Re-invigorating the insecticide discovery pipeline for vector control: GPCRs as targets for the identification of next gen insecticides

Pesticide Biochemistry and Physiology

Volumn 106, Issue 3, 2013, Pages 141-148

  Hill, Catherine A ^a   Meyer, Jason M ^a   Ejendal, Karin F K ^b   Echeverry, Diego F ^a   Lang, Emma G ^a   Avramova, Larisa V ^a   Conley, Jason M ^b   Watts, Val J ^b  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

Agonist; Antagonist; Dopamine receptor; G protein coupled receptor; Insecticide discovery; Mosquito

Indexed keywords

AEDES AEGYPTI; ANOPHELES GAMBIAE; CULEX PIPIENS PIPIENS; CULEX PIPIENS QUINQUEFASCIATUS; HEXAPODA; INVERTEBRATA; IXODES SCAPULARIS; IXODIDA; VERTEBRATA;

EID: 84879884897     PISSN: 00483575     EISSN: 10959939     Source Type: Journal    
DOI: 10.1016/j.pestbp.2013.02.008     Document Type: Article

References (11)

1. Hemingway J., Ranson H. Insecticide resistance in insect vectors of human disease. Annu. Rev. Entomol. 2011, 45:371-391.
2. Hemingway J., Beaty B.J., Rowland M., Scott T.W., Sharp B.L. The innovative vector control consortium: improved control of mosquito-borne diseases. Trends Parasitol. 2006, 22:308-312.
3. Frye S., Crosby M., Edwards T., Juliano R. US academic drug discovery. Nat. Rev. Drug Discovery 2011, 10:409-410.
4. Stevens A.J., Jensen J.J., Wyller K., Kilgore P.C., Chatterjee S., Rohrbaugh M.L. The role of public-sector research in the discovery of drugs and vaccines. N. Engl. J. Med. 2011, 364:535-541.
5. Filmore D. It's a GPCR world. Mod. Drug Discovery 2004, 7:24-28.
6. Taneja-Bageshwar S., Strey A., Isaac R.E., Coast G.M., Zubrzak P., Pietrantonio P.V., Nachman R.J. Biostable agonists that match or exceed activity of native insect kinins on recombinant arthropod GPCRs. Gen. Comp. Endocrinol. 2009, 162:122-128.
7. 1-like dopamine receptors. PLoS Negl. Trop. Dis. 2012, 6(1):e1478.
8. Meyer J.M., Ejendal K.F.K., Watts V.J., Hill C.A. Molecular and pharmacological characterization of two D1-like dopamine receptors in the Lyme disease vector, Ixodes scapularis. Insect Biochem. Mol. Biol. 2011, 41:563-571.
9. Ejendal K.F.K., Meyer J.M., Brust T., Avramova L.V., Hill C.A., Watts V.J. Discovery of potent antagonists of tick dopamine receptors via chemical library screening and comparative pharmacological analyses. Insect Biochem. Mol. Biol. 2012, 42:846-853.
10. Chen A.C., He H., Davey R.B. Mutations in a putative octopamine receptor gene in amitraz-resistant cattle ticks. Vet. Parasitol. 2007, 148:379-383.
11. Kneller R. The importance of new companies for drug discovery: origins of a decade of new drugs. Nat. Rev. Drug Discovery 2010, 9:867-882.