Blood Neutrophil Counts in HIV-Infected Patients with Pulmonary Tuberculosis: Association with Sputum Mycobacterial Load

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Kerkhoff, Andrew D ^a,b   Wood, Robin ^b   Lowe, David M ^b,c   Vogt, Monica ^b   Lawn, Stephen D ^b,d  

^a GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT;

ADULT; ANTIVIRAL THERAPY; ARTICLE; BACTERIAL LOAD; CD4 LYMPHOCYTE COUNT; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LIQUID CULTURE; LUNG TUBERCULOSIS; MAJOR CLINICAL STUDY; MALE; MYCOBACTERIUM; NEUTROPHIL COUNT; NEUTROPHILIA; NONHUMAN; REFERENCE VALUE; SCREENING TEST; SPUTUM MYCOBACTERIA LOAD; SPUTUM SMEAR;

ADULT; COINFECTION; FEMALE; HIV INFECTIONS; HUMANS; LEUKOCYTE COUNT; MALE; NEUTROPHILS; RISK FACTORS; SOUTH AFRICA; SPUTUM; TUBERCULOSIS, PULMONARY;

MYCOBACTERIUM TUBERCULOSIS;

EID: 84879988106     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067956     Document Type: Article

References (27)

1. Lowe DM, Redford PS, Wilkinson RJ, O'Garra A, Martineau AR, (2012) Neutrophils in tuberculosis: friend or foe? Trends in Immunology 33: 14-25 doi:10.1016/j.it.2011.10.003.
2. Eum S-Y, (2010) Neutrophils Are the Predominant Infected Phagocytic Cells in the Airways of Patients With Active Pulmonary TB. Chest 137: 122 doi:10.1378/chest.09-0903.
3. Martineau AR, Newton SM, Wilkinson KA, Kampmann B, Hall BM, et al. (2007) Neutrophil-mediated innate immune resistance to mycobacteria. J Clin Invest 117: 1988-1994 doi:10.1172/JCI31097.
4. Lawn SD, Zumla AI, (2011) Tuberculosis. Lancet 378: 57-72 doi:10.1016/S0140-6736(10)62173-3.
5. Martineau AR, Timms PM, Bothamley GH, Hanifa Y, Islam K, et al. (2011) High-dose vitamin D3 during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial. The Lancet 377: 242-250 doi:10.1016/S0140-6736(10)61889-2.
6. Barnes PF, Leedom JM, Chan LS, Wong SF, Shah J, et al. (1988) Predictors of short-term prognosis in patients with pulmonary tuberculosis. J INFECT DIS 158: 366-371.
7. Bandara A, Bremmer S, Barker RD, Packe G, Griffiths C, et al. (2008) Neutrophilia in Tuberculosis [abstract]. Thorax 63suppl 7: A114.
8. Lawn SD, Kerkhoff AD, Vogt M, Ghebrekristos Y, Whitelaw A, et al. (2012) Characteristics and Early Outcomes of Patients With Xpert MTB/RIF-Negative Pulmonary Tuberculosis Diagnosed During Screening Before Antiretroviral Therapy. CLIN INFECT DIS 54: 1071-1079 doi:10.1093/cid/cir1039.
9. Lawn SD, Kerkhoff AD, Vogt M, Wood R (2012) High diagnostic yield of tuberculosis from screening urine samples from HIV-infected patients with advanced immunodeficiency using the Xpert MTB/RIF assay. J Acquir Immune Defic Syndr. doi:10.1097/QAI.0b013e318258c6af.
10. Lawn SD, Kerkhoff AD, Vogt M, Wood R, (2012) Clinical significance of lipoarabinomannan detection in urine using a low-cost point-of-care diagnostic assay for HIV-associated tuberculosis. AIDS 26: 1635-1643 doi:10.1097/QAD.0b013e3283553685.
11. Lawn SD, Kerkhoff AD, Vogt M, Wood RR, (2013) Diagnostic and prognostic value of serum C-reactive protein for screening for HIV-associated tuberculosis. Int J Tuberc Lung Dis 17: 636-643 doi:10.5588/ijtld.12.0811.
12. Lawn SD, Myer L, Bekker L-G, Wood R, (2006) Burden of tuberculosis in an antiretroviral treatment programme in sub-Saharan Africa: impact on treatment outcomes and implications for tuberculosis control. AIDS 20: 1605-1612 doi:10.1097/01.aids.0000238406.93249.cd.
13. Lawn SD, Myer L, Orrell C, Bekker L-G, Wood R, (2005) Early mortality among adults accessing a community-based antiretroviral service in South Africa: implications for programme design. AIDS 19: 2141-2148.
14. Lawn SD, Myer L, Bekker L-G, Wood R, (2007) Tuberculosis-associated immune reconstitution disease: incidence, risk factors and impact in an antiretroviral treatment service in South Africa. AIDS 21: 335-341 doi:10.1097/QAD.0b013e328011efac.
15. Gupta A, Wood R, Kaplan R, Bekker L-G, Lawn SD, (2013) Prevalent and Incident Tuberculosis Are Independent Risk Factors for Mortality among Patients Accessing Antiretroviral Therapy in South Africa. PLoS ONE 8: e55824 doi:10.1371/journal.pone.0055824.t003.
16. Getahun H, Kittikraisak W, Heilig CM, Corbett EL, Ayles H, et al. (2011) Development of a standardized screening rule for tuberculosis in people living with HIV in resource-constrained settings: individual participant data meta-analysis of observational studies. PLoS Med 8: e1000391 doi:10.1371/journal.pmed.1000391.
17. Lawn SD, Kerkhoff AD, Pahlana P, Vogt M, Wood RR (2012) Diagnostic yield of tuberculosis using sputum induction in HIV-positive patients before antiretroviral therapy. Int J Tuberc Lung Dis. doi:10.5588/ijtld.12.0174.
18. Lawn SD, Mwaba P, Bates M, Piatek A, Alexander H, et al. (2013) Advances in tuberculosis diagnostics: the Xpert MTB/RIF assay and future prospects for a point-of-care test. Lancet Infect Dis: 1-13. doi:10.1016/S1473-3099(13)70008-2.
19. Ashitani JI, (2002) Elevated Levels of α-Defensins in Plasma and BAL Fluid of Patients With Active Pulmonary Tuberculosis. Chest 121: 519-526 doi:10.1378/chest.121.2.519.
20. Condos R, Rom WN, Liu YM, Schluger NW, (1998) Local immune responses correlate with presentation and outcome in tuberculosis. Am J Respir Crit Care Med 157: 729-735.
21. Nandi B, Behar SM, (2011) Regulation of neutrophils by interferon- limits lung inflammation during tuberculosis infection. Journal of Experimental Medicine 208: 2251-2262 doi:10.1084/jem.20110919.
22. Anbarasu D, Ponnu Raja C, Raja A (2013) Multiplex analysis of cytokines/chemokines as biomarkers that differentiate healthy contacts from tuberculosis patients in high endemic settings. Cytokine. doi:10.1016/j.cyto.2012.12.031.
23. Furze RC, Rankin SM, (2008) Neutrophil mobilization and clearance in the bone marrow. Immunology 125: 281-288 doi:10.1111/j.1365-2567.2008.02950.x.
24. Liu F, Poursine-Laurent J, Wu HY, Link DC, (1997) Interleukin-6 and the granulocyte colony-stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation. Blood 90: 2583-2590.
25. Shalekoff S, Tiemessen CT, Gray CM, Martin DJ, (1998) Depressed phagocytosis and oxidative burst in polymorphonuclear leukocytes from individuals with pulmonary tuberculosis with or without human immunodeficiency virus type 1 infection. Clinical and Vaccine Immunology 5: 41-44.
26. Fiorenza G, Bottasso OA, Rateni L, Farroni MA, Dlugovitzky D, (2003) Impaired neutrophil function in patients with pulmonary tuberculosis and its normalization in those undergoing specific treatment, except the HIV-coinfected cases. FEMS Immunology & Medical Microbiology 35: 159-164 doi:10.1016/S0928-8244(03)00004-X.
27. Fiorenza G, Farroni MA, Bogué C, Selenscig D, Lamas DM, et al. (2007) Functional characteristics of neutrophils and mononuclear cells from tuberculosis patients stimulated in vitro with heat killed M. tuberculosis. Arch Med Res 38: 526-533 doi:10.1016/j.arcmed.2007.01.011.