Absence of Mutations in Exon 6 of the TARDBP Gene in 207 Chinese Patients with Sporadic Amyotrohic Lateral Sclerosis

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Ye, Cheng hui ^a   Lu, Xi lin ^a,b   Zheng, Min ying ^a   Zhen, Jun ^a   Li, Zhi Ping ^a   Shi, Lei ^a,b   Liu, Zhi yong ^a   Feng, Lu yang ^a,b   Pei, Zhong ^a,b   Yao, Xiao li ^a,c,d  

^a SUN YAT SEN UNIVERSITY   (China)

^b Guangdong key laboratory for diagnosis and treatment of major neurological diseases   (China)

^c The Neurosurgery Institute of Guangdong Province   (China)

^d National Key Discipline   (China)

Author keywords

[No Author keywords available]

Indexed keywords

TAR DNA BINDING PROTEIN;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; ASIA; CHINESE; CONTROLLED STUDY; EXON; FEMALE; GENE MUTATION; GENE SEQUENCE; HUMAN; MAJOR CLINICAL STUDY; MALE; MUTANT; MUTATION RATE;

ADULT; AMYOTROPHIC LATERAL SCLEROSIS; ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; DNA-BINDING PROTEINS; EXONS; FEMALE; GENETIC ASSOCIATION STUDIES; HUMANS; MALE; MIDDLE AGED; MUTATION;

EID: 84879945604     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0068106     Document Type: Article

References (13)

1. Ou SH, Wu F, Harrich D, Garcia-Martinez LF, Gaynor RB, (1995) Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs. J Virol 69: 3584-3596.
2. Arai T, Hasegawa M, Akiyama H, Ikeda K, Nonaka T, et al. (2006) TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem Biophys Res Commun 351: 602-611.
3. Zou ZY, Peng Y, Wang XN, Liu MS, Li XG, et al. (2012) Screening of the TARDBP gene in familial and sporadic amyotrophic lateral sclerosis patients of Chinese origin. Neurobiol Aging 33: 2211-2229.4.
4. Lagier-Tourenne C, Cleveland DW, (2009) Rethinking ALS: the FUS about TDP-43. Cell 136: 1001-1004.
5. Brooks BR, Miller RG, Swash M, Munsat TL, (2000) El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 1: 293-299.
6. Xiong HL, Wang JY, Sun YM, Wu JJ, Chen Y, et al. (2010) Association between novel TARDBP mutations and Chinese patients with amyotrophic lateral sclerosis. BMC Med Genet 11: 8.
7. Paul M, Murray V, (2012) Use of an automated capillary DNA sequencer to investigate the interaction of cisplatin with telomeric DNA sequences. Biomed Chromatogr 26: 350-354.
8. Huang R, Fang DF, Ma MY, Guo XY, Zhao B, et al. (2012) TARDBP gene mutations among Chinese patients with sporadic amyotrophic lateral sclerosis. Neurobiol Aging 33: 1011-1015.
9. Lattante S, Rouleau GA, Kabashi E (2013) TARDBP and FUS Mutations Associated with Amyotrophic Lateral Sclerosis: Summary and Update. Hum Mutat.
10. Tsai CP, Soong BW, Lin KP, Tu PH, Lin JL, et al. (2011) FUS, TARDBP, and SOD1 mutations in a Taiwanese cohort with familial ALS. Neurobiol Aging 32: 513-553.
11. Van Deerlin VM, Leverenz JB, Bekris LM, Bird TD, Yuan W, et al. (2008) TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis. Lancet Neurol 7: 409-416.
12. Iida A, Kamei T, Sano M, Oshima S, Tokuda T, et al. (2012) Large-scale screening of TARDBP mutation in amyotrophic lateral sclerosis in Japanese. Neurobiol Aging 33: 786-790.
13. Guerreiro RJ, Schymick JC, Crews C, Singleton A, Hardy J, et al. (2008) TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis. PLoS One 3: e2450.