Egr2-neurons control the adult respiratory response to hypercapnia

Brain Research

Volumn 1511, Issue , 2013, Pages 115-125

  Ray, Russell S ^a   Corcoran, Andrea E ^b   Brust, Rachael D ^a   Soriano, Laura P ^a   Nattie, Eugene E ^b   Dymecki, Susan M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

Egr2; Hypercapnic respiratory response; Pharmaco genetics

Indexed keywords

CARBON DIOXIDE; EARLY GROWTH RESPONSE FACTOR 2;

ADULT ANIMAL; ARTICLE; BODY TEMPERATURE; BREATHING RATE; CHEMORECEPTOR REFLEX; COMPENSATION; HYPERCAPNIA; LETHALITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATION CONTROL; SEROTONINERGIC NERVE CELL;

ACTION POTENTIALS; ANIMALS; BRAIN STEM; CARBON DIOXIDE; COLD TEMPERATURE; EARLY GROWTH RESPONSE PROTEIN 2; HYPERCAPNIA; MICE; NEURONS; RESPIRATION; THERMOGENESIS;

ANIMALIA; MUS;

EID: 84879841372     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2012.12.017     Document Type: Article

References (30)

1. S.B. Abbott, R.L. Stornetta, M.G. Fortuna, S.D. Depuy, G.H. West, T.E. Harris, and P.G. Guyenet Photostimulation of retrotrapezoid nucleus phox2b-expressing neurons in vivo produces long-lasting activation of breathing in rats J. Neurosci. 29 2009 5806 5819
2. M.R. Akilesh, M. Kamper, A. Li, and E.E. Nattie Effects of unilateral lesions of retrotrapezoid nucleus on breathing in awake rats J.Appl. Physiol. 82 1997 469 479
3. J. Amiel, V. Dubreuil, N. Ramanantsoa, G. Fortin, J. Gallego, J.F. Brunet, and C. Goridis PHOX2B in respiratory control: lessons from congenital central hypoventilation syndrome and its mouse models Respir. Physiol. Neurobiol. 168 2009 125 132
4. B.N. Armbruster, X. Li, M.H. Pausch, S. Herlitze, and B.L. Roth Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand Proc. Natl. Acad. Sci. USA 104 2007 5163 5168
5. G. Cano, A.M. Passerin, J.C. Schiltz, J.P. Card, S.F. Morrison, and A.F. Sved Anatomical substrates for the central control of sympathetic outflow to interscapular adipose tissue during cold exposure J. Comp. Neurol. 460 2003 303 326
6. J.L. Carroll Invited review: developmental plasticity in respiratory control J. Appl. Physiol. 94 2003 375 389
7. 2 chemoreceptors Respir. Physiol. 129 2001 219 229
8. V. Dubreuil, M. Thoby-Brisson, M. Rallu, K. Persson, A. Pattyn, C. Birchmeier, J.F. Brunet, G. Fortin, and C. Goridis Defective respiratory rhythmogenesis and loss of central chemosensitivity in Phox2b mutants targeting retrotrapezoid nucleus neurons J. Neurosci. 29 2009 14836 14846
9. J.L. Feldman, G.S. Mitchell, and E.E. Nattie Breathing: rhythmicity, plasticity, chemosensitivity Annu. Rev. Neurosci. 26 2003 239
10. S.M. Ferguson, D. Eskenazi, M. Ishikawa, M.J. Wanat, P.E. Phillips, Y. Dong, B.L. Roth, and J.F. Neumaier Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization Nat. Neurosci. 14 2011 22 24
11. C. Goridis, and J.F. Brunet Central chemoreception: lessons from mouse and human genetics Respir. Physiol. Neurobiol. 173 2010 312 321
12. P.G. Guyenet, R.L. Stornetta, and D.A. Bayliss Central respiratory chemoreception J. Comp. Neurol. 518 2010 3883 3906
13. T.D. Jacquin, V. Borday, S. Schneider-Maunoury, P. Topilko, G. Ghilini, F. Kato, P. Charnay, and J. Champagnat Reorganization of pontine rhythmogenic neuronal networks in Krox-20 knockout mice Neuron 17 1996 747 758
14. P. Jensen, A.F. Farago, R.B. Awatramani, M.M. Scott, E.S. Deneris, and S.M. Dymecki Redefining the serotonergic system by genetic lineage Nat. Neurosci. 11 2008 417 419
15. A. Li, L. Emond, and E. Nattie Brainstem catecholaminergic neurons modulate both respiratory and cardiovascular function Adv. Exp. Med. Biol. 605 2008 371 376
16. L. Madisen, T.A. Zwingman, S.M. Sunkin, S.W. Oh, H.A. Zariwala, H. Gu, L.L. Ng, R.D. Palmiter, M.J. Hawrylycz, and A.R. Jones A robust and high-throughput Cre reporting and characterization system for the whole mouse brain Nat. Neurosci. 13 2009 133 140
17. N. Marina, A.P. Abdala, S. Trapp, A. Li, E.E. Nattie, J. Hewinson, J.C. Smith, J.F. Paton, and A.V. Gourine Essential role of Phox2b-expressing ventrolateral brainstem neurons in the chemosensory control of inspiration and expiration J. Neurosci. 30 2010 12466 12473
18. S.F. Morrison, K. Nakamura, and C.J. Madden Central control of thermogenesis in mammals Exp. Physiol. 93 2008 773 797
19. D.K. Mulkey, and I.C. Wenker Astrocyte chemoreceptors: mechanisms of H+ sensing by astrocytes in the retrotrapezoid nucleus and their possible contribution to respiratory drive Exp. Physiol. 96 2011 400 406
20. E. Nattie, and A. Li Central chemoreception is a complex system function that involves multiple brain stem sites J. Appl. Physiol. 106 2009 1464 1466
21. E.E. Nattie Central chemosensitivity, sleep, and wakefulness Respir. Physiol. 129 2001 257 268
22. E.E. Nattie, H. Julius, and Jr. Comroe Distinguished lecture: central chemoreception: then... and now J. Appl. Physiol. 110 2011 1 8
23. 2 chemosensitivity in conditional Phox2b mutants J. Neurosci. 31 2011 12880 12888
24. R.S. Ray, A.E. Corcoran, R.D. Brust, J.C. Kim, G.B. Richerson, E. Nattie, and S.M. Dymecki Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition Science 333 2011 637 642
25. S. Schneider-Maunoury, P. Topilko, T. Seitandou, G. Levi, M. Cohen-Tannoudji, S. Pournin, C. Babinet, and P. Charnay Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain Cell 75 1993 1199 1214
26. S. Schneider-Maunoury, T. Seitanidou, P. Charnay, and A. Lumsden Segmental and neuronal architecture of the hindbrain of Krox-20 mouse mutants Development 124 1997 1215 1226
27. M. Thoby-Brisson, M. Karlen, N. Wu, P. Charnay, J. Champagnat, and G. Fortin Genetic identification of an embryonic parafacial oscillator coupling to the preBotzinger complex Nat. Neurosci. 12 2009 1028 1035
28. O. Voiculescu, P. Charnay, and S. Schneider-Maunoury Expression pattern of a Krox-20/Cre knock-in allele in the developing hindbrain, bones, and peripheral nervous system Genesis 26 2000 123 126
29. O. Voiculescu, E. Taillebourg, C. Pujades, C. Kress, S. Buart, P. Charnay, and S. Schneider-Maunoury Hindbrain patterning: Krox20 couples segmentation and specification of regional identity Development 128 2001 4967 4978
30. D.G. Wilkinson, S. Bhatt, P. Chavrier, R. Bravo, and P. Charnay Segment-specific expression of a zinc-finger gene in the developing nervous system of the mouse Nature 337 1989 461 464