Enpp1: A Potential Facilitator of Breast Cancer Bone Metastasis

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Lau, Wen Min ^a   Doucet, Michele ^a   Stadel, Ryan ^a   Huang, David ^a   Weber, Kristy L ^a   Kominsky, Scott L ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOTAXIN; COMPLEMENTARY DNA; ENPP1 PROTEIN; PHOSPHODIESTERASE; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE METASTASIS; BREAST CANCER; BREAST TUMOR; CONTROLLED STUDY; DIGITAL RADIOGRAPHY; DNA MICROARRAY; FEMALE; GENE EXPRESSION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MOUSE; NONHUMAN; NUDE RAT; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; BONE NEOPLASMS; BREAST NEOPLASMS; CELL LINE, TUMOR; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION; HUMANS; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; PHOSPHORIC DIESTER HYDROLASES; PYROPHOSPHATASES;

ANIMALIA; MURINAE; MUS MUSCULUS;

EID: 84879805481     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066752     Document Type: Article

References (17)

1. Huang R, Rosenbach M, Vaughn R, Provvedini D, Rebbe N, et al. (1994) Expression of the murine plasma cell nucleotide pyrophosphohydrolase PC-1 is shared by human liver, bone, and cartilage cells. Regulation of PC-1 expression in osteosarcoma cells by transforming growth factor-beta. The Journal of clinical investigation 94: 560-567.
2. Rodriguez C, Causse A, Ursule E, Theillet C, (2000) At least five regions of imbalance on 6q in breast tumors, combining losses and gains. Genes, chromosomes & cancer 27: 76-84.
3. Marchio C, Iravani M, Natrajan R, Lambros MB, Savage K, et al. (2008) Genomic and immunophenotypical characterization of pure micropapillary carcinomas of the breast. The Journal of pathology 215: 398-410.
4. Rutsch F, Ruf N, Vaingankar S, Toliat MR, Suk A, et al. (2003) Mutations in ENPP1 are associated with 'idiopathic' infantile arterial calcification. Nature genetics 34: 379-381.
5. Rutsch F, Vaingankar S, Johnson K, Goldfine I, Maddux B, et al. (2001) PC-1 nucleoside triphosphate pyrophosphohydrolase deficiency in idiopathic infantile arterial calcification. The American journal of pathology 158: 543-554.
6. Saito T, Shimizu Y, Hori M, Taguchi M, Igarashi T, et al. (2011) A patient with hypophosphatemic rickets and ossification of posterior longitudinal ligament caused by a novel homozygous mutation in ENPP1 gene. Bone 49: 913-916.
7. Goldfine ID, Maddux BA, Youngren JF, Reaven G, Accili D, et al. (2008) The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities. Endocrine reviews 29: 62-75.
8. Fleisch H, Russell RG, Straumann F, (1966) Effect of pyrophosphate on hydroxyapatite and its implications in calcium homeostasis. Nature 212: 901-903.
9. Meyer JL, Nancollas GH, (1973) The influence of multidentate organic phosphonates on the crystal growth of hydroxyapatite. Calcified tissue research 13: 295-303.
10. Clemens TL, Karsenty G, (2011) The osteoblast: an insulin target cell controlling glucose homeostasis. Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research 26: 677-680.
11. Belleannee C, Da Silva N, Shum WW, Brown D, Breton S, (2010) Role of purinergic signaling pathways in V-ATPase recruitment to apical membrane of acidifying epididymal clear cells. American journal of physiology Cell physiology 298: C817-830.
12. Lau WM, Weber KL, Doucet M, Chou YT, Brady K, et al. (2010) Identification of prospective factors promoting osteotropism in breast cancer: a potential role for CITED2. International journal of cancer Journal international du cancer 126: 876-884.
13. Harmey D, Hessle L, Narisawa S, Johnson KA, Terkeltaub R, et al. (2004) Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders. The American journal of pathology 164: 1199-1209.
14. Fedde KN, Blair L, Silverstein J, Coburn SP, Ryan LM, et al. (1999) Alkaline phosphatase knock-out mice recapitulate the metabolic and skeletal defects of infantile hypophosphatasia. Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research 14: 2015-2026.
15. Russell RG, Bisaz S, Donath A, Morgan DB, Fleisch H, (1971) Inorganic pyrophosphate in plasma in normal persons and in patients with hypophosphatasia, osteogenesis imperfecta, and other disorders of bone. The Journal of clinical investigation 50: 961-969.
16. Addison WN, Azari F, Sorensen ES, Kaartinen MT, McKee MD, (2007) Pyrophosphate inhibits mineralization of osteoblast cultures by binding to mineral, up-regulating osteopontin, and inhibiting alkaline phosphatase activity. The Journal of biological chemistry 282: 15872-15883.
17. Chirgwin JM, Guise TA, (2000) Molecular mechanisms of tumor-bone interactions in osteolytic metastases. Critical reviews in eukaryotic gene expression 10: 159-178.