Determination of diuretics and laxatives as adulterants in herbal formulations for weight loss

Food Additives and Contaminants - Part A

Volumn 30, Issue 7, 2013, Pages 1230-1237

  Moreira, Ana Paula Lançanova ^a   Motta, Monique Jung ^a   Dal Molin, Thaís Ramos ^a   Viana, Carine ^a   de Carvalho, Leandro Machado ^a  

^a FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

Author keywords

adulterants; capillary zone electrophoresis; conductivity detection; herbal formulations

Indexed keywords

CHEMICAL CONTAMINATION; FOOD ADDITIVES;

ADULTERANTS; CAPACITIVELY COUPLED CONTACTLESS CONDUCTIVITY DETECTION; CAPILLARY ZONE ELECTROPHORESIS; CHLORTHALIDONE; CONDUCTIVITY DETECTION; HERBAL FORMULATIONS; HYDROCHLOROTHIAZIDE; NATURAL PRODUCTS;

CAPILLARY ELECTROPHORESIS;

AMFEPRAMONE; AMILORIDE; CHLORTALIDONE; DIURETIC AGENT; FLUOXETINE; FUROSEMIDE; HYDROCHLOROTHIAZIDE; LAXATIVE; PAROXETINE; PHENOLPHTHALEIN;

ARTICLE; CAPILLARY ZONE ELECTROPHORESIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG DETERMINATION; PH; PRIORITY JOURNAL; WEIGHT REDUCTION;

EID: 84880044383     PISSN: 19440049     EISSN: 14645122     Source Type: Journal    
DOI: 10.1080/19440049.2013.800649     Document Type: Article

References (22)

1. Almeida AE, Ribeiro ML, Polese L. 2000. Determination of amfepramone hydrochloride, fenproporex and diazepam in so-called "natural" capsules used in the treatment of obesity. J Liq Chrom Relat Technol. 23:1109-1118.
2. Al-Safi SA, Ayoub NM, Ayoub AM, Al-Momany E, Al-Doghim I, Al-Balas M, Alkofahi AS, Aboul-Enein FH, Aboul-Enein BH. 2008. Public awareness of the abuse of herbs and drugs to decrease body weight: a novel survey in Jordan. Am J Public Health. 16:205-213.
3. Bogusz MJ, Hassan H, Al-Enazi E, Ibrahim Z, AL-tufail M. 2006. Application of LC-ESI-MS-MS for detection of synthetic adulterants in herbal remedies. J Pharm Biomed Anal. 41:554-564.
4. Carvalho LM, Cohen P, Silva CV, Moreira APL, Falcão T, Dal Molin T, Zemolin G, Martini M. 2012. A new approach to determining pharmacologic adulteration of herbal weight loss products. Food Addit Contam: Part A. 29:1661-1667.
5. Carvalho LM, Martini M, Moreira APL, Garcia SC, Nascimento PC, Bohrer D. 2010. Determination of synthetic pharmaceuticals in phytotherapeutics by capillary zone electrophoresis with contactless conductivity detection (CZE-C4D). Microchem J. 96:114-119.
6. Carvalho LM, Martini M, Moreira APL, Lima APS, Correia D, Falcão T, Garcia SC, Bairros AV, Nascimento PC, Bohrer D. 2011. Presence of synthetic pharmaceuticals as adulterants in slimming phytotherapeutic formulations and their analytical determination. Forensic Sci Int. 204:6-12.
7. Carvalho LM, Moreira APL, Martini M, Falcão T. 2011. The illegal use of synthetic pharmaceuticals in herbal formulations: an overview of adulteration practices and analytical investigations. Forensic Sci Rev. 23:73-90.
8. Carvalho LM, Spengler C, de Lima APS, Raabe A, Martini M, do Nascimento PC, Bohrer D. 2009. Determinação simultânea de cátions empregando eletroforese capilar com detecção sem contato em equipamento construído em laboratório. Quim Nova. 32:2203-2208.
9. Cianchino V, Acosta G, Ortega C, Martínez LD, Gómez MR. 2008. Analysis of potential adulteration in herbal medicines and dietary supplements for the weight control by capillary electrophoresis. Food Chem. 108:1075-1081.
10. Corns C, Metcalfe KJ. 2002. Risks associated with herbal slimming remedies. J Roy Soc Promot Health. 122:213-219.
11. Ernst E. 2001. Toxic heavy metals and undeclared drugs in Asian herbal medicines. Trends Pharmacol Sci. 23:136-139.
12. Ernst E. 2002. Adulteration of Chinese herbal medicines with synthetic drugs: a systematic review. Eur J Intern Med. 252:107-113.
13. Ernst E. 2012. Risks associated with complementary therapies. In: Dukes MNG, Aronson JK, editors. Meyler's side effects of drugs. Amsterdam: Elsevier; p. 1649-1681.
14. Ernst E, White A. 2000. The BBC survey of complementary medicine use in the UK. Complement Ther Med. 8:32-36.
15. Kanan S, Abu-Yousef IA, Gunasekar C, Abd N, Narasimhan S. 2009. Detection and quantification of synthetic drugs in herbal slimming formula. Eur J Sci Res. 34:348-357.
16. Kubán P, Hauser PC. 2008. A review of the recent achievements in capacitively coupled contactless conductivity detection. Anal Chim Acta. 607:15-29.
17. Liang Q, Qu J, Luo G, Wang YW. 2006. Rapid and reliable determination of illegal adulterant in herbal medicines and dietary supplements by LC/MS/MS. J Pharm Biomed Anal. 40:305-311.
18. Müller D, Weinmann W, Hermanns-Clausen M. 2009. Chinese slimming capsules containing sibutramine sold over the internet - a case series. Dtsch Arztebl Int. 106:218-222.
19. RIVM Report 370030002. 2009. Trends in drug substances detected in illegal weight-loss medicines and dietary supplements. A 2002-2007 survey and health risk analysis [Internet]. [cited 2013 June 12]. Available from: http://www.rivm.nl/bibliotheek/rapporten/370030002.pdf
20. Silva JAF. 2003. Detecção em eletroforese capilar. Quim Nova. 26:56-64.
21. Sombra LL, Gómez MR, Olsina R, Martínez LDM, Silva MF. 2005. Comparative study between capillary electrophoresis and high performance liquid chromatography in "guarana" based phytopharmaceuticals. J Pharm Biomed Anal. 36:989-994.
22. Tavares MFM. 1997. Mecanismos de separação em eletroforese capilar. Quim Nova. 20:493-510.