Legionella pneumophila in healthcare facilities

Reviews and Research in Medical Microbiology

Volumn 24, Issue 3, 2013, Pages 70-80

  Spagnolo, Anna Maria ^a   Cristina, Maria Luisa ^a   Casini, Beatrice ^b   Perdelli, Fernanda ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

aerosols; Legionella pneumophila; nosocomial legionellosis

Indexed keywords

AZITHROMYCIN; CLARITHROMYCIN; DRINKING WATER; ERYTHROMYCIN; LEVOFLOXACIN; QUINOLONE DERIVATIVE;

ARTICLE; BACTERIAL TRANSMISSION; COST EFFECTIVENESS ANALYSIS; ENZYME IMMUNOASSAY; HEALTH CARE FACILITY; HOSPITAL INFECTION; LABORATORY DIAGNOSIS; LABORATORY TEST; LEGIONELLA LONGBEACHAE; LEGIONELLA PNEUMOPHILA; LEGIONNAIRE DISEASE; PATIENT SAFETY; PRIORITY JOURNAL; WATER MANAGEMENT;

EID: 84879935384     PISSN: 0954139X     EISSN: 14735601     Source Type: Journal    
DOI: 10.1097/MRM.0b013e328362fe66     Document Type: Article

References (79)

1. World Health Organization. Guidelines for drinking-water quality. 4th ed. Geneva: WHO Press; 2011.
2. Diederen BM, de Jong CM, Marmouk F, Kluytmans JA, Peeters MF, Van der Zee A. Evaluation of real-time PCR for the early detection of Legionella pneumophila DNA in serum samples. J Med Microbiol 2007; 56:94-101. (Pubitemid 46036281)
3. Health and Safety Executive. Legionnaires' disease. The control of legionella bacteria in water systems. Approved Code of Practice and Guidance. 4th ed. Health and Safety Executive; 2000.
4. Mathys W, Stanke J, Harmuth M, Junge-Mathys E. Occurrence of Legionella in hot water systems of single-family residences in suburbs of two German cities with special reference to solar and district heating. Int J Hyg Environ Health 2008; 211:179-185. (Pubitemid 351249203)
5. Bartram J, Chartier Y, Lee JV, Pond K, Surman-Lee S. Legionella and the prevention of legionellosis. Geneva: WHO Press; 2007.
6. Messi P, Bargellini A, Anacarso I, Marchesi I, de Niederhäusern S, Bondi M. Protozoa and human macrophages infection by Legionella pneumophila environmental strains belonging to different serogroups. Arch Microbiol 2013; 195:89-96.
7. Rowbotham TJ. Preliminary report on the pathogenicity of Legionella pneumophila for freshwater and soil amoebae. J Clin Pathol 1980; 33:1179-1183. (Pubitemid 11160649)
8. Gomez-Valero L, Rusniok C, Buchrieser C. Legionella pneumophila: population genetics, phylogeny and genomics. Infect Genet Evol 2009; 9:727-739.
9. Koubar M, Rodier MH, Frère J. Involvement of minerals in adherence of Legionella pneumophila to surfaces. Curr Microbiol 2013; 66:437-442.
10. Borella P, Montagna MT, Romano-Spica V, Stampi S, Stancanelli G, Triassi M, et al. Relationship between mineral content of domestic hot water and microbial contamination. J Trace Elem Med Biol 2003; 17:37-43. (Pubitemid 37432562)
11. Duncan C, Prashar A, So J, Tang P, Low DE, Terebiznik M, et al. Lcl of Legionella pneumophila is an immunogenicGAGbinding adhesin that promotes interactions with lung epithelial cells and plays a crucial role in biofilm formation. Infect Immun 2011; 79:2168-2181.
12. Fields BS, Benson RF, Besser RE. Legionella and Legionnaires' disease: 25 years of investigation. Clin Microbiol Rev 2002; 15:506-526. (Pubitemid 34761355)
13. Reuter S, Harrison TG, Köser CU, Ellington MJ, Smith GP, Parkhill J, et al. A pilot study of rapid whole-genome sequencing for the investigation of a Legionella outbreak. BMJ Open 2013; 3:pii: e002175.
14. Cazalet C, Rusniok C, Brüggemann H, Zidane N, Magnier A, Ma L, et al. Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity. Nat Genet 2004; 36:1165-1173. (Pubitemid 41288965)
15. Chaabna Z, Forey F, Reyrolle M, Jarraud S, Atlan D, Fontvieille D, et al. Molecular diversity and high virulence of Legionella pneumophila strains isolated from biofilms developed within a warm spring of a thermal spa. BMC Microbiol 2013; 13:17.
16. Clemens DL, Horwitz MA. Hypoexpression of major histocompatibility complex molecules on Legionella pneumophila phagosomes and phagolysosomes. Infect Immun 1993; 61:2803-2812. (Pubitemid 23182272)
17. Horwitz MA. Toward an understanding of host and bacterial molecules mediating pathogenesis. In: Barbaree JM, Breiman RF, Doufur AF,editors. Legionella: current status and emerging perspectives Washington, DC: American Society for Microbiology; 1993. pp. 55-62.
18. Boshuizen HC, Neppelenbroek SE, van Vliet H, Schellekens JF, den Boer JW, Peeters MF, et al. Subclinical Legionella infection in workers near the source of a large outbreak of legionnaires disease. J Infect Dis 2001; 184:515-518. (Pubitemid 32718518)
19. McDade JE, Shepard CC, Fraser DW, Tsai TR, Redus MA, Dowdle WR. Legionnaires' disease: isolation of a bacterium and demonstration of its role in other respiratory disease. N Engl J Med 1977; 297:1197-1203. (Pubitemid 8226680)
20. Lin YE, Stout JE, Yu VL. Prevention of hospital-acquired legionellosis. Curr Opin Infect Dis 2011; 24:350-356.
21. Wright AJ, Humar A, Gourishankar S, Bernard K, Kumar D. Severe Legionnaires' disease caused by Legionella longbeachae in a long-term renal transplant patient: the importance of safe living strategies after transplantation. Transpl Infect Dis 2012; 14:E30-33.
22. Bull M, Hall IM, Leach S, Robesyn E. The application of geographic information systems and spatial data during Legionnaires disease outbreak responses. Euro Surveill 2012; 17:pii: 20331.
23. Sabria M, Yu VL. Hospital-acquired legionellosis: solutions for a preventable infection. Lancet Infect Dis 2002; 2:368-373. (Pubitemid 34595977)
24. Gutierrez F, Oritz V, Martinez C, Masia MM, Chiner E, Calpe JL. Legionnaires' disease in patients with human immunodeficiency virus. Clin Infect Dis 1995; 21:712-713.
25. Benin AL, Benson RF, Besser RE. Trends in Legionnaires' disease, 1980-1998: declining mortality and new patterns of diagnosis. Clin Infect Dis 2002; 35:1039-1046. (Pubitemid 35239462)
26. Yu VL, Plouffe JF, Pastoris MC, Stout JE, Schousboe M, Widmer A, et al. Distribution of Legionella species and serogroups isolated by culture in patients with sporadic communityacquired legionellosis: an international collaborative survey. J Infect Dis 2002; 186:127-128. (Pubitemid 34666926)
27. Quaranta G, Vincenti S, Ferriero AM, Boninti F, Sezzatini R, Turnaturi C, et al. Legionella on board trains: effectiveness of environmental surveillance and decontamination. BMC Public Health 2012; 12:618.
28. Mencacci A, Corbucci C, Castellani A, Furno P, Bistoni F, Vecchiarelli A. Legionella pneumophila serogroup 3 pneumonia in a patient with low-grade 4 non-Hodgkin lymphoma: a case report. J Med Case Rep 2011; 5:387.
29. Rota MC, Caporali MG, Giannitelli S, Mandarino G, Scaturro M, Ricci ML. Legionellosis in Italy in 2009: annual report. Ann Istituto Superiore di Sanità 2010; 23:3-10.
30. Borella P, Montagna MT, Romano-Spica V, Stampi S, Stancanelli G, Triassi M, et al. Legionella infection risk from domestic hot water. Emerg Infect Dis 2004; 10:457-464. (Pubitemid 38314472)
31. Borella P, Montagna MT, Stampi S, Stancanelli G, Romano-Spica V, Triassi M, et al. Legionella contamination in hot water of Italian hotels. Appl Environ Microbiol 2005; 71:5805-5813. (Pubitemid 41456871)
32. Ricketts K, Joseph CA, Yadav R. Travel-associated Legionnaires' disease in Europe in 2008. On behalf of the European Working Group for Legionella infections. Euro Surveill 2010; 15:19578.
33. Thacker SB, Bennett JV, Tsai TF, Fraser DW, McDade JE, Shepard CC, et al. An outbreak in 1965 of severe respiratory illness caused by the Legionnaires' disease bacterium. J Infect Dis 1978; 138:512-519. (Pubitemid 9032746)
34. Cunha BA, Thekkel V, Schoch PE. Community-acquired versus nosocomial Legionella pneumonia: lessons learned from an epidemiologic investigation. Am J Infect Control 2011; 39:901-903.
35. Casini B, Valentini P, Baggiani A, Torracca F, Frateschi S, Nelli LC, et al. Molecular epidemiology of Legionella pneumophila serogroup 1 isolates following long-term chlorine dioxide treatment in a university hospital water system. J Hosp Infect 2008; 69:141-147.
36. Ozerol IH, Bayraktar M, Cizmeci Z, Durmaz R, Akbas E, Yildirim Z, et al. Legionnaires' disease: a nosocomial outbreak in Turkey. J Hosp Infect 2006; 62:50-57. (Pubitemid 43103010)
37. Stypułkowska-Misiurewicz H, Pancer K, Krogulska B, Matuszewska R. Outbreak of hospital acquired Legionnaires' disease in patients of ophthalmic ward. Nosocomial Legionella infections for the first time observed in Poland. Przegl Epidemiol 2007; 61:657-665.
38. Tobin JO, Swann RA, Bartlett CL. Isolation of Legionella pneumophila from water systems: methods and preliminary results. Br Med J 1981; 282:515-517. (Pubitemid 11188761)
39. Stout J, Yu VL, Vickers RM, Shonnard J. Potable water supply as the hospital reservoir for Pittsburgh pneumonia agent. Lancet 1982; 1:471-472. (Pubitemid 12171139)
40. Lin YE, Stout JE, Yu VL. Controlling Legionella in hospital drinking water: an evidence-based review of disinfection methods. Infect Control Hosp Epidemiol 2011; 32:166-173.
41. Garbe PL, Davis BJ, Weisfeld JS, Markowitz L, Miner P, Garrity F, et al. Nosocomial Legionnaires' disease. Epidemiologic demonstration of cooling towers as a source. J Am Med Assoc 1985; 254:521-524. (Pubitemid 15025435)
42. Vincent-Houdek M, Muytjens HL, Bongaerts GP, van Ketel RJ. Legionella monitoring: a continuing story of nosocomial infection prevention. J Hosp Infect 1993; 25:117-124. (Pubitemid 23337271)
43. Bou R, Ramos P. Outbreak of nosocomial Legionnaires' disease caused by a contaminated oxygen humidifier. J Hosp Infect 2009; 71:381-383.
44. Cristina ML, Spagnolo AM, Sartini M, Dallera M, Ottria G, Lombardi R, et al. Evaluation of the risk of infection through exposure to aerosols and spatters in dentistry. Am J Infect Control 2008; 36:304-307. (Pubitemid 351608719)
45. Cristina ML, Spagnolo AM, Sartini M, Dallera M, Ottria G, Perdelli F, et al. Investigation of organizational and hygiene features in dentistry: a pilot study. J Prev Med Hyg 2009; 50:175-180.
46. Perdelli F, Spagnolo AM, Cristina ML, Sartini M, Malcontenti R, Dallera M, et al. Evaluation of contamination by blood aerosols produced during various healthcare procedures. J Hosp Infect 2008; 70:174-179.
47. Ma'ayeh SY, Al-Hiyasat AS, Hindiyeh MY, Khader YS. Legionella pneumophila contamination of a dental unit water line system in a dental teaching centre. Int J Dent Hyg 2008; 6:48-55.
48. Veronesi L, Capobianco E, Affanni P, Pizzi S, Vitali P, Tanzi ML. Legionella contamination in the water system of hospital dental settings. Acta Biomed 2007; 78:117-122.
49. Ricci ML, Fontana S, Pinci F, Fiumana E, Pedna MF, Farolfi P, et al. Pneumonia associated with a dental unit waterline. Lancet 2012; 379:684.
50. Haupt TE, Heffernan RT, Kazmierczak JJ, Nehls-Lowe H, Rheineck B, Powell C, et al. An outbreak of Legionnaires disease associated with a decorative water wall fountain in a hospital. Infect Control Hosp Epidemiol 2012; 33:185-191.
51. Palmore TN, Stock F, White M, Bordner M, Michelin A, Bennett JE, et al. A cluster of cases of nosocomial legionnaires disease linked to a contaminated hospital decorative water fountain. Infect Control Hosp Epidemiol 2009; 30:764-768.
52. Diederen BM. Legionella spp. and Legionnaires' disease. J Infect 2008; 56:1-12. (Pubitemid 350253650)
53. Formica N, Yates M, Beers M, Carnie J, Hogg G, Ryan N, et al. The impact of diagnosis by legionella urinary antigen test on the epidemiology and outcomes of Legionnaires' disease. Epidemiol Infect 2001; 127:275-280. (Pubitemid 33019539)
54. Murdoch DR. Diagnosis of Legionella infection. Clin Infect Dis 2003; 36:64-69. (Pubitemid 36099099)
55. Den Boer JW, Yzerman EP. Diagnosis of Legionella infection in Legionnaires' disease. Eur J Clin Microbiol Infect Dis 2004; 23:871-878. (Pubitemid 40104740)
56. Joseph C. Surveillance of Legionnaires disease in Europe. In: Marre R et al., editors. Legionella. Washington, DC: ASM Press; 2002. pp. 311-320.
57. Sopena N, Sabrià M, Pedro-Botet ML, Reynaga E, Garća-Núñez M, Doḿnguez J, et al. Factors related to persistence of Legionella urinary antigen excretion in patients with Legionnaires' disease. Eur J Clin Microbiol Infect Dis 2002; 21:845-848. (Pubitemid 36160709)
58. Lück PC, Igel L, Helbig JH, Kuhlisch E, Jatzwauk L. Comparison of commercially available media for the recovery of Legionella species. Int J Hyg Environ Health 2004; 207:589-593. (Pubitemid 40824337)
59. Carratalà J, Garcia-Vidal C. An update on Legionella. Curr Opin Infect Dis 2010; 23:152-157.
60. Uldum SA, Molbak K. PCR as a routine method for diagnosis of Legionnaires' disease. In: Marre R et al., editors. Legionella. Washington, DC: ASM Press; 2002. pp. 213-215.
61. Sabrià M, Pedro-Botet ML, Gómez J, Roig J, Vilaseca B, Sopena N, et al. Fluoroquinolones vs. macrolides in the treatment of Legionnaires' disease. Chest 2005; 3:1401-1405. (Pubitemid 41324424)
62. Fiore AE, Butler JC, Emori TG, Gaynes RP. A survey of methods used to detect nosocomial legionellosis among participants in the National Nosocomial Infection Surveillance System. Infect Control Hosp Epidemiol 1999; 20:412-441.
63. Bartlett JG, Breiman RF, Mandell LA, File TM. Communityacquired pneumonia in adults: guidelines for management. The Infectious Diseases Society of America. Clin Infect Dis 1998; 26:811-838. (Pubitemid 28180966)
64. Plouffe JF, Breiman RF, Fields BS, Herbert M, Inverso J, Knirsch C, et al. Azithromycin in the treatment of Legionella pneumonia requiring hospitalization. Clin Infect Dis 2003; 37:1475-1480. (Pubitemid 37494675)
65. Mykietiuk A, Carratalà J, Fernández-Sabé N, Dorca J, Verdaguer R, Manresa F, et al. Clinical outcomes for hospitalized patients with Legionella pneumonia in the antigenuria era: the influence of levofloxacin therapy. Clin Infect Dis 2005; 40:794-799. (Pubitemid 40365496)
66. Williams MM, Armbruster CR, Arduino MJ. Plumbing of hospital premises is a reservoir for opportunistically pathogenic microorganisms: a review. Biofouling 2013; 29:147-162.
67. Dyck A, Exner M, Kramer A. Experimental based experiences with the introduction of a water safety plan for a multilocated university clinic and its efficacy according to WHO recommendations. BMC Public Health 2007; 7:34.
68. Squier CL, Stout JE, Krsytofiak S, McMahon J, Wagener MM, Dixon B, et al. A proactive approach to prevention of healthcare-acquired Legionnaires' disease: the Allegheny County (Pittsburgh) experience. Am J Infect Control 2005; 33:360-367. (Pubitemid 41074580)
69. Centers for Disease Control and Prevention. Guidelines for preventing health-care-associated pneumonia, 2003. Recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee. MMWR Recomm Rep 2004; 53:1-36.
70. Boccia S, Laurenti P, Borella P, Moscato U, Capalbo G, Cambieri A, et al. Prospective 3-year surveillance for nosocomial and environmental Legionella pneumophila: implications for infection control. Infect Control Hosp Epidemiol 2006; 27:459-465. (Pubitemid 43835527)
71. Pleischl S, Krizek L, Exner M. Cooling towers and evaporative condensers as infection reservoir: hygienic-microbiological results. Umweltmedizin in Forschung und Praxis 2002; 7:200-220.
72. Cristino S, Legnani PP, Leoni E. Plan for the control of Legionella infections in long-term care facilities: role of environmental monitoring. Int J Hyg Environ Health 2012; 215:279-285.
73. Exner M, Kramer A, Lajoie L, Gebel J, Engelhart S, Hartemann P. Prevention and control of healthcare-associated waterborne infections in healthcare facilities. Am J Infect Control 2005; 33:26-40.
74. Sydnor ER, Bova G, Gimburg A, Cosgrove SE, Perl TM, Maragakis LL. Electronic-eye faucets: Legionella species contamination in healthcare settings. Infect Control Hosp Epidemiol 2012; 33:235-240.
75. Halabi M, Wiesholzer-Pittl M, Schö berl J, Mittermayer H. Nontouch fittings in hospitals: a possible source of Pseudomonas aeruginosa and Legionella spp. J Hosp Infect 2001; 49:117-121. (Pubitemid 32982685)
76. Leprat R, Denizot V, Bertrand X, Talon D. Nontouch fittings in hospitals: a possible source of Pseudomonas aeruginosa and Legionella spp. J Hosp Infect 2003; 53:77. (Pubitemid 38002092)
77. Marchesi I, Marchegiano P, Bargellini A, Cencetti S, Frezza G, Miselli M, et al. Effectiveness of different methods to control legionella in the water supply: ten-year experience in an Italian university hospital. JHosp Infect 2011; 77:47-51.
78. Garća MT, Baladrón B, Gil V, Tarancon ML, Vilasau A, Ibañez A, et al. Persistence of chlorine-sensitive Legionella pneumophila in hyperchlorinated installations. J Appl Microbiol 2008; 105:837-847.
79. Zhang Z, McCann C, Stout JE, Piesczynski S, Hawks R, Vidic R, et al. Safety and efficacy of chlorine dioxide for Legionella control in a hospital water system. Infect Control Hosp Epidemiol 2007; 28:1009-1012. (Pubitemid 47218285)