Efficacy of Gastrosis No.1 compound on functional dyspepsia of spleen and stomach deficiency-cold syndrome: A multi-center, double-blind, placebo-controlled clinical trial

Chinese Journal of Integrative Medicine

Volumn 19, Issue 7, 2013, Pages 498-504

  Zhang, Sheng Sheng ^a   Zhao, Lu Qing ^a   Wang, Hong Bing ^a   Wu, Bing ^a   Wang, Chui Jie ^b   Huang, Sui Ping ^c   Shen, Hong ^d   Wei, Wei ^e   Lai, Yao Liang ^f  

^a BEIJING HOSPITAL OF TRADITIONAL CHINESE MEDICINE AFFILIATED TO CAPITAL MEDICAL UNIVERSITY   (China)

^b LIAONING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^c GUANGDONG PROVINCIAL HOSPITAL OF CHINESE MEDICINE   (China)

^d NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^e WANGJING HOSPITAL   (China)

^f Beijing Xuanwu TCM Hospital   (China)

Author keywords

functional dyspepsia; randomized controlled trial; Spleen and Stomach deficiency cold syndrome

Indexed keywords

CHINESE DRUG; GASTROSIS NUMBER 1 COMPOUND; HERBACEOUS AGENT; PLACEBO; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CHINESE MEDICINE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DYSPEPSIA; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SPLEEN DEFICIENCY COLD SYNDROME; SPLEEN DISEASE; STOMACH DEFICIENCY COLD SYNDROME; STOMACH DISEASE; TREATMENT DURATION; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT;

ADULT; DOUBLE-BLIND METHOD; DRUGS, CHINESE HERBAL; DYSPEPSIA; FEMALE; HUMANS; MALE; PLACEBOS; SPLEEN; STOMACH; SYNDROME; TREATMENT OUTCOME;

EID: 84879921557     PISSN: 16720415     EISSN: 19930402     Source Type: Journal    
DOI: 10.1007/s11655-013-1503-x     Document Type: Article

References (25)

1. Shaib Y, El-Serag HB. The prevalence and risk factors of functional dyspepsia in a multiethnic population in the United States. Am J Gastroenterol 2004;99:2210-2216.
2. Bernersen B, Johnsen R, Straume B. Non-ulcer dyspepsia and peptic ulcer: the distribution in a population and their relation to risk factors. Gut 1996;38:822-825.
3. Hirakawa K, Adachi K, Amano K, Katsube T. Prevalence of non-ulcer dyspepsia in the Japanese population. J Gastroenterol Hepatol 1999;14:1083-1087.
4. Lu CL, Lang HC, Chang FY. Prevalence and health/social impacts of functional dyspepsia in Taiwan: a study based on the Rome criteria questionnaire survey assisted by endoscopic exclusion among a physical check-up population. Scand J Gastroenterol 2005;40:402-411.
5. Brook RA, Kleinman NL, Choung RS. Excess comorbidity prevalence and cost associated with functional dyspepsia in an employed population. Dig Dis Sci 2011;13:109-118.
6. Brook RA, Kleinman NL, Choung RS. Functional dyspepsia impacts absenteeism and direct and indirect costs. Clin Gastroenter Hepatol 2010;8:498-503.
7. Tack J, Lee KJ. Pathophysiology and treatment of functional dyspepsia. J Clin Gastroenterol 2005;39(5 Suppl 3):S211-216.
8. Lee KJ, Tack J. Duodenal implications in the pathophysiology of functional dyspepsia. J Neurogastroenterol Motil 2010;16:251-257.
9. Zeng F, Qin W, Liang F. Abnormal resting brain activity in patients with functional dyspepsia is related to symptom severity. Gastroenterology 2011;141:499-506.
10. Savarino E, Zentilin P, Dulbecco P. The role of acid in functional dyspepsia. Am J Gastroenterol 2011;106:1168.
11. Zhang SS, Su DM, Zhao LQ. Systematic review on the efficacy of TCM in the treatment of functional dyspepsia. Chin J Integr Tradit West Med Digestion (Chin) 2011;23:32-34.
12. Rome Foundation. Guidelines-Rome III diagnostic criteria for functional gastrointestinal disorders. J Gastrointestin Liver Dis 2006;15:307-312.
13. Zheng XY. Guiding principle of clinical research on new drugs of Chinese medicine in the treament of stuffiness and fullness. In guiding principle of clinical research on new drugs of Chinese medicine (trial implementation). Edited by: Yu XH. Bejing: Chinese Medical Science and Technology Press; 2002:54-58.
14. Liu X. Experimental design and data processing (fourth). Chin J Difficult Complicated Cases (Chin) 2003;2:55-57.
15. Zhang YP, Luo JH, Zhou C. The clinical curative effect of Jianpi Oral Liquid on 87 cases of Spleen and Stomach deficiency-weakness syndrome. Chin Tradit Patent Med (Chin) 1999;21:239-242.
16. Holtmann G, Talley NJ, Liebregts T, Adam B, Parow C. A placebo-controlled trial of itopride in functional dyspepsia. New Engl J Med 2006;354:832-840.
17. Oshima T, Miwa H. Treatment of functional dyspepsia: where to go and what to do. J Gastroenterol 2006;41:647-653.
18. Mönkemüller K, Malfertheiner P. Drug treatment of functional dyspepsia. World J Gastroenterol 2006;12:2694-2700.
19. Hojo M, Miwa H, Yokoyama. Treatment of functional dyspepsia with antianxiety or antidepressive agents: systematic review. J Gastroenterol 2005;40:1036-1042.
20. Talley NJ, Locke GR, Lahr BD. Predictors of the placebo response in functional dyspepsia. Aliment Pharmacol Ther 2006;23:923-936.
21. Zhao BG, Sun QF. Modern pharmacological studies and clinic application of Lizhong Bolus. Chin Tradit Patent Med (Chin) 2010;32:1957-1960.
22. Guo JC, Zhang AJ, Zheng XH, Zhou QF. Experimental study of complex Dangshen ventilation oral solution on intestinal function recovery after operation on abdominal region. J Emerg Tradit Chin Med (Chin) 2007;16:1238-1240.
23. Song D, Wang ZT, Li LY, Zhong GY. Protective effect of lobetyolin on gastric mucosa of experimental gastric ulcer in rats. J Emerg Tradit Chin Med (Chin) 2008;17:963-964.
24. Chan LW, Cheah EL, Saw CL. Antimicrobial and antioxidant activities of Cortex Magnoliae Officinalis and some other medicinal plants commonly used in south-east Asia. Chin Med 2008;28:3-15.
25. Liu CB, Zhang SC, Li QT. The development of modern pharmacological research of rhizoma cyperi. Guangming J Chin Med (Chin) 2009;24:787-788.