Oral Exposure to Phytomonas serpens Attenuates Thrombocytopenia and Leukopenia during Acute Infection with Trypanosoma cruzi

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  da Silva, Rosiane V ^a   Malvezi, Aparecida D ^a   da Augusto, Leonardo Silva ^c   Kian, Danielle ^a   Tatakihara, Vera Lúcia H ^a   Yamauchi, Lucy M ^a   Yamada Ogatta, Sueli F ^a   Rizzo, Luiz V ^b   Schenkman, Sergio ^c   Pinge Filho, Phileno ^a  

^a STATE UNIVERSITY OF LONDRINA   (Brazil)

^b HOSPITAL ISRAELITA ALBERT EINSTEIN   (Brazil)

^c FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

HYPERIMMUNE GLOBULIN; PHYTOMONAS SERPENS VACCINE; SIALIDASE; TRANS SIALIDASE; UNCLASSIFIED DRUG; VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHAGAS DISEASE; CONTROLLED STUDY; FEMALE; LEUKOPENIA; MALE; MORTALITY; MOUSE; NONHUMAN; PARASITE LOAD; PARASITEMIA; PHYTOMONAS; PHYTOMONAS SERPENS; THROMBOCYTE COUNT; THROMBOCYTOPENIA; TRYPOMASTIGOTE;

ACUTE DISEASE; ANIMALS; BLOOD PLATELETS; CHAGAS DISEASE; FEMALE; GLYCOPROTEINS; HOST-PARASITE INTERACTIONS; IMMUNIZATION; LEUKOPENIA; LYCOPERSICON ESCULENTUM; MALE; MICE; MICE, INBRED C57BL; N-ACETYLNEURAMINIC ACID; NEURAMINIDASE; PLATELET COUNT; THROMBOCYTOPENIA; TRYPANOSOMA CRUZI; TRYPANOSOMATINA;

MUS; PHYTOMASTIGOPHOREA; PHYTOMONAS SERPENS; TRYPANOSOMA CRUZI;

EID: 84879773376     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0068299     Document Type: Article

References (48)

1. McGhee RB, Cosgrove WB, (1980) Biology and physiology of the lower Trypanosomatidae. Microbiological Reviews 44: 140-173.
2. Vickerman K, (1994) The evolutionary expansion of the trypanosomatid flagellates. International Journal for Parasitology 24: 1317-1331.
3. Stuart K, Brun R, Croft S, Fairlamb A, Gurtler RE, et al. (2008) Kinetoplastids: related protozoan pathogens, different diseases. The Journal of Clinical Investigation 118: 1301-1310.
4. Moncayo A, Ortiz Yanine MI, (2006) An update on Chagas disease (human American trypanosomiasis). Annals of Tropical Medicine and Parasitology 100: 663-677.
5. Toso A, Vial F, Galanti N, (2011) Oral transmission of Chagas' disease. Revista Medica de Chile 139: 258-266.
6. Shikanai-Yasuda MA, Carvalho NB, (2012) Oral Transmission of Chagas Disease. Clinical Infectious Diseases 54: 845-852.
7. Py M, (2011) Neurologic Manifestations of Chagas Disease. Current Neurology and Neuroscience Reports 11: 536-542.
8. Rassi A Jr, Rassi A, Marin-Neto JA, (2010) Chagas disease. Lancet 375: 1388-1402.
9. Junqueira C, Caetano B, Bartholomeu DC, Melo MB, Ropert C, et al. (2010) The endless race between Trypanosoma cruzi and host immunity: lessons for and beyond Chagas disease. Expert Reviews in Molecular Medicine 12: e29.
10. Cardoso JE, Brener Z, (1980) Hematological changes in mice experimentally infected with Trypanosoma cruzi. Memorias do Instituto Oswaldo Cruz 75: 97-104.
11. Repka D, Rangel HA, Atta AM, Gavino VA, Piedrabuena AE, (1985) Experimental Chagas' disease in mice infected with one LD50 of parasite. Revista Brasileira de Biologia 45: 309-316.
12. Marcondes MC, Borelli P, Yoshida N, Russo M, (2000) Acute Trypanosoma cruzi infection is associated with anemia, thrombocytopenia, leukopenia, and bone marrow hypoplasia: reversal by nifurtimox treatment. Microbes and Infection 2: 347-352.
13. Ikede BO, Lule M, Terry RJ, (1977) Anaemia in trypanosomiasis: mechanisms of erythrocyte destruction in mice infected with Trypanosoma congolense or T. brucei. Acta Tropica 34: 53-60.
14. Claster S, (2002) Biology of anemia, differential diagnosis, and treatment options in human immunodeficiency virus infection. The Journal of Infectious Diseases 185Suppl 2: S105-109.
15. Paul RE, Brey PT, (2003) Malaria parasites and red blood cells: from anaemia to transmission. Molecules and Cells 15: 139-149.
16. Malvezi AD, Cecchini R, de Souza F, Tadokoro CE, Rizzo LV, et al. (2004) Involvement of nitric oxide (NO) and TNF-alpha in the oxidative stress associated with anemia in experimental Trypanosoma cruzi infection. FEMS Immunology and Medical Microbiology 41: 69-77.
17. Santiago HC, Feng CG, Bafica A, Roffe E, Arantes RM, et al. (2005) Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth. Journal of Immunology 175: 8165-8172.
18. Giorgi ME, Ratier L, Agusti R, Frasch AC, de Lederkremer RM, (2010) Synthesis of PEGylated lactose analogs for inhibition studies on T. cruzi trans-sialidase. Glycoconjugate Journal 27: 549-559.
19. Schauer R, Kamerling JP, (2011) The Chemistry and Biology of Trypanosomal trans-Sialidases: Virulence Factors in Chagas Disease and Sleeping Sickness. Chembiochem: European Journal of Chemical Biology 2246: 2246-2764.
20. Dc-Rubin SS, Schenkman S, (2012) Trypanosoma cruzi trans-sialidase as a multifunctional enzyme in Chagas' disease. Cellular Microbiology 14: 1522-1530.
21. Tribulatti MV, Mucci J, Van Rooijen N, Leguizamon MS, Campetella O, (2005) The trans-sialidase from Trypanosoma cruzi induces thrombocytopenia during acute Chagas' disease by reducing the platelet sialic acid contents. Infection and Immunity 73: 201-207.
22. Goncalves CC, Reiche EM, De Abreu Filho BA, Silveira TG, Felizardo TC, et al. (2002) Evaluation of antigens from various Leishmania species in a Western blot for diagnosis of American tegumentary leishmaniasis. The American Journal of Tropical Medicine and Hygiene 66: 91-102.
23. Lopes JD, Caulada Z, Barbieri CL, Camargo EP, (1981) Cross-reactivity between Trypanosoma cruzi and insect trypanosomatids as a basis for the diagnosis of Chagas' disease. The American Journal of Tropical Medicine and Hygiene 30: 1183-1188.
24. Bregano JW, Picao RC, Graca VK, Menolli RA, Itow Jankevicius S, et al. (2003) Phytomonas serpens, a tomato parasite, shares antigens with Trypanosoma cruzi that are recognized by human sera and induce protective immunity in mice. FEMS Immunology and Medical Microbiology 39: 257-264.
25. Medina-Acosta E, Franco AMR, Jansen AM, Sampol M, Nev's N, et al. (1994) Trans-sialidase and sialidase activities discriminate between morphologically indistinguishable trypanosomatids. European Journal of Biochemistry 225: 333-339.
26. Graca-de Souza VK, Monteiro-Goes V, Manque P, Souza TA, Correa PR, et al. (2010) Sera of chagasic patients react with antigens from the tomato parasite Phytomonas serpens. Biological Research 43: 233-241.
27. Pinge-Filho P, Peron JP, de Moura TR, Menolli RA, Graca VK, et al. (2005) Protective immunity against Trypanosoma cruzi provided by oral immunization with Phytomonas serpens: role of nitric oxide. Immunology Letters 96: 283-290.
28. Dollet M, (1984) Plant-Diseases Caused by Flagellate Protozoa (Phytomonas). Annual Review of Phytopathology 22: 115-132.
29. Camargo EP, Kastelein P, Roitman I, (1990) Trypanosomatid Parasites of Plants (Phytomonas). Parasitology Today 6: 22-25.
30. Camargo EP, (1999) Phytomonas and other trypanosomatid parasites of plants and fruit. Advances in Parasitology 42: 29-112.
31. Jankevicius JV, Jankevicius SI, Campaner M, Conchon I, Maeda LA, et al. (1989) Life-Cycle and Culturing of Phytomonas-serpens (Gibbs), a Trypanosomatid Parasite of Tomatoes. Journal of Protozoology 36: 265-271.
32. Silva LHP, Nussenzweig V, (1953) Sobre uma cepa de Trypanosoma cruzi altamente virulenta para o camundongo branco. Folia Clinica Biologica 20: 191-203.
33. Dacie JV, Lewis SM (1995) Practical haematology: Churchill Livingstone.
34. Hideko Tatakihara VL, Cecchini R, Borges CL, Malvezi AD, Graca-de Souza VK, et al. (2008) Effects of cyclooxygenase inhibitors on parasite burden, anemia and oxidative stress in murine Trypanosoma cruzi infection. FEMS Immunology and Medical Microbiology 52: 47-58.
35. Schenkman S, Chaves LB, Pontes de Carvalho L, Eichinger D, (1994) A proteolytic fragment of Trypanosoma cruzi trans-sialidase lacking the carboxy-terminal domain is active, monomeric and generates antibodies that inhibit enzymatic activity. Journal of Biological Chemistry 269: 7970-7975.
36. Schenkman S, Pontes de Carvalho L, Nussenzweig V, (1992) Trypanosoma cruzi trans-sialidase and neuraminidase activities can be mediated by the same enzymes. The Journal of Experimental Medicine 175: 567-575.
37. Estevam M, Appoloni CR, Malvezi AD, Tatakihara VL, Panis C, et al. (2012) Trypanosoma cruzi: in vivo evaluation of iron in skin employing X-ray fluorescence (XRF) in mouse strains that differ in their susceptibility to infection. FEMS Immunology and Medical Microbiology 64: 334-342.
38. Frasch AC, (2000) Functional diversity in the trans-sialidase and mucin families in Trypanosoma cruzi. Parasitology Today 16: 282-286.
39. de Titto EH, Araujo FG, (1988) Serum neuraminidase activity and hematological alterations in acute human Chagas' diseases. Clinical Immunology and Immunopathology 46: 157-161.
40. Leguizamon MS, Campetella O, Russomando G, Almiron M, Guillen I, et al. (1994) Antibodies inhibiting Trypanosoma cruzi trans-sialidase activity in sera from human infections. Journal of Infectious Diseases 170: 1570-1574.
41. Pereira-Chioccola VL, Schenkman S, Kloetzel J, (1994) Sera from chronic Chagasic patients and animals infected with Trypanosoma cruzi inhibit trans-sialidase by recognizing its catalytic domain. Infection and Immunity 62: 2973-2978.
42. Buscaglia CA, Alfonso J, Campetella O, Frasch AC, (1999) Tandem amino acid repeats rrom Trypanosoma cruzi shed antigens increase the half-life of proteins in blood. Blood 93: 2025-2032.
43. Souza Mdo C, Reis AP, Da Silva WD, Brener Z, (1974) Mechanism of acquired immunity induced by "Leptomonas pessoai" against Trypanosoma cruzi in mice. The Journal of Protozoology 21: 579-584.
44. Csete M, Lev BI, Pereira ME, (1985) An influenza virus model for Trypanosoma cruzi infection: interactive roles for neuraminidase and lectin. Current Topics in Microbiology and Immunology 117: 153-165.
45. de Souza Tde A, Graca-de Souza VK, Lancheros CA, Monteiro-Goes V, Krieger MA, et al. (2011) Identification, molecular and functional characterization of calmodulin gene of Phytomonas serpens 15 T that shares high similarity with its pathogenic counterparts Trypanosoma cruzi. The Protein Journal 30: 212-219.
46. Briones MR, Egima CM, Eichinger D, Schenkan S, (1995) Trans-sialidase genes expressed in mammalian forms of Trypanosoma cruzi evolved from ancestor genes expressed in insect forms of the parasite. Journal of Molecular Evolution 41: 120-131.
47. Gazzinelli RT, Romanha AJ, Fontes G, Chiari E, Gazzinelli G, et al. (1991) Distribution of carbohydrates recognized by the lectins Euonymus europaeus and concanavalin A in monoxenic and heteroxenic trypanosomatids. The Journal of Protozoology 38: 320-325.
48. Marques AF, Nohara L, Ganiko L, Silva LS, Travassos LR, et al. (2010) Alpha-Gal-Based Vaccine Provides Full Protection Against Trypanosoma cruzi Infection in Mice. Glycobiology 20: 1528-1528.