-
1
-
-
0028865313
-
[Lys(B28), Pro(B29)]-human insulin: Effect of injection time on postprandial glycemia
-
Howey, D.C., Bowsher, R.R., Brunelle, R.L., Rowe, H.M., Santa, P.F., Downing-Shelton, J., Woodworth, J.R. [Lys(B28), Pro(B29)]-human insulin: effect of injection time on postprandial glycemia. Clin Pharmacol Ther 1995, 58(4): 459-69.
-
(1995)
Clin Pharmacol Ther
, vol.58
, Issue.4
, pp. 459-469
-
-
Howey, D.C.1
Bowsher, R.R.2
Brunelle, R.L.3
Rowe, H.M.4
Santa, P.F.5
Downing-Shelton, J.6
Woodworth, J.R.7
-
2
-
-
0032841674
-
Insulin aspart (B28 Asp-insulin): A fast-acting analog of human insulin: Absorption kinetics and action profile compared with regular human insulin in healthy nondiabetic subjects
-
DOI 10.2337/diacare.22.9.1501
-
Mudaliar, S.R., Lindberg, F.A., Joyce, M., Beerdsen, P., Strange, P., Lin, A., Henry, R.R. Insulin aspart (B28 asp-insulin): a fast-acting analog of human insulin: absorption kinetics and action profile compared with regular human insulin in healthy nondiabetic subjects. Diabetes Care 1999, 22(9): 1501-6. (Pubitemid 29418246)
-
(1999)
Diabetes Care
, vol.22
, Issue.9
, pp. 1501-1506
-
-
Mudaliar, S.R.1
Lindberg, F.A.2
Joyce, M.3
Beerdsen, P.4
Strange, P.5
Lin, A.6
Henry, R.R.7
-
3
-
-
24144461899
-
Pharmacokinetics, prandial glucose control, and safety of insulin glulisine in children and adolescents with type 1 diabetes
-
DOI 10.2337/diacare.28.9.2100
-
Danne, T., Becker, R.H., Heise, T., Bittner, C., Frick, A.D., Rave, K. Pharmacokinetics, prandial glucose control, and safety of insulin glulisine in children and adolescents with type 1 diabetes. Diabetes Care 2005, 28(9): 2100-5. (Pubitemid 41242451)
-
(2005)
Diabetes Care
, vol.28
, Issue.9
, pp. 2100-2105
-
-
Danne, T.1
Becker, R.H.A.2
Heise, T.3
Bittner, C.4
Frick, A.D.5
Rave, K.6
-
4
-
-
25444468590
-
Insulin glulisine, a new rapid-acting insulin analogue, displays a rapid time-action profile in obese non-diabetic subjects
-
DOI 10.1055/s-2005-865806
-
Becker, R.H., Frick, A.D., Burger, F., Potgieter, J.H., Scholtz, H. Insulin glulisine, a new rapid-acting insulin analogue, displays a rapid time-action profile in obese non-diabetic subjects. Exp Clin Endocrinol Diabetes 2005, 113(8): 435-43. (Pubitemid 41360749)
-
(2005)
Experimental and Clinical Endocrinology and Diabetes
, vol.113
, Issue.8
, pp. 435-443
-
-
Becker, R.H.A.1
Frick, A.D.2
Burger, F.3
Potgieter, J.H.4
Scholtz, H.5
-
5
-
-
0000360859
-
Protamine insulin
-
Hagedorn, H.C., Jensen, B.N., Krarup, N.B., Woodstrup, I. Protamine insulin. JAMA 1936, 106: 177-80.
-
(1936)
JAMA
, vol.106
, pp. 177-180
-
-
Hagedorn, H.C.1
Jensen, B.N.2
Krarup, N.B.3
Woodstrup, I.4
-
7
-
-
0000588546
-
Crystalline amorphous insulin-zinc compounds with prolonged action
-
Hallas-Moller, K., Peterson, K., Schlitchkrull, J. Crystalline amorphous insulin-zinc compounds with prolonged action. Science 1952, 116(3105): 394-98.
-
(1952)
Science
, vol.116
, Issue.3105
, pp. 394-398
-
-
Hallas-Moller, K.1
Peterson, K.2
Schlitchkrull, J.3
-
8
-
-
4243744696
-
The lente insulins, insulin-zinc suspensions
-
Hallas-Moller, K., Jersild, M., Peterson, K., Schlitchkrull, J. The lente insulins, insulin-zinc suspensions. Dan Med Bull 1954, 1(5): 132-42.
-
(1954)
Dan Med Bull
, vol.1
, Issue.5
, pp. 132-142
-
-
Hallas-Moller, K.1
Jersild, M.2
Peterson, K.3
Schlitchkrull, J.4
-
9
-
-
0023225028
-
Miscibility of human semisynthetic regular and lente insulin and human biosynthetic regular and NPH insulin
-
Olsson, P.O., Hans, A., Henning, V.S. Miscibility of human semisynthetic regular and lente insulin and human biosynthetic regular and NPH insulin. Diabetes Care 1987, 10(4): 473-7.
-
(1987)
Diabetes Care
, vol.10
, Issue.4
, pp. 473-477
-
-
Olsson, P.O.1
Hans, A.2
Henning, V.S.3
-
10
-
-
0034609223
-
Insulin glargine
-
Bolli, G.B., Owens, D.R. Insulin glargine. Lancet 2000, 356(9228): 443-5. (Pubitemid 30496809)
-
(2000)
Lancet
, vol.356
, Issue.9228
, pp. 443-445
-
-
Bolli, G.B.1
Owens, D.R.2
-
11
-
-
0034203532
-
125I-labeled insulin glargine (HOE 901) in healthy men: Comparison with NPH insulin and the influence of different subcutaneous injection sites
-
Owens, D.R., Coates, P.A., Luzio, S.D., Tinbergen, J.P., Kurzhals, R. Pharmacokinetics of 125I-labeled insulin glargine (HOE 901) in healthy men: comparison with NPH insulin and the influence of different subcutaneous injection sites. Diabetes Care 2000, 23(6): 813-9. (Pubitemid 30414199)
-
(2000)
Diabetes Care
, vol.23
, Issue.6
, pp. 813-819
-
-
Owens, D.R.1
Coates, P.A.2
Luzio, S.D.3
Tinbergen, J.P.4
Kurzhals, R.5
-
12
-
-
0033661254
-
Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro
-
Lepore, M., Pampanelli, S., Fanelli, C. et al. Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro. Diabetes 2000, 49(12): 2142-8.
-
(2000)
Diabetes
, vol.49
, Issue.12
, pp. 2142-2148
-
-
Lepore, M.1
Pampanelli, S.2
Fanelli, C.3
-
13
-
-
26244459804
-
Pharmacokinetic and glucodynamic variability: Assessment of insulin glargine, NPH insulin and insulin ultralente in healthy volunteers using a euglycaemic clamp technique
-
DOI 10.1007/s00125-005-1916-y
-
Scholtz, H.E., Pretorius, S.G., Wessels, D.H., Becker, R.H. Pharmacokinetic and glucodynamic variability: assessment of insulin glargine, NPH insulin and insulin ultralente in healthy volunteers using a euglycaemic clamp technique. Diabetologia 2005, 48(10): 1988-95. (Pubitemid 41416907)
-
(2005)
Diabetologia
, vol.48
, Issue.10
, pp. 1988-1995
-
-
Scholtz, H.E.1
Pretorius, S.G.2
Wessels, D.H.3
Becker, R.H.A.4
-
14
-
-
24744442762
-
Glargine is superior to neutral protamine Hagedorn for improving glycated haemoglobin and fasting blood glucose levels during intensive insulin therapy
-
DOI 10.1111/j.1445-5994.2005.00902.x
-
Fulcher, G.R., Gilbert, R.E., Yue, D.K. Glargine is superior to neutral protamine Hagedorn for improving glycated haemoglobin and fasting blood glucose levels during intensive insulin therapy. Intern Med J 2005, 35(9): 536-42. (Pubitemid 41291382)
-
(2005)
Internal Medicine Journal
, vol.35
, Issue.9
, pp. 536-542
-
-
Fulcher, G.R.1
Gilbert, R.E.2
Yue, D.K.3
-
15
-
-
34249869514
-
Glycaemic control and hypoglycaemia in children, adolescents and young adults with unstable type 1 diabetes mellitus treated with insulin glargine or intermediate-acting insulin
-
Herwig, J., Scholl-Schilling, G., Bohles, H. Glycaemic control and hypoglycaemia in children, adolescents and young adults with unstable type 1 diabetes mellitus treated with insulin glargine or intermediate-acting insulin. J Pediatr Endocrinol Metab 2007, 20(4): 517-25. (Pubitemid 46865032)
-
(2007)
Journal of Pediatric Endocrinology and Metabolism
, vol.20
, Issue.4
, pp. 517-525
-
-
Herwig, J.1
Scholl-Schilling, G.2
Bohles, H.3
-
16
-
-
0038248890
-
Intensive replacement of basal insulin in patients with type 1 diabetes given rapid-acting insulin analog at mealtime: A 3-month comparison between administration of NPH insulin four times daily and glargine insulin at dinner or bedtime
-
DOI 10.2337/diacare.26.5.1490
-
Rossetti, P., Pampanelli, S., Fanelli, C. et al. Intensive replacement of basal insulin in patients with type 1 diabetes given rapid-acting insulin analog at mealtime: a 3-month comparison between administration of NPH insulin four times daily and glargine insulin at dinner or bedtime. Diabetes Care 2003, 26(5): 1490-6. (Pubitemid 36929184)
-
(2003)
Diabetes Care
, vol.26
, Issue.5
, pp. 1490-1496
-
-
Rossetti, P.1
Pampanelli, S.2
Fanelli, C.3
Porcellati, F.4
Costa, E.5
Torlone, E.6
Scionti, L.7
Bolli, G.B.8
-
17
-
-
0034827469
-
Basal insulin therapy in type 2 diabetes: 28-Week comparison of insulin glargine (HOE 901) and NPH insulin
-
Rosenstock, J., Schwartz, S.L., Clark, C.M., Jr., Park, G.D., Donley, D.W., Edwards, M.B. Basal insulin therapy in type 2 diabetes: 28-week comparison of insulin glargine (HOE 901) and NPH insulin. Diabetes Care 2001, 24(4): 631-6. (Pubitemid 32888839)
-
(2001)
Diabetes Care
, vol.24
, Issue.4
, pp. 631-636
-
-
Rosenstock, J.1
Schwartz, S.L.2
Clark Jr., C.M.3
Park, G.D.4
Donley, D.W.5
Edwards, M.B.6
-
18
-
-
15944382350
-
Reduced hypoglycemia risk with insulin glargine: A meta-analysis comparing insulin glargine with human NPH insulin in type 2 diabetes
-
DOI 10.2337/diacare.28.4.950
-
Rosenstock, J., Dailey, G., Massi-Benedetti, M., Fritsche, A., Lin, Z., Salzman, A. Reduced hypoglycemia risk with insulin glargine: a meta-analysis comparing insulin glargine with human NPH insulin in type 2 diabetes. Diabetes Care 2005, 28(4): 950-5. (Pubitemid 40434505)
-
(2005)
Diabetes Care
, vol.28
, Issue.4
, pp. 950-955
-
-
Rosenstock, J.1
Dailey, G.2
Massi-Benedetti, M.3
Fritsche, A.4
Lin, Z.5
Salzman, A.6
-
19
-
-
4344701890
-
The mechanism of protraction of insulin detemir, a long-acting, acylated analog of human insulin
-
DOI 10.1023/B:PHAM.0000036926.54824.37
-
Havelund, S., Plum, A., Ribel, U., Jonassen, I., Volund, A., Markussen, J., Kurtzhals, P. The mechanism of protraction of insulin detemir, a long-acting, acylated analog of human insulin. Pharm Res 2004, 21(8): 1498-504. (Pubitemid 39149667)
-
(2004)
Pharmaceutical Research
, vol.21
, Issue.8
, pp. 1498-1504
-
-
Havelund, S.1
Plum, A.2
Ribel, U.3
Jonassen, I.4
Volund, A.5
Markussen, J.6
Kurtzhals, P.7
-
20
-
-
20944432717
-
A double-blind, randomized, dose-response study investigating the pharmacodynamic and pharmacokinetic properties of the long-acting insulin analog detemir
-
DOI 10.2337/diacare.28.5.1107
-
Plank, J., Bodenlenz, M., Sinner, F. et al. A double-blind, randomized, dose-response study investigating the pharmacodynamic and pharmacokinetic properties of the long-acting insulin analog detemir. Diabetes Care 2005, 28(5): 1107-12. (Pubitemid 40616620)
-
(2005)
Diabetes Care
, vol.28
, Issue.5
, pp. 1107-1112
-
-
Plank, J.1
Bodenlenz, M.2
Sinner, F.3
Magnes, C.4
Gorzer, E.5
Regittnig, W.6
Endahl, L.A.7
Draeger, E.8
Zdravkovic, M.9
Pieber, T.R.10
-
21
-
-
35148873099
-
Comparison of pharmacokinetics and dynamics of the long-acting insulin analogs glargine and detemir at steady state in type 1 diabetes: A double-blind, randomized, crossover study
-
DOI 10.2337/dc07-0002
-
Porcellati, F., Rossetti, P., Busciantella, N.R. et al. Comparison of pharmacokinetics and dynamics of the long-acting insulin analogs glargine and detemir at steady state in type 1 diabetes: a double-blind, randomized, crossover study. Diabetes Care 2007, 30(10): 2447-52. (Pubitemid 47547770)
-
(2007)
Diabetes Care
, vol.30
, Issue.10
, pp. 2447-2452
-
-
Porcellati, F.1
Rossetti, P.2
Busciantella, N.R.3
Marzotti, S.4
Lucidi, P.5
Luzio, S.6
Owens, D.R.7
Bolli, G.B.8
Fanelli, C.G.9
-
22
-
-
33748555885
-
Insulin detemir lowers the risk of hypoglycaemia and provides more consistent plasma glucose levels compared with NPH insulin in Type 1 diabetes
-
DOI 10.1111/j.1464-5491.2006.01862.x
-
Kolendorf, K., Ross, G.P., Pavlic-Renar, I. et al. Insulin detemir lowers the risk of hypoglycaemia and provides more consistent plasma glucose levels compared with NPH insulin in Type 1 diabetes. Diabet Med 2006, 23(7): 729-35. (Pubitemid 44366070)
-
(2006)
Diabetic Medicine
, vol.23
, Issue.7
, pp. 729-735
-
-
Kolendorf, K.1
Ross, G.P.2
Pavlic-Renar, I.3
Perriello, G.4
Philotheou, A.5
Jendle, J.6
Gall, M.-A.7
Heller, S.R.8
-
23
-
-
33746910579
-
Time-action profile of insulin detemir and NPH insulin in patients with type 2 diabetes from different ethnic groups
-
DOI 10.1111/j.1463-1326.2006.00643.x
-
Hompesch, M., Troupin, B., Heise, T., Elbroend, B., Endahl, L., Haahr, H., Heinemann, L. Time-action profile of insulin detemir and NPH insulin in patients with type 2 diabetes from different ethnic groups. Diabetes Obes Metab 2006, 8(5): 568-73. (Pubitemid 44184251)
-
(2006)
Diabetes, Obesity and Metabolism
, vol.8
, Issue.5
, pp. 568-573
-
-
Hompesch, M.1
Troupin, B.2
Heise, T.3
Elbroend, B.4
Endahl, L.5
Haahr, H.6
Heinemann, L.7
-
24
-
-
84864460325
-
Design of the novel protraction mechanism of insulin degludec, an ultra-long-acting basal insulin
-
Jonassen, I., Havelund, S., Hoeg-Jensen, T., Steensgaard, D.B., Wahlund, P.O., Ribel, U. Design of the novel protraction mechanism of insulin degludec, an ultra-long-acting basal insulin. Pharm Res 2012, 29(8): 2104-14.
-
(2012)
Pharm Res
, vol.29
, Issue.8
, pp. 2104-2114
-
-
Jonassen, I.1
Havelund, S.2
Hoeg-Jensen, T.3
Steensgaard, D.B.4
Wahlund, P.O.5
Ribel, U.6
-
25
-
-
84872522953
-
Ligand-controlled assembly of hexamers, dihexamers, and linear multihexamer structures by the engineered acylated insulin degludec
-
Steensgaard, D.B., Schluckebier, G., Strauss, H.M. et al. Ligand-controlled assembly of hexamers, dihexamers, and linear multihexamer structures by the engineered acylated insulin degludec. Biochemistry 2013, 52(2): 295-309.
-
(2013)
Biochemistry
, vol.52
, Issue.2
, pp. 295-309
-
-
Steensgaard, D.B.1
Schluckebier, G.2
Strauss, H.M.3
-
26
-
-
79952484368
-
Insulin degludec is a new generation ultra-long acting basal insulin with a unique mechanism of protraction based on multi-hexamer formation
-
[70th Annu Meet Sci Sess Am Diabetes Assoc (ADA) (June 25-29, Orlando) 2010] Abst 39-OR
-
Jonassen, I.B., Havelund, S., Ribel, U., et al. Insulin degludec is a new generation ultra-long acting basal insulin with a unique mechanism of protraction based on multi-hexamer formation. Diabetes [70th Annu Meet Sci Sess Am Diabetes Assoc (ADA) (June 25-29, Orlando) 2010] 2010, 59(Suppl. 1): Abst 39-OR.
-
(2010)
Diabetes
, vol.59
, Issue.SUPPL. 1
-
-
Jonassen, I.B.1
Havelund, S.2
Ribel, U.3
-
27
-
-
84880013714
-
Insulin degludec has a two-fold longer half-life and a more consistent pharmacokinetic profile than insulin glargine
-
Abst 0037-LB
-
Heise, T., Nosek, L., Nosek, L., Bottcher, S.G., Granhall, C., Haahr, H. Insulin degludec has a two-fold longer half-life and a more consistent pharmacokinetic profile than insulin glargine. 71st Annu Meet Sci Sess Am Diabetes Assoc (ADA) (June 24-28, San Diego) 2011, Abst 0037-LB.
-
71st Annu Meet Sci Sess Am Diabetes Assoc (ADA) (June 24-28, San Diego) 2011
-
-
Heise, T.1
Nosek, L.2
Nosek, L.3
Bottcher, S.G.4
Granhall, C.5
Haahr, H.6
-
28
-
-
84872310771
-
The pharmacokinetic properties of insulin degludec in children and adolescents compared with adults with type 1 diabetes after single-dose administration
-
37th Ann Meet Int Soc Pediatric Adolescent Diabetes (ISPAD) (Oct 19-22, Miami Beach) 2011
-
Danne, T., Biester, T., Blaesig, S., et al. The pharmacokinetic properties of insulin degludec in children and adolescents compared with adults with type 1 diabetes after single-dose administration. Pediatric Diabetes [37th Ann Meet Int Soc Pediatric Adolescent Diabetes (ISPAD) (Oct 19-22, Miami Beach) 2011] 2011, 12(Suppl. 15): 35-6.
-
(2011)
Pediatric Diabetes
, vol.12
, Issue.SUPPL. 15
, pp. 35-36
-
-
Danne, T.1
Biester, T.2
Blaesig, S.3
-
29
-
-
79956118439
-
Insulin degludec: Less pharmacodynamic variability than insulin glargine under steady state conditions
-
[46th Annu Meet Eur Assoc Study Diabetes (EASD) (Sept 20-24, Stockholm) 2010] Abst 971
-
Heise, T., Hermanski, L., Nosek, L., Feldmann, A., Rasmussen, S., Stryhn, T.K., Haahr, H. Insulin degludec: Less pharmacodynamic variability than insulin glargine under steady state conditions. Diabetologia [46th Annu Meet Eur Assoc Study Diabetes (EASD) (Sept 20-24, Stockholm) 2010] 2010, 53(Suppl. 1): Abst 971.
-
(2010)
Diabetologia
, vol.53
, Issue.SUPPL. 1
-
-
Heise, T.1
Hermanski, L.2
Nosek, L.3
Feldmann, A.4
Rasmussen, S.5
Stryhn, T.K.6
Haahr, H.7
-
30
-
-
84880022706
-
The pharmacodynamic variability of insulin degludec is consistently lower than insulin glargine over 24 hours at steady state
-
Abst 0960-P
-
Heise, T., Hermanski, L., Nosek, L.F., A.;, Rasmussen, S., Haahr, H. The pharmacodynamic variability of insulin degludec is consistently lower than insulin glargine over 24 hours at steady state. 71st Annu Meet Sci Sess Am Diabetes Assoc (ADA) (June 24-28, San Diego) 2011, Abst 0960-P.
-
71st Annu Meet Sci Sess Am Diabetes Assoc (ADA) (June 24-28, San Diego) 2011
-
-
Heise, T.1
Hermanski, L.2
Nosek, L.F.A.3
Rasmussen, S.4
Haahr, H.5
-
31
-
-
79956152438
-
Ultra-long acting insulin degludec can be combined with rapid-acting insulin aspart in a soluble co-formulation
-
Jonassen, I., Hoeg-Jensen, T., Havelund, S., Ribel, U. Ultra-long acting insulin degludec can be combined with rapid-acting insulin aspart in a soluble co-formulation. J Pept Sci 2010, 16(Suppl. 1): 32.
-
(2010)
J Pept Sci
, vol.16
, Issue.SUPPL. 1
, pp. 32
-
-
Jonassen, I.1
Hoeg-Jensen, T.2
Havelund, S.3
Ribel, U.4
-
32
-
-
84880013198
-
IDegAsp, a soluble insulin combination of ultra-long-acting insulin degludec and insulin aspart, in type 2 diabetes: Comparison with biphasic insulin aspart 30
-
Abst 1040
-
Vaag, A., Leiter, L.A., Franek, E., et al. IDegAsp, a soluble insulin combination of ultra-long-acting insulin degludec and insulin aspart, in type 2 diabetes: Comparison with biphasic insulin aspart 30. 47th Annu Meet Eur Assoc Study Diabetes (EASD) (Sept 12-16, Lisbon) 2011, Abst 1040.
-
47th Annu Meet Eur Assoc Study Diabetes (EASD) (Sept 12-16, Lisbon) 2011
-
-
Vaag, A.1
Leiter, L.A.2
Franek, E.3
-
33
-
-
84864375931
-
Insulin degludec: Four times lower pharmacodynamic variability than insulin glargine under steady-state conditions in type 1 diabetes
-
Heise, T., Hermanski, L., Nosek, L., Feldman, A., Rasmussen, S., Haahr, H. Insulin degludec: four times lower pharmacodynamic variability than insulin glargine under steady-state conditions in type 1 diabetes. Diabetes Obes Metab 2012, 14(9): 859-64.
-
(2012)
Diabetes Obes Metab
, vol.14
, Issue.9
, pp. 859-864
-
-
Heise, T.1
Hermanski, L.2
Nosek, L.3
Feldman, A.4
Rasmussen, S.5
Haahr, H.6
-
34
-
-
79952488537
-
Insulin degludec, an ultra-long-acting basal insulin, once a day or three times a week versus insulin glargine once a day in patients with type 2 diabetes: A 16-week, randomised, open-label, phase 2 trial
-
Zinman, B., Fulcher, G., Rao, P.V. et al. Insulin degludec, an ultra-long-acting basal insulin, once a day or three times a week versus insulin glargine once a day in patients with type 2 diabetes: a 16-week, randomised, open-label, phase 2 trial. Lancet 2011, 377(9769): 924-31.
-
(2011)
Lancet
, vol.377
, Issue.9769
, pp. 924-931
-
-
Zinman, B.1
Fulcher, G.2
Rao, P.V.3
-
38
-
-
84869842163
-
Insulin degludec versus insulin glargine in insulin-naive patients with type 2 diabetes: A 1-year, randomized, treat-to-target trial (BEGIN Once Long)
-
Zinman, B., Philis-Tsimikas, A., Cariou, B. et al. Insulin degludec versus insulin glargine in insulin-naive patients with type 2 diabetes: a 1-year, randomized, treat-to-target trial (BEGIN Once Long). Diabetes Care 2012, 35(12): 2464-71.
-
(2012)
Diabetes Care
, vol.35
, Issue.12
, pp. 2464-2471
-
-
Zinman, B.1
Philis-Tsimikas, A.2
Cariou, B.3
-
39
-
-
84859921058
-
Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 2 diabetes (BEGIN Basal-Bolus Type 2): A phase 3, randomised, open-label, treat-to-target non-inferiority trial
-
Garber, A.J., King, A.B., Del Prato, S. et al. Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 2 diabetes (BEGIN Basal-Bolus Type 2): a phase 3, randomised, open-label, treat-to-target non-inferiority trial. Lancet 2012, 379(9825): 1498-507.
-
(2012)
Lancet
, vol.379
, Issue.9825
, pp. 1498-1507
-
-
Garber, A.J.1
King, A.B.2
Del Prato, S.3
-
40
-
-
84859896417
-
Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basalbolus treatment with mealtime insulin aspart in type 1 diabetes (BEGIN Basal-Bolus Type 1): A phase 3, randomised, open-label, treat-to-target non-inferiority trial
-
Heller, S., Buse, J., Fisher, M. et al. Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basalbolus treatment with mealtime insulin aspart in type 1 diabetes (BEGIN Basal-Bolus Type 1): a phase 3, randomised, open-label, treat-to-target non-inferiority trial. Lancet 2012, 379(9825): 1489-97.
-
(2012)
Lancet
, vol.379
, Issue.9825
, pp. 1489-1497
-
-
Heller, S.1
Buse, J.2
Fisher, M.3
-
41
-
-
84874858316
-
Efficacy and safety of insulin degludec in a flexible dosing regimen vs insulin glargine in patients with type 1 diabetes (BEGIN: Flex T1): A 26-week randomized, treat-to-target trial with a 26-week extension
-
Mathieu, C., Hollander, P., Miranda-Palma, B. et al. Efficacy and safety of insulin degludec in a flexible dosing regimen vs insulin glargine in patients with type 1 diabetes (BEGIN: Flex T1): a 26-week randomized, treat-to-target trial with a 26-week extension. J Clin Endocrinol Metab 2013, 98(3): 1154-62.
-
(2013)
J Clin Endocrinol Metab
, vol.98
, Issue.3
, pp. 1154-1162
-
-
Mathieu, C.1
Hollander, P.2
Miranda-Palma, B.3
-
42
-
-
84875444482
-
The efficacy and safety of insulin degludec given in variable once-daily dosing intervals compared with insulin glargine and insulin degludec dosed at the same time daily: A 26-week, randomized, open-label, parallel-group, treat-to-target trial in individuals with type 2 diabetes
-
Meneghini, L., Atkin, S.L., Gough, S.C. et al. The efficacy and safety of insulin degludec given in variable once-daily dosing intervals compared with insulin glargine and insulin degludec dosed at the same time daily: a 26-week, randomized, open-label, parallel-group, treat-to-target trial in individuals with type 2 diabetes. Diabetes Care 2013, 36(4): 858-64.
-
(2013)
Diabetes Care
, vol.36
, Issue.4
, pp. 858-864
-
-
Meneghini, L.1
Atkin, S.L.2
Gough, S.C.3
-
43
-
-
84871937855
-
Hypoglycaemia risk with insulin degludec compared with insulin glargine in type 2 and type 1 diabetes: A pre-planned meta-analysis of phase 3 trials
-
Ratner, R.E., Gough, S.C., Mathieu, C. et al. Hypoglycaemia risk with insulin degludec compared with insulin glargine in type 2 and type 1 diabetes: a pre-planned meta-analysis of phase 3 trials. Diabetes Obes Metab 2013, 15(2): 175-84.
-
(2013)
Diabetes Obes Metab
, vol.15
, Issue.2
, pp. 175-184
-
-
Ratner, R.E.1
Gough, S.C.2
Mathieu, C.3
-
44
-
-
84868133240
-
Insulin degludec/insulin aspart administered once daily at any meal, with insulin aspart at other meals versus a standard basal-bolus regimen in patients with type 1 diabetes: A 26-week, phase 3, randomized, open-label, treat-to-target trial
-
Hirsch, I.B., Bode, B., Courreges, J.P. et al. Insulin degludec/insulin aspart administered once daily at any meal, with insulin aspart at other meals versus a standard basal-bolus regimen in patients with type 1 diabetes: a 26-week, phase 3, randomized, open-label, treat-to-target trial. Diabetes Care 2012, 35(11): 2174-81.
-
(2012)
Diabetes Care
, vol.35
, Issue.11
, pp. 2174-2181
-
-
Hirsch, I.B.1
Bode, B.2
Courreges, J.P.3
-
45
-
-
74949117631
-
The association between symptomatic, severe hypoglycaemia and mortality in type 2 diabetes: Retrospective epidemiological analysis of the ACCORD study
-
Bonds, D.E., Miller, M.E., Bergenstal, R.M. et al. The association between symptomatic, severe hypoglycaemia and mortality in type 2 diabetes: retrospective epidemiological analysis of the ACCORD study. BMJ 2010, 340: b4909.
-
(2010)
BMJ
, vol.340
-
-
Bonds, D.E.1
Miller, M.E.2
Bergenstal, R.M.3
-
46
-
-
82755165018
-
Intensive glycaemic control for patients with type 2 diabetes: Systematic review with meta-analysis and trial sequential analysis of randomised clinical trials
-
Hemmingsen, B., Lund, S.S., Gluud, C., Vaag, A., Almdal, T., Hemmingsen, C., Wetterslev, J. Intensive glycaemic control for patients with type 2 diabetes: systematic review with meta-analysis and trial sequential analysis of randomised clinical trials. BMJ 2011, 343: d6898.
-
(2011)
BMJ
, vol.343
-
-
Hemmingsen, B.1
Lund, S.S.2
Gluud, C.3
Vaag, A.4
Almdal, T.5
Hemmingsen, C.6
Wetterslev, J.7
-
47
-
-
70349881450
-
Intensive glucose control and macrovascular outcomes in type 2 diabetes
-
Turnbull, F.M., Abraira, C., Anderson, R.J. et al. Intensive glucose control and macrovascular outcomes in type 2 diabetes. Diabetologia 2009, 52(11): 2288-98.
-
(2009)
Diabetologia
, vol.52
, Issue.11
, pp. 2288-2298
-
-
Turnbull, F.M.1
Abraira, C.2
Anderson, R.J.3
-
50
-
-
84874126220
-
The path to approval of new drugs for diabetes
-
Rendell, M. The path to approval of new drugs for diabetes. Expert Opin Drug Saf 2013, 12(2): 195-207.
-
(2013)
Expert Opin Drug Saf
, vol.12
, Issue.2
, pp. 195-207
-
-
Rendell, M.1
-
51
-
-
6944245418
-
Preserved circadian rhythm of serum insulin concentration at low plasma glucose during fasting in lean and overweight humans
-
DOI 10.1016/j.metabol.2004.06.012, PII S0026049504002677
-
Merl, V., Peters, A., Oltmanns, K.M. et al. Preserved circadian rhythm of serum insulin concentration at low plasma glucose during fasting in lean and overweight humans. Metabolism 2004, 53(11): 1449-53. (Pubitemid 39410385)
-
(2004)
Metabolism: Clinical and Experimental
, vol.53
, Issue.11
, pp. 1449-1453
-
-
Merl, V.1
Peters, A.2
Oltmanns, K.M.3
Kern, W.4
Hubold, C.5
Hallschmid, M.6
Born, J.7
Fehm, H.L.8
Schultes, B.9
-
52
-
-
84874161645
-
Glargine safety, diabetes and cancer
-
Rendell, M., Akturk, H.K., Tella, S.H. Glargine safety, diabetes and cancer. Expert Opin Drug Saf 2013, 12(2): 247-63.
-
(2013)
Expert Opin Drug Saf
, vol.12
, Issue.2
, pp. 247-263
-
-
Rendell, M.1
Akturk, H.K.2
Tella, S.H.3
|