
    • 9568784 1:CAS:528:DyaK1cXlvFOnur4%3D
    • Yokoyama N, Hitomi J, Watanabe H, et al. Mutations of p53 in gallbladder carcinomas in high-incidence areas of Japan and Chile. Cancer Epidemiol Biomarkers Prev. 1998;7(4):297-301.
    • (1998) Cancer Epidemiol Biomarkers Prev. , vol.7 , Issue.4 , pp. 297-301
    • Yokoyama, N.1    Hitomi, J.2    Watanabe, H.3
  • 18
    • 18544407444 scopus 로고    scopus 로고
    • TP53 mutations in stage i gallbladder carcinoma with special attention to growth patterns
    • 9376195 10.1016/S0959-8049(97)00080-4 1:CAS:528:DyaK2sXkslOisb0%3D
    • Hanada K, Itoh M, Fujii K, et al. TP53 mutations in stage I gallbladder carcinoma with special attention to growth patterns. Eur J Cancer. 1997;33(7):1136-40.
    • (1997) Eur J Cancer. , vol.33 , Issue.7 , pp. 1136-1140
    • Hanada, K.1    Itoh, M.2    Fujii, K.3
  • 19
    • 68749104995 scopus 로고    scopus 로고
    • Gallbladder cancer: A morphological and molecular update
    • 19490172 10.1111/j.1365-2559.2008.03192.x
    • Goldin RD, Roa JC. Gallbladder cancer: a morphological and molecular update. Histopathology. 2009;55(2):218-29.
    • (2009) Histopathology. , vol.55 , Issue.2 , pp. 218-229
    • Goldin, R.D.1    Roa, J.C.2
  • 20
    • 54849422245 scopus 로고    scopus 로고
    • Role of tumor angiogenesis in gallbladder carcinoma: With special reference to thymidine phosphorylase
    • 18946757 10.1007/s10147-008-0778-y 1:CAS:528:DC%2BD1cXht1Oktr3K
    • Harino Y, Imura S, Kanemura H, et al. Role of tumor angiogenesis in gallbladder carcinoma: with special reference to thymidine phosphorylase. Int J Clin Oncol. 2008;13(5):452-7.
    • (2008) Int J Clin Oncol. , vol.13 , Issue.5 , pp. 452-457
    • Harino, Y.1    Imura, S.2    Kanemura, H.3
  • 21
    • 33644972080 scopus 로고    scopus 로고
    • Differential cell cycle-regulatory protein expression in biliary tract adenocarcinoma: Correlation with anatomic site, pathologic variables, and clinical outcome
    • 16505435 10.1200/JCO.2005.04.6631 1:CAS:528:DC%2BD28XislGgsbY%3D
    • Jarnagin WR, Klimstra DS, Hezel M, et al. Differential cell cycle-regulatory protein expression in biliary tract adenocarcinoma: correlation with anatomic site, pathologic variables, and clinical outcome. J Clin Oncol. 2006;24(7):1152-60.
    • (2006) J Clin Oncol. , vol.24 , Issue.7 , pp. 1152-1160
    • Jarnagin, W.R.1    Klimstra, D.S.2    Hezel, M.3
  • 22
    • 79551682846 scopus 로고    scopus 로고
    • Mutational profiling reveals PIK3CA mutations in gallbladder carcinoma
    • 21303542 10.1186/1471-2407-11-60
    • Deshpande V, Nduaguba A, Zimmerman SM, et al. Mutational profiling reveals PIK3CA mutations in gallbladder carcinoma. BMC Cancer. 2011;11:60.
    • (2011) BMC Cancer. , vol.11 , pp. 60
    • Deshpande, V.1    Nduaguba, A.2    Zimmerman, S.M.3
  • 23
    • 79959674738 scopus 로고    scopus 로고
    • The role of laparoscopic staging in patients with incidental gallbladder cancer
    • 21689230 10.1111/j.1477-2574.2011.00325.x
    • Butte JM, Gonen M, Allen PJ, et al. The role of laparoscopic staging in patients with incidental gallbladder cancer. HPB. 2011;13(7):463-72.
    • (2011) HPB , vol.13 , Issue.7 , pp. 463-472
    • Butte, J.M.1    Gonen, M.2    Allen, P.J.3
  • 25
    • 77955592507 scopus 로고    scopus 로고
    • 7 ed Chicago: American Joint Committee on Cancer
    • AJCC Cancer Staging Handbook. 7 ed. Chicago: American Joint Committee on Cancer; 2010.
    • (2010) AJCC Cancer Staging Handbook
  • 26
    • 77954144291 scopus 로고    scopus 로고
    • Protocol for PTEN expression by immunohistochemistry in formalin-fixed paraffin-embedded human breast carcinoma
    • 20216404 10.1097/PAI.0b013e3181d50bd5 1:CAS:528:DC%2BC3cXnvVOltb8%3D
    • Sakr RA, Barbashina V, Morrogh M, et al. Protocol for PTEN expression by immunohistochemistry in formalin-fixed paraffin-embedded human breast carcinoma. Appl Immunohistochem Mol Morphol. 2010;18(4):371-4.
    • (2010) Appl Immunohistochem Mol Morphol. , vol.18 , Issue.4 , pp. 371-374
    • Sakr, R.A.1    Barbashina, V.2    Morrogh, M.3
  • 27
    • 0034050388 scopus 로고    scopus 로고
    • TP53 mutations and mdm2 protein overexpression in cholangiocarcinomas
    • Della Torre G, Pasquini G, Pilotti S, et al. TP53 mutations and mdm2 protein overexpression in cholangiocarcinomas. Diagn Mol Pathol. 2000;9(1):41-6.
    • (2000) Diagn Mol Pathol , vol.9 , Issue.1 , pp. 41-46
    • Della Torre, G.1    Pasquini, G.2    Pilotti, S.3
  • 28
    • 0032874377 scopus 로고    scopus 로고
    • Protein expression and genetic alterations of p53 and ras in intrahepatic cholangiocarcinoma
    • 10469215 10.1046/j.1365-2559.1999.00705.x 1:STN:280:DyaK1MzpvVeqsg%3D%3D
    • Furubo S, Harada K, Shimonishi T, Katayanagi K, Tsui W, Nakanuma Y. Protein expression and genetic alterations of p53 and ras in intrahepatic cholangiocarcinoma. Histopathology. 1999;35(3):230-40.
    • (1999) Histopathology. , vol.35 , Issue.3 , pp. 230-240
    • Furubo, S.1    Harada, K.2    Shimonishi, T.3    Katayanagi, K.4    Tsui, W.5    Nakanuma, Y.6
  • 29
    • 0033916770 scopus 로고    scopus 로고
    • Bcl-2 expression in cholangiocellular carcinoma is inversely correlated with biologically aggressive phenotypes
    • 10895069 10.1159/000012139 1:CAS:528:DC%2BD3cXls1Gms7w%3D
    • Ito Y, Takeda T, Sasaki Y, et al. Bcl-2 expression in cholangiocellular carcinoma is inversely correlated with biologically aggressive phenotypes. Oncology. 2000;59(1):63-7.
    • (2000) Oncology. , vol.59 , Issue.1 , pp. 63-67
    • Ito, Y.1    Takeda, T.2    Sasaki, Y.3
  • 30
    • 0035024034 scopus 로고    scopus 로고
    • Expression and clinical significance of the G1-S modulators in intrahepatic cholangiocellular carcinoma
    • 11340376 10.1159/000055325 1:CAS:528:DC%2BD3MXjvVWqtLo%3D
    • Ito Y, Takeda T, Sasaki Y, et al. Expression and clinical significance of the G1-S modulators in intrahepatic cholangiocellular carcinoma. Oncology. 2001;60(3):242-51.
    • (2001) Oncology. , vol.60 , Issue.3 , pp. 242-251
    • Ito, Y.1    Takeda, T.2    Sasaki, Y.3
  • 31
    • 0033986568 scopus 로고    scopus 로고
    • Prognostic significance of p27(kip1) protein expression and spontaneous apoptosis in patients with colorectal adenocarcinomas
    • 10644940 10.1159/000012078 1:CAS:528:DC%2BD3cXht1aqsb4%3D
    • Tenjo T, Toyoda M, Okuda J, et al. Prognostic significance of p27(kip1) protein expression and spontaneous apoptosis in patients with colorectal adenocarcinomas. Oncology. 2000;58(1):45-51.
    • (2000) Oncology. , vol.58 , Issue.1 , pp. 45-51
    • Tenjo, T.1    Toyoda, M.2    Okuda, J.3
  • 33
    • 33644848963 scopus 로고    scopus 로고
    • Gallbladder cancer worldwide: Geographical distribution and risk factors
    • 16397865 10.1002/ijc.21683 1:CAS:528:DC%2BD28XislKlsrw%3D
    • Randi G, Franceschi S, La Vecchia C. Gallbladder cancer worldwide: geographical distribution and risk factors. Int J Cancer. 2006;118(7):1591-602.
    • (2006) Int J Cancer. , vol.118 , Issue.7 , pp. 1591-1602
    • Randi, G.1    Franceschi, S.2    La Vecchia, C.3
  • 34
    • 53449088603 scopus 로고    scopus 로고
    • Gallbladder cancer incidence among American Indians and Alaska Natives, US, 1999-2004
    • 18720382 10.1002/cncr.23737
    • Lemrow SM, Perdue DG, Stewart SL, et al. Gallbladder cancer incidence among American Indians and Alaska Natives, US, 1999-2004. Cancer. 2008;113(5 Suppl):1266-73.
    • (2008) Cancer. , vol.113 , Issue.5 SUPPL. , pp. 1266-1273
    • Lemrow, S.M.1    Perdue, D.G.2    Stewart, S.L.3
  • 35
    • 0027411252 scopus 로고
    • Association between gallbladder cancer and anomalous union of the pancreaticobiliary ductal system
    • 8462931 1:STN:280:DyaK3s3hs1aisA%3D%3D
    • Mori K, Nagakawa T, Ohta T, et al. Association between gallbladder cancer and anomalous union of the pancreaticobiliary ductal system. Hepatogastroenterology. 1993;40(1):56-60.
    • (1993) Hepatogastroenterology. , vol.40 , Issue.1 , pp. 56-60
    • Mori, K.1    Nagakawa, T.2    Ohta, T.3
  • 36
    • 0032197092 scopus 로고    scopus 로고
    • The cell cycle: A review
    • 9823588 10.1177/030098589803500601 1:CAS:528:DyaK1cXns1SktLk%3D
    • Schafer KA. The cell cycle: a review. Vet Pathol. 1998;35(6):461-78.
    • (1998) Vet Pathol. , vol.35 , Issue.6 , pp. 461-478
    • Schafer, K.A.1
  • 37
    • 0038052805 scopus 로고    scopus 로고
    • The cell cycle: A review of regulation, deregulation and therapeutic targets in cancer
    • 12814430 10.1046/j.1365-2184.2003.00266.x 1:CAS:528:DC%2BD3sXmtVOitr4%3D
    • Vermeulen K, Van Bockstaele DR, Berneman ZN. The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer. Cell Prolif. 2003;36(3):131-49.
    • (2003) Cell Prolif. , vol.36 , Issue.3 , pp. 131-149
    • Vermeulen, K.1    Van Bockstaele, D.R.2    Berneman, Z.N.3
  • 38
    • 64949156435 scopus 로고    scopus 로고
    • The prognostic value of angiogenesis by Chalkley counting in gallbladder carcinoma
    • 19453024
    • da Rocha AO, Coutinho LM, Schall JG. The prognostic value of angiogenesis by Chalkley counting in gallbladder carcinoma. Hepatogastroenterology. 2009;56(89):34-8.
    • (2009) Hepatogastroenterology. , vol.56 , Issue.89 , pp. 34-38
    • Da Rocha, A.O.1    Coutinho, L.M.2    Schall, J.G.3
  • 39
    • 32944482803 scopus 로고    scopus 로고
    • Molecular context of the EGFR mutations: Evidence for the activation of mTOR/S6K signaling
    • 16467080 10.1158/1078-0432.CCR-05-1362 1:CAS:528:DC%2BD28XhtFeitbw%3D
    • Conde E, Angulo B, Tang M, et al. Molecular context of the EGFR mutations: evidence for the activation of mTOR/S6K signaling. Clin Cancer Res. 2006;12(3 Pt 1):710-7.
    • (2006) Clin Cancer Res. , vol.12 , Issue.3 PART 1 , pp. 710-717
    • Conde, E.1    Angulo, B.2    Tang, M.3
  • 40
    • 51849086880 scopus 로고    scopus 로고
    • PTEN: A new guardian of the genome
    • 18794879 10.1038/onc.2008.241 1:CAS:528:DC%2BD1cXhtFWiurzP
    • Yin Y, Shen WH. PTEN: a new guardian of the genome. Oncogene. 2008;27(41):5443-53.
    • (2008) Oncogene. , vol.27 , Issue.41 , pp. 5443-5453
    • Yin, Y.1    Shen, W.H.2
  • 41
    • 79952851688 scopus 로고    scopus 로고
    • Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers
    • 21425139 10.1002/cncr.25630 1:CAS:528:DC%2BC3MXkslWiu7s%3D
    • Baba Y, Nosho K, Shima K, et al. Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers. Cancer. 2011;117(7):1399-408.
    • (2011) Cancer. , vol.117 , Issue.7 , pp. 1399-1408
    • Baba, Y.1    Nosho, K.2    Shima, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.