Nectin-2 and DDX3 are biomarkers for metastasis and poor prognosis of squamous cell/adenosquamous carcinomas and adenocarcinoma of gallbladder

International Journal of Clinical and Experimental Pathology

Volumn 6, Issue 2, 2013, Pages 179-190

  Miao, Xiongying ^a   Yang Dr , Zhu Lin ^a   Xiong, Li ^a   Zou, Qiong ^b   Yuan, Yuan ^b   Li, Jinghe ^c   Liang, Lufeng ^d   Chen, Meigui ^e   Chen, Senlin ^f  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c CENTRAL SOUTH UNIVERSITY   (China)

^d Hunan Provincial Second People s Hospital   (China)

^e Loudi Central Hospital   (China)

^f HUNAN CANCER HOSPITAL   (China)

Author keywords

Adenocarcinoma; Adenosquamous carcinoma; DDX3; Gallbladder cancer; Metastasis; Nectin 2; Prognosis; Squamous cell carcinoma

Indexed keywords

CELL ADHESION MOLECULE; DDX3X PROTEIN, HUMAN; DEAD BOX PROTEIN; NECTINS; TUMOR MARKER;

ADENOCARCINOMA; ADENOSQUAMOUS CARCINOMA; ADULT; AGED; ARTICLE; DDX3; FEMALE; GALLBLADDER CANCER; GALLBLADDER TUMOR; HUMAN; KAPLAN MEIER METHOD; LYMPH NODE METASTASIS; MALE; METABOLISM; METASTASIS; MIDDLE AGED; MORTALITY; MULTIVARIATE ANALYSIS; NECTIN-2; PATHOLOGY; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; RISK FACTOR; SQUAMOUS CELL CARCINOMA; VERY ELDERLY;

ADENOCARCINOMA; ADENOSQUAMOUS CARCINOMA; DDX3; GALLBLADDER CANCER; METASTASIS; NECTIN-2; PROGNOSIS; SQUAMOUS CELL CARCINOMA;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; CELL ADHESION MOLECULES; DEAD-BOX RNA HELICASES; FEMALE; GALLBLADDER NEOPLASMS; HUMANS; KAPLAN-MEIER ESTIMATE; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RISK FACTORS; TUMOR MARKERS, BIOLOGICAL;

MLCS; MLOWN;

EID: 84879829040     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ. Cancer statistics 2008. CA Cancer J Clin 2008; 58: 71-96.
2. Jayaraman S, Jarnagin WR. Management of gallbladder cancer. Gastroenterol Clin North Am 2010; 39: 331-342.
3. Reid KM, Ramos-De la Medina A, Donohue JH. Diagnosis and surgical management of gallbladder cancer: a review. J Gastrointest Surg 2007; 11: 671-81.
4. Hawkins WG, DeMatteo RP, Jarnagin WR, Ben-Porat L, Blumgart LH, Fong Y. Jaundice predicts advanced disease and early mortality in patients with gallbladder cancer. Ann Surg Oncol 2004; 11: 310-315.
5. Ootani T, Shirai Y, Tsukada K, Muto T. Relationship between gallbladder carcinoma and the segmental type of adenomyomatosis of the gallbladder. Cancer 1992; 69: 2647-52.
6. Roa JC, Tapia O, Cakir A, Basturk O, Dursun N, Akdemir D, Saka B, Losada H, Bagci P, Adsay NV. Squamous cell and adenosquamous carcinomas of the gallbladder: clinicopathological analysis of 34 cases identified in 606 carcinomas. Mod Pathol 2011; 24: 1069-78.
7. Park SB, Kim YH, Rho HL, Chae GB, Hong SK. Primary carcinosarcoma of the gallbladder. J Korean Surg Soc 2012; 82: 54-8.
8. Liu DC, Yang ZL. MTDH and EphA7 are markers for metastasis and poor prognosis of gallbladder adenocarcinoma. Diagn Cytopathol 2011 Sep 30. doi: 10.1002/dc.21821.
9. Iiizumi M, Liu W, Pai SK, Furuta E, Watabe K. Drug development against metastasis-related genes and their pathways: a rationale for cancer therapy. Biochim Biophys Acta 2008; 1786: 87-104.
10. Moh MC, Shen S. The roles of cell adhesion molecules in tumor suppression and cell migration: a new paradox. Cell Adh Migr 2009; 3: 334-6.
11. Chambers AF, Groom AC, MacDonald IC. Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2002; 2: 563-572.
12. Brown DM, Ruoslahti E. Metadherin, a cell surface protein in breast tumors that mediates lung metastasis. Cancer Cell 2004; 5: 365-374.
13. Miyoshi J, Takai Y. Nectin and nectin-like molecules: biology and pathology. Am J Nephrol 2007; 27: 590-604.
14. Takai Y, Miyoshi J, Ikeda W, Ogita H. Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation. Nat Rev Mol Cell Biol 2008; 9: 603-15.
15. Sakisaka T, Takai Y. Biology and pathology of nectins and nectin-like molecules. Curr Opin Cell Biol 2004; 16: 513-21.
16. Matsushima H, Utani A, Endo H, Matsuura H, Kakuta M, Nakamura Y, Matsuyoshi N, Matsui C, Nakanishi H, Takai Y, Shinkai H. The expression of nectin-1alpha in normal human skin and various skin tumours. Br J Dermatol 2003; 148: 755-62.
17. Guzman G, Oh S, Shukla D, Valyi-Nagy T. Nectin-1 expression in the normal and neoplastic human uterine cervix. Arch Pathol Lab Med 2006; 130: 1193-5.
18. Yu Z, Chan MK, O-charoenrat P, Eisenberg DP, Shah JP, Singh B, Fong Y, Wong RJ. Enhanced nectin-1 expression and herpes oncolytic sensitivity in highly migratory and invasive carcinoma. Clin Cancer Res 2005; 11: 4889-97.
19. Pende D, Spaggiari GM, Marcenaro S, Martini S, Rivera P, Capobianco A, Falco M, Lanino E, Pierri I, Zambello R, Bacigalupo A, Mingari MC, Moretta A, Moretta L. Analysis of the receptorligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112). Blood 2005; 105: 2066-73.
20. Sanchez-Correa B, Gayoso I, Bergua JM, Casado JG, Morgado S, Solana R, Tarazona R. Decreased expression of DNAM-1 on NK cells from acute myeloid leukemia patients. Immunol Cell Biol 2012; 90: 109-15.
21. El-Sherbiny YM, Meade JL, Holmes TD, McGonagle D, Mackie SL, Morgan AW, Cook G, Feyler S, Richards SJ, Davies FE, Morgan GJ, Cook GP. The requirement for DNAM-1, NKG2D, and NKp46 in the natural killer cell-mediated killing of myeloma cells. Cancer Res 2007; 67: 8444-9.
22. Botlagunta M, Krishnamachary B, Vesuna F, Winnard PT Jr, Bol GM, Patel AH, Raman V. Expression of DDX3 is directly modulated by hypoxia inducible factor-1 alpha in breast epithelial cells. PLoS One 2011; 6: e17563.
23. Botlagunta M, Vesuna F, Mironchik Y, Raman A, Lisok A, Winnard P Jr, Mukadam S, Van Diest P, Chen JH, Farabaugh P, Patel AH, Raman V. Oncogenic role of DDX3 in breast cancer biogenesis. Oncogene 2008; 27: 3912-22.
24. Schroder M. Human DEAD-box protein 3 has multiple functions in gene regulation and cell cycle control and is a prime target for viral manipulation. Biochem Pharmacol 2010; 79: 297-306.
25. Huang JS, Chao CC, Su TL, Yeh SH, Chen DS, Chen CT, Chen PJ, Jou YS. Diverse cellular transformation capability of overexpressed genes in human hepatocellular carcinoma. Biochem Biophys Res Commun 2004; 315: 950-958.
26. Sun M, Song L, Li Y, Zhou T, Jope RS. Identification of an antiapoptotic protein complex at death receptors. Cell Death Differ 2008; 15: 1887-900.
27. Chang PC, Chi CW, Chau GY, Li FY, Tsai YH, Wu JC, Wu Lee YH. DDX3, a DEAD box RNA helicase, is deregulated in hepatitis virus-associated hepatocellular carcinoma and is involved in cell growth control. Oncogene 2006; 25: 1991-2003.
28. Nishihara K, Nagai E, Izumi Y, Yamaguchi K, Tsuneyoshi M. Adenosquamous carcinoma of the gallbladder: a clinicopathological, immunohistochemical and flow-cytometric study of twenty cases. Jpn J Cancer Res 1994; 85: 389-399.
29. Kondo M, Dono K, Sakon M, Shimizu J, Nagano H, Nakamori S, Umeshita K, Wakasa K, Monden M. Adenosquamous carcinoma of the gallbladder. Hepatogastroenterology 2002; 49: 1230-1234.