Endothelial activation biomarkers increase after HIV-1 acquisition: Plasma vascular cell adhesion molecule-1 predicts disease progression

AIDS

Volumn 27, Issue 11, 2013, Pages 1803-1813

  Graham, Susan M ^a,b   Rajwans, Nimerta ^c   Jaoko, Walter ^b   Estambale, Benson B A ^d   McClelland, R Scott ^a,b   Overbaugh, Julie ^e   Liles, W Conrad ^a,c,f  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF NAIROBI   (Kenya)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF NAIROBI   (Kenya)

^e Fred Hutchinson Cancer Research Center   (United States)

^f UNIVERSITY OF TORONTO   (Canada)

Author keywords

angiopoietin 1; angiopoietin 2; E selectin; endothelial activation; HIV 1; intercellular adhesion molecule 1; vascular cell adhesion molecule 1

Indexed keywords

ANGIOPOIETIN 1; ANGIOPOIETIN 2; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; VASCULAR CELL ADHESION MOLECULE 1; VIRUS RNA;

ADULT; ANTIVIRAL THERAPY; ARTICLE; DEATH; DISEASE COURSE; DISEASE DURATION; ENDOTHELIUM; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; KENYA; MAJOR CLINICAL STUDY; MEASUREMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; SEROCONVERSION; VIRUS LOAD;

ADULT; ANGIOPOIETIN-1; ANGIOPOIETIN-2; BIOLOGICAL MARKERS; CD4 LYMPHOCYTE COUNT; DISEASE PROGRESSION; E-SELECTIN; FEMALE; FOLLOW-UP STUDIES; HIV INFECTIONS; HIV-1; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; KENYA; PLASMA; PROSPECTIVE STUDIES; SURVIVAL ANALYSIS; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84879852019     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e328360e9fb     Document Type: Article

References (34)

1. Nixon DE, Landay AL. Biomarkers of immune dysfunction in HIV. Curr Opin HIV AIDS 2010; 5:498-503.
2. Kuller LH, Tracy R, Belloso W, De Wit S, Drummond F, Lane HC, et al. Inflammatory and coagulation biomarkers and mortality in patients with HIV infection. PLoS Med 2008; 5:e203.
3. Boulware DR, Hullsiek KH, Puronen CE, Rupert A, Baker JV, French MA, et al. Higher levels of CRP, D-dimer, IL-6, and hyaluronic acid before initiation of antiretroviral therapy (ART) are associated with increased risk of AIDS or death. J Infect Dis 2011; 203:1637-1646.
4. Ledwaba L, Tavel JA, Khabo P, Maja P, Qin J, Sangweni P, et al. Pre-ART levels of inflammation and coagulation markers are strong predictors of death in a South African cohort with advanced HIV disease. PLoS One 2012; 7:e24243.
5. Baker J, Quick H, Hullsiek KH, Tracy R, Duprez D, Henry K, et al. Interleukin-6 and D-dimer levels are associated with vascular dysfunction in patients with untreated HIV infection. HIV Med 2010; 11:608-609.
6. Yeo TW, Lampah DA, Gitawati R, Tjitra E, Kenangalem E, Piera K, et al. Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malaria. Proc Natl Acad Sci U S A 2008; 105: 17097-17102.
7. Davis JS, Yeo TW, Piera KA, Woodberry T, Celermajer DS, Stephens DP, et al. Angiopoietin-2 is increased in sepsis and inversely associated with nitric oxide-dependent microvascular reactivity. Crit Care 2010; 14:R89.
8. Gattegno L, Bentata-Peyssare M, Gronowski S, Chaouche K, Ferriere F. Elevated concentrations of circulating intercellular adhesion molecule 1 (ICAM-1) and of vascular cell adhesion molecule 1 (VCAM-1) in HIV-1 infection. Cell Adhes Commun 1995; 3:179-185.
9. Calza L, Pocaterra D, Pavoni M, Colangeli V, Manfredi R, Verucchi G, et al. Plasma levels of VCAM-1, ICAM-1, E-selectin, and P-selectin in 99 HIV-positive patients versus 51 HIVnegative healthy controls. J Acquir Immune Defic Syndr 2009; 50:430-432.
10. Graham S, Rajwans N, Tapia K, Jaoko W, Estambale B, McClelland S, et al. Angiopoietin-2 is elevated in advanced HIV-1 infection, decreases after antiretroviral therapy initiation, and is related to plasma HIV-1 RNA. Abstract 281, 19th Conference on Retroviruses and Opportunistic Infections: Seattle, Washington; 2012.
11. Wolf K, Tsakiris DA, Weber R, Erb P, Battegay M, Swiss HIV Cohort Study. Antiretroviral therapy reduces markers of endothelial and coagulation activation in patients infected with human immunodeficiency virus type 1. J Infect Dis 2002; 185:456-462.
12. Papasavvas E, Azzoni L, Pistilli M, Hancock A, Reynolds G, Gallo C, et al. Increased soluble vascular cell adhesion molecule-1 plasma levels and soluble intercellular adhesion molecule-1 during antiretroviral therapy interruption and retention of elevated soluble vascular cellular adhesion molecule- 1 levels following resumption of antiretroviral therapy. AIDS 2008; 22:1153-1161.
13. Sipsas NV, Sfikakis PP, Touloumi G, Pantazis N, Choremi H, Kordossis T. Elevated serum levels of soluble immune activation markers are associated with increased risk for death in HAART-naive HIV-1-infected patients. AIDS Patient Care STDS 2003; 17:147-153.
14. Martin HL Jr, Jackson DJ, Mandaliya K, Bwayo J, Rakwar JP, Nyange P, et al. Preparation for AIDS vaccine evaluation in Mombasa, Kenya: establishment of seronegative cohorts of commercial sex workers and trucking company employees. AIDS Res Hum Retroviruses 1994; 10 (Suppl 2):S235-237.
15. Lavreys L, Baeten JM, Kreiss JK, Richardson BA, Chohan BH, Hassan W, et al. Injectable contraceptive use and genital ulcer disease during the early phase of HIV-1 infection increase plasma virus load in women. J Infect Dis 2004; 189:303-311.
16. Emery S, Bodrug S, Richardson BA, Giachetti C, Bott MA, Panteleeff D, et al. Evaluation of performance of the Gen-Probe human immunodeficiency virus type 1 viral load assay using primary subtype A, C, and D isolates from Kenya. J Clin Microbiol 2000; 38:2688-2695.
17. Sagar M, Lavreys L, Baeten JM, Richardson BA, Mandaliya K, Chohan BH, et al. Infection with multiple human immunodeficiency virus type 1 variants is associated with faster disease progression. J Virol 2003; 77:12921-12926.
18. Lavreys L, Baeten JM, Chohan V, McClelland RS, Hassan WM, Richardson BA, et al. Higher set point plasma viral load and more-severe acute HIV type 1 (HIV-1) illness predict mortality among high-risk HIV-1-infected African women. Clin Infect Dis 2006; 42:1333-1339.
19. Ricciuto DR, dos Santos CC, Hawkes M, Toltl LJ, Conroy AL, Rajwans N, et al. Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis. Crit Care Med 2011; 39:702-710.
20. Page AV, Kotb M, McGeer A, Low DE, Kain KC, Liles WC. Systemic dysregulation of angiopoietin-1/2 in streptococcal toxic shock syndrome. Clin Infect Dis 2011; 52:e157-e161.
21. Durbin J. Incomplete blocks in ranking experiements. Br J Psychol 1951; 4:85-90.
22. Skillings JH, Mack GA. On the use of a Friedman-type statistic in balanced and unbalanced block designs. Technometrics 1981; 23:171-177.
23. Elices MJ, Osborn L, Takada Y, Crouse C, Luhowskyj S, Hemler ME, et al. VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/ fibronectin binding site. Cell 1990; 60:577-584.
24. Szmitko PE, Wang CH, Weisel RD, de Almeida JR, Anderson TJ, Verma S. New markers of inflammation and endothelial cell activation: Part I. Circulation 2003; 108:1917-1923.
25. Gearing AJ, Hemingway I, Pigott R, Hughes J, Rees AJ, Cashman SJ. Soluble forms of vascular adhesion molecules, E-selectin, ICAM-1, and VCAM-1: pathological significance. Ann N Y Acad Sci 1992; 667:324-331.
26. Blankenberg S, Barbaux S, Tiret L. Adhesion molecules and atherosclerosis. Atherosclerosis 2003; 170:191-203.
27. Nordoy I, Aukrust P, Muller F, Froland SS. Abnormal levels of circulating adhesion molecules in HIV-1 infection with characteristic alterations in opportunistic infections. Clin Immunol Immunopathol 1996; 81:16-21.
28. Francisci D, Giannini S, Baldelli F, Leone M, Belfiori B, Guglielmini G, et al. HIV type 1 infection, and not short-term HAART, induces endothelial dysfunction. AIDS 2009; 23:589-596.
29. Fourie C, van Rooyen J, Pieters M, Conradie K, Hoekstra T, Schutte A, et al. Is HIV-1 infection associated with endothelial dysfunction in a population of African ancestry in South Africa? Cardiovasc J Afr 2011; 22:134-140.
30. Melendez MM, McNurlan MA, Mynarcik DC, Khan S, Gelato MC. Endothelial adhesion molecules are associated with inflammation in subjects with HIV disease. Clin Infect Dis 2008; 46:775-780.
31. Liu K, Chi DS, Li C, Hall HK, Milhorn DM, Krishnaswamy G, et al. HIV-1 Tat protein-induced VCAM-1 expression in human pulmonary artery endothelial cells and its signaling. Am J Physiol Lung Cell Mol Physiol 2005; 289:L252-260.
32. Syed SS, Balluz RS, Kabagambe EK, Meyer WA 3rd, Lukas S, Wilson CM, et al. Assessment of biomarkers of cardiovascular risk among HIV-1-infected adolescents: role of soluble vascular cell adhesion molecule (sVCAM) as an early indicator of endothelial inflammation. AIDS Res Hum Retroviruses 2013; 29:493-500.
33. Blankenberg S, Rupprecht HJ, Bickel C, Peetz D, Hafner G, Tiret L, et al. Circulating cell adhesion molecules and death in patients with coronary artery disease. Circulation 2001; 104: 1336-1342.
34. Achhra AC, Amin J, Law MG, Grulich AE, Yeung J, Kelleher AD, et al. Changes in metabolic, inflammatory and coagulation biomarkers after HIV seroconversion: the Health in Men (HIM) Biomarker sub-study. Antivir Ther 2012; [Epub ahead of print].