Pivotal regulatory network and genes in osteosarcoma

Archives of Medical Science

Volumn 9, Issue 3, 2013, Pages 569-575

  Luo, Yi ^a   Deng, Zhansheng ^a   Chen, Jing ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Osteosarcoma; Pathway enrichment; Transcriptome network

Indexed keywords

BCL2 RELATED PROTEIN A1; CCAAT ENHANCER BINDING PROTEIN ALPHA; CCAAT ENHANCER BINDING PROTEIN BETA; INTERLEUKIN 6; PHOSPHATIDYLINOSITOL; PROTEIN P53; RETINOIC ACID RECEPTOR ALPHA; TRANSCRIPTION FACTOR;

ANTIGEN PRESENTATION; APOPTOSIS; ARTICLE; CANCER GENETICS; CANCER GROWTH; CELL PROLIFERATION; GENE EXPRESSION; GENE FUNCTION; GENE REGULATORY NETWORK; GENETIC REGULATION; GENETIC SCREENING; HUMAN; OSTEOSARCOMA; SIGNAL TRANSDUCTION;

EID: 84879818878     PISSN: 17341922     EISSN: None     Source Type: Journal    
DOI: 10.5114/aoms.2012.30956     Document Type: Article

References (42)

1. Ragland BD, Bell WC, Lopez RR, Siegal GP. Cytogenetics and molecular biology of osteosarcoma. Lab Invest 2002; 82: 365-73. (Pubitemid 34311110)
2. Clark JC, Dass CR, Choong PF. A review of clinical and molecular prognostic factors in osteosarcoma. J Cancer Res Clin Oncol 2008; 134: 281-97. (Pubitemid 351170066)
3. Ścibior-Bentkowska D, Skrzycki D, Podsiad M, Czeczot H. Changes of the glutathione enzymatic redox system in human gastrointestinal tract tumours. Arch Med Sci 2009; 5: 500-5.
4. Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996; 86: 353-64. (Pubitemid 26272076)
5. Broadhead ML, Clark JC, Myers DE, Dass CR, Choong PF. The molecular pathogenesis of osteosarcoma: a review. Sarcoma 2011; 2011: 959248.
6. Fuchs B, Pritchard DJ. Etiology of osteosarcoma. Clin Orthop Relat Res 2002; 397: 40.
7. Kansara M, Thomas DM. Molecular pathogenesis of osteosarcoma. DNA Cell Biol 2007; 26: 1-18. (Pubitemid 46219587)
8. Charity RM, Foukas AF, Deshmukh NS, Grimer RJ. Vascular endothelial growth factor expression in osteosarcoma. Clin Orthop Relat Res 2006; 448: 193-8. (Pubitemid 44324869)
9. Bjørnland K, Flatmark K, Pettersen S, Aaasen AO, Fodstad O, Maelandsmo GM. Matrix metalloproteinases participate in osteosarcoma invasion. J Surg Res 2005; 127: 151-6. (Pubitemid 41080627)
10. Wolf M, El-Rifai W, Tarkkanen M, et al. Novel findings in gene expression detected in human osteosarcoma by cDNA microarray. Cancer Genet Cytogenet 2000; 123: 128-32. (Pubitemid 32012494)
11. Squire JA, Pei J, Marrano P, et al. High-resolution mapping of amplifications and deletions in pediatric osteosarcoma by use of CGH analysis of cDNA microarrays. Genes Chromosomes Cancer 2003; 38: 215-25. (Pubitemid 37259638)
12. Trougakos IP, Chondrogianni N, Amarantos I, et al. Genome-wide transcriptome profile of the human osteosarcoma Sa OS and U-2 OS cell lines. Cancer Genet Cytogenet 2010; 196: 109-18.
13. Kubista B, Klinglmueller F, Bilban M, et al. Microarray analysis identifies distinct gene expression profiles associated with histological subtype in human osteosarcoma. Int Orthop 2011; 35: 401-11.
14. Kanehisa M. The KEGG database. Novartis Found Symp 2002; 247: 91-101.
15. Wingender E. The TRANSFAC project as an example of framework technology that supports the analysis of genomic regulation. Brief Bioinform 2008; 9: 326-32. (Pubitemid 351894493)
16. Jiang C, Xuan Z, Zhao F, Zhang MQ. TRED: a transcriptional regulatory element database, new entries and other development. Nucleic Acids Res 2007; 35 (Database issue): D137-40. (Pubitemid 46056185)
17. Smyth GK. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 2004; 3: Article3.
18. Shannon P, Markiel A, Ozier O, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 2003; 13: 2498-504. (Pubitemid 37428274)
19. Huang da W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009; 4: 44-57.
20. Draghici S, Khatri P, Tarca AL, et al. A systems biology approach for pathway level analysis. Genome Res 2007; 17: 1537-45. (Pubitemid 47529438)
21. Germain P, Chambon P, Eichele G, et al. International Union of Pharmacology. LX. Retinoic acid receptors. Pharmacol Rev 2006; 58: 712-25. (Pubitemid 44833741)
22. Shimizu T, Ishikawa T, Sugihara E, et al. c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis. Oncogene 2010; 29: 5687-99.
23. Scionti I, Michelacci F, Pasello M, et al. Clinical impact of the methotrexate resistance-associated genes C-MYC and dihydrofolate reductase (DHFR) in high-grade osteosarcoma. Ann Oncol 2008; 19: 1500-8.
24. Avnet S, Longhi A, Salerno M, et al. Increased osteoclast activity is associated with aggressiveness of osteosarcoma. Int J Oncol 2008; 33: 1231-8.
25. Margulies L, Sehgal PB. Modulation of the human interleukin-6 promoter (IL-6) and transcription factor C/EBP beta (NF-IL6) activity by p53 species. J Biol Chem 1993; 268: 15096-100. (Pubitemid 23206661)
26. Pakos EE, Kyzas PA, Ioannidis JP. Prognostic significance of TP53 tumor suppressor gene expression and mutations in human osteosarcoma: a meta-analysis. Clin Cancer Res 2004; 10: 6208-14. (Pubitemid 39287528)
27. Park HR, Jung WW, Bertoni F, et al. Molecular analysis of p53, MDM2 and H-ras genes in low-grade central osteosarcoma. Pathol Res Pract 2004; 200: 439-45. (Pubitemid 38937183)
28. Pérez-Casellas LA, Wang X, Howard KD, Rehage MW, Strong DD, Linkhart TA. Nuclear factor I transcription factors regulate IGF binding protein 5 gene transcription in human osteoblasts. Biochim Biophys Acta 2009; 1789: 78-87.
29. Xu X, Zhao Y, Simon R. Gene set expression comparison kit for BRB-array tools. Bioinformatics 2008; 24: 137-9.
30. Galien R, Garcia T. Estrogen receptor impairs interleukin-6 expression by preventing protein binding on the NF-kappaB site. Nucleic Acids Res 1997; 25: 2424-9. (Pubitemid 27303703)
31. Campbell KJ, Witty JM, Rocha S, Perkins ND. Cisplatin mimics ARF tumor suppressor regulation of RelA (p65) nuclear factor-kappaB transactivation. Cancer Res 2006; 66: 929-35. (Pubitemid 43165960)
32. Wagner ER, He BC, Chen L, et al. Therapeutic implications of PPAR-alpha in human osteosarcoma. PPAR Res 2010; 2010: 956427.
33. He BC, Chen L, Zuo GW, et al. Synergistic antitumor effect of the activated PPARgamma and retinoid receptors on human osteosarcoma. Clin Cancer Res 2010; 16: 2235-45.
34. Gutierrez S, Javed A, Tennant DK, et al. CCAAT/enhancer-binding proteins (C/EBP) beta and delta activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone-specific expression. J Biol Chem 2002; 277: 1316-23. (Pubitemid 34968885)
35. Smink JJ, Leutz A. Rapamycin and the transcription factor C/EBPbeta as a switch in osteoclast differentiation: implications for lytic bone diseases. J Mol Med 2010; 88: 227-33.
36. Wang ZX, Yang JS, Pan X, et al. Functional and biological analysis of Bcl-xL expression in human osteosarcoma. Bone 2010; 47: 445-54.
37. Lee TL, Yeh J, Friedman J, et al. A signal network involving coactivated NF-kappaB and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas. Int J Cancer 2008; 122: 1987-98. (Pubitemid 351441187)
38. Marinari B, Costanzo A, Marzano V, Piccolella E, Tuosto L. CD28 delivers a unique signal leading to the selective recruitment of RelA and p52 NF-kappaB subunits on IL-8 and Bcl-xL gene promoters. Proc Natl Acad Sci U S A 2004; 101: 6098-103. (Pubitemid 38520534)
39. Díaz-Montero CM, Wygant JN, McIntyre BW. PI3-K/Akt-mediated anoikis resistance of human osteosarcoma cells requires Src activation. Eur J Cancer 2006; 42: 1491-500. (Pubitemid 43903158)
40. Liu B, Shi ZL, Feng J, Tao HM. Celecoxib, a cyclooxygenase-2 inhibitor, induces apoptosis in human osteosarcoma cell line MG-63 via down-regulation of PI3K/Akt. Cell Biol Int 2008; 32: 494-501.
41. Sosa-García B, Gunduz V, Vázquez-Rivera V, et al. A role for the retinoblastoma protein as a regulator of mouse osteoblast cell adhesion: implications for osteogenesis and osteosarcoma formation. PLoS One 2010; 5: e13954.
42. Endo-Munoz L, Cumming A, Sommerville S, Dickinson I, Saunders NA. Osteosarcoma is characterised by reduced expression of markers of osteoclastogenesis and antigen presentation compared with normal bone. Br J Cancer 2010; 103: 73-81.