Ketamine and atropine for pediatric sedation: A prospective double-blind randomized controlled trial

Pediatric Emergency Care

Volumn 29, Issue 2, 2013, Pages 136-139

  Asadi, Payman ^a   Ghafouri, Hamed Basir ^b   Yasinzadeh, Mohammadreza ^b   Kasnavieh, Seid Mohamad Hosseini ^b   Modirian, Ehsan ^b  

^a GUILAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Atropine; Ketamine; Sedation

Indexed keywords

ATROPINE; KETAMINE; OXYGEN; PLACEBO; WATER;

ADOLESCENT; APNEA; ARTICLE; CHILD; CONSCIOUS SEDATION; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG ERUPTION; DRUG SAFETY; EMERGENCY WARD; FEMALE; FRACTURE REDUCTION; HUMAN; HYPERSALIVATION; INTRAVENOUS ANESTHESIA; LARYNX SPASM; MAJOR CLINICAL STUDY; MALE; MOTOR DYSFUNCTION; MUSCLE SPASM; NAUSEA AND VOMITING; OXYGEN SATURATION; PEDIATRIC ANESTHESIA; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SIDE EFFECT; TACHYCARDIA; TREATMENT DURATION; WOUND CARE;

ADJUVANTS, ANESTHESIA; ADOLESCENT; ANESTHETICS, DISSOCIATIVE; ATROPINE; CHI-SQUARE DISTRIBUTION; CHILD; CHILD, PRESCHOOL; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INFANT; KETAMINE; MALE; PROSPECTIVE STUDIES; SALIVATION;

EID: 84879968688     PISSN: 07495161     EISSN: 15351815     Source Type: Journal    
DOI: 10.1097/PEC.0b013e31828058b2     Document Type: Article

References (19)

1. Doyle E. Emergency analgesia in the paediatric population. Part IV paediatric sedation in the accident and emergency department: pros and cons. Emerg Med J. 2002;19:284-287.
2. Shehata HA, Gupta S. Neurological disorders in pregnancy. Current Women's Health Reviews. 2011;7:217-225.
3. Mace SE, Barata IA, Cravero JP, et al. Clinical policy: evidence-based approach to pharmacologic agents used in pediatric sedation and analgesia in the emergency department. J Emerg Nurs. 2004;30:447-461.
4. Visser E, Schug SA. The role of ketamine in pain management. Biomed Pharmacother. 2006;60:341-348.
5. Hall J, Collyer T. Ketamine sedation in children. Emerg Nurse. 2007;15:24-27.
6. Green SM, Krauss B. Clinical practice guideline for emergency department ketamine dissociative sedation in children. Ann Emerg Med. 2004;44:460-471.
7. Maurice SC, O'Donnell JJ, Beattie TF. Emergency analgesia in the paediatric population. Part II pharmacological methods of pain relief. Emerg Med J. 2002;19:101-105.
8. Morton NS. Ketamine for procedural sedation and analgesia in pediatric emergency medicine: a UK perspective. Paediatr Anaesth. 2008; 18:25-29.
9. McGlone RG, Howes MC, Joshi M. The Lancaster experience of 2.0 to 2.5 mg/kg intramuscular ketamine for paediatric sedation: 501 cases and analysis. Emerg Med J. 2004;21:290-295.
10. Green SM, Rothrock SG, Lynch EL, et al. Intramuscular ketamine for pediatric sedation in the emergency department: safety profile in 1, 022 cases. Ann Emerg Med. 1998;31:688-697.
11. Green SM, Roback MG, Krauss B. Laryngospasm during emergency department ketamine sedation: a case-control study. Pediatr Emerg Care. 2010;26:798-802.
12. Roback MG, Wathen JE, Bajaj L, et al. Adverse events associated with procedural sedation and analgesia in a pediatric emergency department: a comparison of common parenteral drugs. Acad Emerg Med. 2005;12:508-513.
13. Green SM, Rothrock SG, Harris T, et al. Intravenous ketamine for pediatric sedation in the emergency department: safety profile with 156 cases. Acad Emerg Med. 1998;5:971-976.
14. Green SM, Roback MG, Krauss B. Anticholinergics and ketamine sedation in children: a secondary analysis of atropine versus glycopyrrolate. Acad Emerg Med. 2010;17:157-162.
15. Heinz P, Geelhoed GC, Wee C, et al. Is atropine needed with ketamine sedation? A prospective, randomised, double blind study. Emerg Med J. 2006;23:206-209.
16. Brown L, Christian-Kopp S, Sherwin TS, et al. Adjunctive atropine is unnecessary during ketamine sedation in children. Acad Emerg Med. 2008;15:314-318.
17. Hiremath PS, Bhonsle SA, Thumma S, et al. Recent patents on oral combination drug delivery and formulations. Recent Pat Drug Deliv Formul. 2011;5:52-60.
18. Cote CJ, Wilson S. Guidelines for monitoring and management of pediatric patients during and after sedation for diagnostic and therapeutic procedures: an update. Pediatrics. 2006;118:2587-2602.
19. Sury M, Bullock I, Rabar S, et al. Sedation for diagnostic and therapeutic procedures in children and young people: summary of NICE guidance. BMJ. 341:c6819.