Analysis of polymorphic residues reveals distinct enzymatic and cytotoxic activities of the streptococcus pyogenes NAD+ glycohydrolase

Journal of Biological Chemistry

Volumn 288, Issue 27, 2013, Pages 20064-20075

  Chandrasekaran, Sukantha ^a   Ghosh, Joydeep ^a,b   Port, Gary C ^a   Koh, Eun Ik ^a   Caparon, Michael G ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL CELLS; CYTOTOXIC ACTIVITIES; EPITHELIAL CELLS; GLYCOHYDROLASE; GLYCOSIDIC BOND; INACTIVE VARIANTS; SIMILAR PATTERN; STREPTOCOCCUS PYOGENES;

AMINO ACIDS; CELL DEATH;

CYTOTOXICITY;

ADENOSINE DIPHOSPHATE RIBOSE; BACTERIAL ENZYME; GLYCOSIDASE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE NUCLEOSIDASE;

AMINO ACID SEQUENCE; ARTICLE; CELL CULTURE; CHEMICAL BOND; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME MODIFICATION; ENZYME POLYMORPHISM; ENZYME STRUCTURE; EPITHELIUM CELL; GLYCOSIDIC BOND; MOLECULAR EVOLUTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; STREPTOCOCCUS PYOGENES;

ALLELIC VARIATION; BACTERIA; BACTERIAL PATHOGENESIS; BACTERIAL TOXINS; CELL DEATH; CYTOTOXICITY; ENZYMES; GROUP A STREPTOCOCCUS; NAD+ GLYCOHYDROLASE;

ADENOSINE DIPHOSPHATE; BACTERIAL PROTEINS; CELL LINE; EPITHELIAL CELLS; HUMANS; NAD; NAD+ NUCLEOSIDASE; SPECIES SPECIFICITY; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS PYOGENES;

EID: 84880049908     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.481556     Document Type: Article

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