Entecavir improves the outcome of acute-on-chronic liver failure due to the acute exacerbation of chronic hepatitis B

Hepatology International

Volumn 7, Issue 2, 2013, Pages 460-467

  Lin, Bingliang ^a   Pan, Calvin Q ^b   Xie, Dongying ^a   Xie, Junqiang ^a   Xie, Shibin ^a   Zhang, Xiaohong ^a   Wu, Biao ^c   Lin, Chaoshuang ^a   Gao, Zhiliang ^a  

^a THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c HAINAN PROVINCIAL PEOPLE S HOSPITAL   (China)

Author keywords

Acute on chronic liver failure (ACLF); Antiviral therapy; Entecavir; Hepatitis B; Predicting factor

Indexed keywords

ALBUMIN; BILIRUBIN; CHOLESTEROL; ENTECAVIR; VIRUS DNA;

ACUTE ON CHRONIC LIVER FAILURE; ADULT; AGED; ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE SEVERITY; DRUG EFFICACY; END STAGE LIVER DISEASE; FEMALE; HEPATITIS B; HUMAN; INTERNATIONAL NORMALIZED RATIO; MAJOR CLINICAL STUDY; MALE; OPEN STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTHROMBIN TIME; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE; SURVIVAL RATE; VIRUS REACTIVATION;

EID: 84879840891     PISSN: 19360533     EISSN: 19360541     Source Type: Journal    
DOI: 10.1007/s12072-012-9415-y     Document Type: Article

References (17)

1. Bosch FX, Ribes J, Cleries R, Diaz M. Epidemiology of hepatocellular carcinoma. Clin Liver Dis 2005;9(2):191-211, v
2. Lee WM, Squires RH Jr, Nyberg SL, Doo E, Hoofnagle JH. Acute liver failure: summary of a workshop. Hepatology 2008;47(4):1401-15
3. Liu Q, Liu Z, Wang T, et al. Characteristics of acute and sub-acute liver failure in China: nomination, classification, and interval. J Gastroenterol Hepatol 2007;22(12):2101-216
4. Sarin SK, Kumar A, Almeida JA, et al. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL). Hepatol Int 2009;3(1):269-82
5. Chuang CS, Tung SY, Lee IL, et al. Clinical features and outcome of chronic viral hepatitis with acute exacerbation in patients with concurrent infections of hepatitis B and C virus. Dig Dis Sci 2008;53(2):511-6
6. Wang YM, Tang YZ. Antiviral therapy for hepatitis B virus associated hepatic failure. Hepatobiliary Pancreat Dis Int 2009;8(1):17-24
7. Tsubota A, Arase Y, Suzuki Y, et al. Lamivudine monotherapy for spontaneous severe acute exacerbation of chronic hepatitis B. J Gastroenterol Hepatol 2005;20(3):426-32
8. Liaw YF, Sheen IS, Lee CM, et al. Tenofovir disoproxil fumarate (TDF), emtricitabine/TDF, and entecavir in patients with decompensated chronic hepatitis B liver disease. Hepatology 2011;53(1):62-72
9. Liaw YF, Sung JJ, Chow WC, et al. Lamivudine for patients with chronic hepatitis B and advanced liver disease. N Engl J Med 2004;351(15):1521-31
10. Chien RN, Lin CH, Liaw YF. The effect of lamivudine therapy in hepatic decompensation during acute exacerbation of chronic hepatitis B. J Hepatol 2003;38(3):322-7
11. Tillmann HL, Hadem J, Leifeld L, et al. Safety and efficacy of lamivudine in patients with severe acute or fulminant hepatitis B, a multicenter experience. J Viral Hepat 2006;13(4):256-63
12. Lu GF, Tang FA, Zheng PY, Yang PC, Qi YM. Entecavir up-regulates dendritic cell function in patients with chronic hepatitis B. World J Gastroenterol 2008;14(10):1617-21
13. Pan CQ, Tong M, Kowdley KV et al. High rates of viral suppression after long-term entecavir treatment of Asian patients with hepatitis B e antigen-positive chronic hepatitis B. Clin Gastroenterol Hepatol 2012;10(9):1047-1050, e1
14. Wong VW, Wong GL, Yiu KK, et al. Entecavir treatment in patients with severe acute exacerbation of chronic hepatitis B. J Hepatol 2011;54(2):236-42
15. Garg H, Sarin SK, Kumar M, et al. Tenofovir improves the outcome in patients with spontaneous reactivation of hepatitis B presenting as acute-on-chronic liver failure. Hepatology 2011;53(3):774-80
16. Chan HL, Chim AM, Lau JT, et al. Evaluation of model for end-stage liver disease for prediction of mortality in decompensated chronic hepatitis B. Am J Gastroenterol 2006;101(7):1516-23
17. Wong VW, Chim AM, Wong GL, Sung JJ, Chan HL. Performance of the new MELD-Na score in predicting 3-month and 1-year mortality in Chinese patients with chronic hepatitis B. Liver Transpl 2007;13(9):1228-35 Technology Projects Technology Projects