Microbiology of bacteria causing recurrent acute otitis media (AOM) and AOM treatment failure in young children in Spain: Shifting pathogens in the post-pneumococcal conjugate vaccination era

International Journal of Pediatric Otorhinolaryngology

Volumn 77, Issue 8, 2013, Pages 1231-1236

  Pumarola, Felix ^a,b   Marès, Josep ^c   Losada, Isabel ^d   Minguella, Isabel ^e   Moraga, Fernando ^a,b   Tarragó, David ^f   Aguilera, Ulla ^g   Casanovas, Josep M ^h   Gadea, Gloria ⁱ   Trías, Elisenda ^g   Cenoz, Santiago ^j   Sistiaga, Alessandra ^j   García Corbeira, Pilar ^j   Pirçon, Jean Yves ^k   Marano, Cinzia ^k   Hausdorff, William P ^k  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^b Vall d'Hebron Institute of Research (VHIR)   (Spain)

^c Institut Pediatric Mares Riera   (Spain)

^d CAP Sans   (Spain)

^e CAP Sanllehy   (Spain)

^f INSTITUTO DE SALUD CARLOS III   (Spain)

^g CAP Sant Andreu   (Spain)

^h CAP Roquetes Canteres   (Spain)

ⁱ CAP Pare Claret   (Spain)

^j GLAXOSMITHKLINE   (Spain)

^k GSK   (Belgium)

more..

Author keywords

Antibiotic resistance; Haemophilus influenzae; Otitis media; Streptococcus pneumoniae; Tympanocentesis

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; AMPICILLIN; PNEUMOCOCCUS VACCINE;

ACUTE OTITIS MEDIA; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM CULTURE; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATE; CHILD; CONTROLLED STUDY; DRUG TREATMENT FAILURE; FEMALE; HAEMOPHILUS INFLUENZAE; HUMAN; INFANT; INFECTION PREVENTION; MAJOR CLINICAL STUDY; MALE; MORAXELLA CATARRHALIS; MULTIDRUG RESISTANCE; MYRINGOTOMY; NEISSERIA; NONHUMAN; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEUS; PSEUDOMONAS; SPAIN; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES; VACCINE FAILURE;

ANTIBIOTIC RESISTANCE; HAEMOPHILUS INFLUENZAE; OTITIS MEDIA; STREPTOCOCCUS PNEUMONIAE; TYMPANOCENTESIS;

ACUTE DISEASE; ANTI-BACTERIAL AGENTS; CHILD, PRESCHOOL; DRUG RESISTANCE, MICROBIAL; FEMALE; HAEMOPHILUS INFLUENZAE; HUMANS; INFANT; MALE; MICROBIAL SENSITIVITY TESTS; MORAXELLA (BRANHAMELLA) CATARRHALIS; OTITIS MEDIA; PNEUMOCOCCAL VACCINES; PROSPECTIVE STUDIES; RECURRENCE; SPAIN; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES; TREATMENT FAILURE;

EID: 84880038025     PISSN: 01655876     EISSN: 18728464     Source Type: Journal    
DOI: 10.1016/j.ijporl.2013.04.002     Document Type: Article

References (37)

1. Teele D.W., Klein J.O., Rosner B. Epidemiology of otitis media during the first seven years of life in children in greater Boston: a prospective, cohort study. J. Infect. Dis. 1989, 160:83-94.
2. Klein J.O. The burden of otitis media. Vaccine 2000, 19(Suppl. (1)):S2-S8.
3. Liese J., Silfverdal S.A., Giaquinto C., Carmona A., Larcombe J., Garcia-Sicilia J., et al. Incidence of acute otitis media in European children under 5 years: results of a prospective observational cohort study. Abstract. 29th Annual meeting of the European Society for Paediatric Infectious Diseases (ESPID) 2011, http://www.kenes.com/espid2011/cd/pdf/O146.pdf.
4. Garcés-Sánchez M., Díez-Domingo J., Alvarez de Labiada T., Planelles V., Graullera M., Baldo J.M., et al. Epidemiology and burden of acute otitis media in Valencia (Spain). Ann. Pediatr. (Barc). 2004, 60:125-132.
5. Riquelme Pérez M., Rincón Víctor P., García Ruiz L., Tusset Castellano J., Bravo Tabares R., Fernández Pérez C. Acute otitis media in a pediatric primary care unit. Ann. Pediatr. (Barc). 2004, 61:408-412.
6. de Miguel Martínez I., Ramos Macías A. Serotypes of Streptococcus pneumoniae isolated from children with acute otitis media. Enferm. Infecc. Microbiol. Clin. 2009, 27:61-62.
7. del Castillo F., Baquero-Artigao F., Garcia-Perea A. Influence of recent antibiotic therapy on antimicrobial resistance of Streptococcus pneumoniae in children with acute otitis media in Spain. Pediatr. Infect. Dis. J. 1998, 17:94-97.
8. Gené A., García-García J.J., Domingo A., Wienberg P., Palacín E. Etiology of acute otitis media in a children's hospital and antibiotic sensitivity of the bacteria involved. Enferm. Infecc. Microbiol. Clin. 2004, 22:377-380.
9. del Castillo F., Delgado Rubio A., Rodrigo C., de Liria G., Cervera J., Villafruela M.A., et al. [National consensus on acute otitis media (OMA)]. Ann. Pediatr. (Barc). 2007, 66:603-610.
10. Torres E., Del Castillo F. Otitis media aguda en niños. Wstudio clínico y etiólogico. Rev. Pediatr. Aten. Primaria 2000, II(6).
11. de Miguel Martinez I., Macias A.R. Serous otitis media in children: implication of Alloiococcus otitidis. Otol. Neurotol. 2008, 29:526-530.
12. Eskola J., Kilpi T., Palmu A., Jokinen J., Haapakoski J., Herva E., et al. Efficacy of a pneumococcal conjugate vaccine against acute otitis media. N. Engl. J. Med. 2001, 344:403-409.
13. Prymula R., Peeters P., Chrobok V., Kriz P., Novakova E., Kaliskova E., et al. Pneumococcal capsular polysaccharides conjugated to protein D for prevention of acute otitis media caused by both Streptococcus pneumoniae and non-typable Haemophilus influenzae: a randomised double-blind efficacy study. Lancet 2006, 367:740-748.
14. Kilpi T., Ahman H., Jokinen J., Lankinen K.S., Palmu A., Savolainen H., et al. Protective efficacy of a second pneumococcal conjugate vaccine against pneumococcal acute otitis media in infants and children: randomized, controlled trial of a 7-valent pneumococcal polysaccharide-meningococcal outer membrane protein complex conjugate vaccine in 1666 children. Clin. Infect. Dis. 2003, 37:1155-1164.
15. Fenoll Comes C., Tarragó Asensio D., Casal Lombos J. Cambios epidemiológicos en España desde la introduccion de la vaccuna neumocócica hepatvalente. Vacunas 2007, 137-149. Madrid, GlaxoSmithKline.
16. Casey J.R., Pichichero M.E. Changes in frequency and pathogens causing acute otitis media in 1995-2003. Pediatr. Infect. Dis. J. 2004, 23:824-828.
17. Pichichero M.E., Casey J.R., Hoberman A., Schwartz R. Pathogens causing recurrent and difficult-to-treat acute otitis media, 2003-2006. Clin. Pediatr. (Phila). 2008, 47:901-906.
18. Fenoll A., Aguilar L., Vicioso M.D., Gimenez M.J., Robledo O., Granizo J.J. Increase in serotype 19A prevalence and amoxicillin non-susceptibility among paediatric Streptococcus pneumoniae isolates from middle ear fluid in a passive laboratory-based surveillance in Spain, 1997-2009. BMC Infect. Dis. 2011, 11:239.
19. Murray P. Manual of Clinical Microbiology 1995, American Society of Microbiology, Washington DC. 6th ed.
20. Carvalho M., da G.S., Tondella M.L., McCaustland K., Weidlich L., McGee L., Mayer L.W., et al. Evaluation and improvement of real-time PCR assays targeting lytA, ply, and psaA genes for detection of pneumococcal DNA. J. Clin. Microbiol. 2007, 45:2460-2466.
21. Tarragó D., Fenoll A., Sánchez-Tatay D., Arroyo L.A., Muñoz-Almagro C., Esteva C., et al. Identification of pneumococcal serotypes from culture-negative clinical specimens by novel real-time PCR. Clin. Microbiol. Infect. 2008, 14:828-834.
22. Maaroufi Y., De Bruyne J.M., Heymans C., Crokaert F. Real-time PCR for determining capsular serotypes of Haemophilus influenzae. J. Clin. Microbiol. 2007, 45:2305-2308.
23. Leibovitz E., Jacobs M.R., Dagan R. Haemophilus influenzae: a significant pathogen in acute otitis media. Pediatr. Infect. Dis. J. 2004, 23:1142-1152.
24. Wiertsema S.P., Kirkham L-AS, Corscadden K.J., Mowe E.N., Bowman J.M., Jacoby P., et al. Predominance of nontypeable Haemophilus influenzae in children with otitis media following introduction of a 3+0 pneumococcal conjugate vaccine schedule. Vaccine 2011, 29:5163-5170.
25. Couloigner V., Levy C., François M., Bidet P., Hausdorff W.P., Pascal T., et al. Pathogens implicated in acute otitis media failures after 7-valent pneumococcal conjugate vaccine implementation in France: distribution, serotypes, and resistance levels. Pediatr. Infect. Dis. J. 2012, 31:154-158.
26. Xu Q., Kaur R., Casey J.R., Adlowitz D.G., Pichichero M.E., Zeng M. Identification of Streptococcus pneumoniae and Haemophilus influenzae in culture-negative middle ear fluids from children with acute otitis media by combination of multiplex PCR and multi-locus sequencing typing. Int. J. Pediatr. Otorhinolaryngol. 2011, 75:239-244.
27. Dagan R., Givon-Lavi N., Leibovitz E., Greenberg D., Porat N. Introduction and proliferation of multidrug-resistant Streptococcus pneumoniae serotype 19A clones that cause acute otitis media in an unvaccinated population. J. Infect. Dis. 2009, 199(6):776-785.
28. van Gils E.J.M., Veenhoven R.H., Hak E., Rodenburg G.D., Keijzers W.C.M., Bogaert D., et al. Pneumococcal conjugate vaccination and nasopharyngeal acquisition of pneumococcal serotype 19A strains. JAMA 2010, 304:1099-1106.
29. Dagan R., Patterson S., Juergens C., Greenberg D., Givon-Lavi N., Gurtman A., et al. Efficacy of 13-valent and 7-valent pneumococcal conjugate vaccines (PCV13;PCV7) in preventing nasopharyngeal colonization with PCV7- serotypes: a randomized double-blind trial. Abstract. 8th Pneumococci and Pneumococcal Diseases Symposium 2012, http://www2.kenes.com/ISPPD/Scientific/Documents/FinalAbstractbook.pdf.
30. Poolman J., Frasch C., Nurkka A., Käyhty H., Biemans R., Schuerman L. Impact of the conjugation method on the immunogenicity of Streptococcus pneumoniae serotype 19F polysaccharide in conjugate vaccines. Clin. Vaccine Immunol. 2011, 18(2):327-336.
31. Jokinen J., Palmu A.A., Kilpi T. Acute otitis media replacement and recurrence in the Finnish otitis media vaccine trial. Clin. Infect. Dis. 2012, 55(12):1673-1676.
32. Dupont D., Mahjoub-Messai F., François M., Doit C., Mariani-Kurkdjian P., Bidet P., et al. Evolving microbiology of complicated acute otitis media before and after introduction of the pneumococcal conjugate vaccine in France. Diagn. Microbiol. Infect. Dis. 2010, 68:89-92.
33. Hammitt L., Akech D., Morpeth S., Kihuha N., Karani A., Makumi A., et al. Reductions in nasopharyngeal carriage of Streptococcus pneumoniae and Haemophilus Influenzae 6 months after introduction of PCV10 in Kilifi, Kenya. Abstract. 8th Pneumococci and Pneumococcal Diseases Symposium 2012, http://www2.kenes.com/ISPPD/Scientific/Documents/FinalAbstractbook.pdf.
34. Van den Bergh M.R., Spijkerman J., Swinnen K.M., François N.A., Pascal T.G., Borys D., et al. Effects of the 10-valent pneumococcal nontypeable Haemophilus influenzae protein D-conjugate vaccine on nasopharyngeal bacterial colonization in young children: a randomized controlled trial. Clin. Infect. Dis. 2013, 56(3):e30-e39.
35. Borys D., Saez-Llorens X., Prymula R., Hoet B., Lommel P., Ruiz-Guinazul J., et al. Effect of 10- and 11-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccines (PHiD-CV and 11Pn-PD) on nasopharyngeal bacterial carriage. [I Abstract]. 8th Pneumococci and Pneumococcal Diseases Symposium 2012, http://www2.kenes.com/ISPPD/Scientific/Documents/FinalAbstractbook.pdf.
36. Eldan M., Leibovitz E., Piglansky L., Raiz S., Press J., Yagupsky P., et al. Predictive value of pneumococcal nasopharyngeal cultures for the assessment of nonresponsive acute otitis media in children. Pediatr. Infect. Dis. J. 2000, 19:298-303.
37. Syrjänen R.K., Herva E.E., Mäkelä P.H., Puhakka H.J., Auranen K.J., Takala A.K., et al. The value of nasopharyngeal culture in predicting the etiology of acute otitis media in children less than two years of age. Pediatr. Infect. Dis. J. 2006, 25:1032-1036.