An evaluation of the non-invasive faecal pellet assessment method as an early drug discovery screen for gastrointestinal liability

Journal of Pharmacological and Toxicological Methods

Volumn 68, Issue 1, 2013, Pages 123-136

  Marks, Louise ^a   Beard, Elizabeth ^a   Cobey, Des ^a   Moore, Nick ^a   Motyer, Victoria ^a   Valentin, Jean Pierre ^a   Ewart, Lorna ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Charcoal meal; Faecal pellet; Gastric emptying; Gastrointestinal adverse effects; Gastrointestinal safety liability; Methods; Non invasive screen; Pellet transit; Small intestinal transit

Indexed keywords

AMPHETAMINE; ATROPINE; BACLOFEN; BETHANECHOL; CHARCOAL; CLONIDINE; LOPERAMIDE; METOCLOPRAMIDE; QUININE; THEOPHYLLINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY PLETHYSMOGRAPHY; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG TOXICITY; FEASIBILITY STUDY; FECES; FEMALE; GASTROINTESTINAL TOXICITY; GASTROINTESTINAL TRANSIT; INTERMETHOD COMPARISON; MALE; NON INVASIVE MEASUREMENT; NONHUMAN; RAT; SCREENING TEST; SINGLE DRUG DOSE; STOMACH EMPTYING; WEIGHT;

ADRS; ADVERSE DRUG REACTIONS; ADVERSE EFFECTS; AES; BPM; BREATHS PER MINUTE; CHARCOAL MEAL; DOSE RANGE FINDING; DRF; FAECAL PELLET; GASTRIC EMPTYING; GASTROINTESTINAL; GASTROINTESTINAL ADVERSE EFFECTS; GASTROINTESTINAL SAFETY LIABILITY; GI; ICH; INTERNATIONAL CONFERENCE ON HARMONISATION; MAXIMUM TOLERATED DOSE; METHODS; MINUTE VOLUME; MTD; MV; NON-INVASIVE SCREEN; NON-STEROIDAL ANTI-INFLAMMATORY DRUGS; NSAID; PELLET TRANSIT; RESPIRATORY RATE; RR; SC; SMALL INTESTINAL TRANSIT; SUBCUTANEOUS; TIDAL VOLUME; TV; WBP; WHOLE BODY PLETHYSMOGRAPHY;

ANIMALS; DRUG DESIGN; FEASIBILITY STUDIES; FECES; FEMALE; GASTRIC EMPTYING; GASTROINTESTINAL TRACT; GASTROINTESTINAL TRANSIT; MALE; PLETHYSMOGRAPHY, WHOLE BODY; RATS; RATS, WISTAR; TIME FACTORS; TOXICITY TESTS;

RATTUS; RATTUS NORVEGICUS;

EID: 84880041722     PISSN: 10568719     EISSN: 1873488X     Source Type: Journal    
DOI: 10.1016/j.vascn.2013.03.006     Document Type: Article

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