Deterioration of gait and balance over time: The effects of age-related white matter change - The LADIS study

Cerebrovascular Diseases

Volumn 35, Issue 6, 2013, Pages 544-553

  Kreisel, Stefan H ^a   Blahak, Christian ^a   Bäzner, Hansjörg ^b   Inzitari, Domenico ^c   Pantoni, Leonardo ^c   Poggesi, Anna ^c   Chabriat, Hugues ^d   Erkinjuntti, Timo ^e   Fazekas, Franz ^f   Ferro, José M ^g   Langhorne, Peter ^h   O'Brien, John ⁱ   Scheltens, Philip ^j   Visser, Marieke C ^j   Wahlund, Lars Olof ^k   Waldemar, Gunhild ^l   Wallin, Anders ^m   Hennerici, Michael G ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b KLINIKUM STUTTGART   (Germany)

^c UNIVERSITY OF FLORENCE   (Italy)

^d HÔPITAL LARIBOISIÈRE   (France)

^e HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^f MEDICAL UNIVERSITY OF GRAZ   (Austria)

^g Centro de Estudos Egas Moniz   (Portugal)

^h GLASGOW ROYAL INFIRMARY   (United Kingdom)

ⁱ NEWCASTLE UNIVERSITY   (United Kingdom)

^j VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^k KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^l Mental Health Services CPH   (Denmark)

^m UNIVERSITY OF GOTHENBURG   (Sweden)

more..

Author keywords

Aging; Cerebral small vessel disease; Epidemiology; Gait; Postural balance

Indexed keywords

AGE; AGE RELATED WHITE MATTER CHANGE; AGED; ARTICLE; BALANCE DISORDER; BODY EQUILIBRIUM; CROSS-SECTIONAL STUDY; DETERIORATION; DISEASE SEVERITY; FAZEKAS SCALE; FEMALE; FOLLOW UP; GAIT; GAIT DISORDER; HUMAN; MAJOR CLINICAL STUDY; MALE; MOTOR DYSFUNCTION; MOTOR DYSFUNCTION ASSESSMENT; MOTOR PERFORMANCE; MULTICENTER STUDY; NEUROIMAGING; PATIENT CARE; PRIORITY JOURNAL; PROPENSITY SCORE; PROSPECTIVE STUDY; RATING SCALE; SHORT PHYSICAL PERFORMANCE BATTERY; WHITE MATTER LESION;

AGE FACTORS; AGED; AGED, 80 AND OVER; BRAIN; CROSS-SECTIONAL STUDIES; DISABILITY EVALUATION; DISABLED PERSONS; FEMALE; FOLLOW-UP STUDIES; GAIT; HUMANS; MALE; MIDDLE AGED; RISK FACTORS; SEVERITY OF ILLNESS INDEX; TIME FACTORS;

EID: 84879767046     PISSN: 10159770     EISSN: 14219786     Source Type: Journal    
DOI: 10.1159/000350725     Document Type: Article

References (25)

1. Soumare A, Elbaz A, Zhu Y, Maillard P, Crivello F, Tavernier B, Dufouil C, Mazoyer B, Tzourio C: White matter lesions volume and motor performances in the elderly. Ann Neurol 2009; 65: 706-715.
2. Rosano C, Kuller LH, Chung H, Arnold AM, Longstreth WT, Newman AB: Subclinical brain magnetic resonance imaging abnormalities predict physical functional decline in high-functioning older adults. J Am Geriatr Soc 2005; 53: 649-654.
3. de Leeuw FE, de Groot JC, Achten E, Oudkerk M, Ramos LM, Heijboer R, Hofman A, Jolles J, van Gijn J, Breteler MM: Prevalence of cerebral white matter lesions in elderly people: A population-based magnetic resonance imaging study. The Rotterdam Scan Study. J Neurol Neurosurg Psychiatry 2001; 70: 9-14.
4. Pantoni L, Garcia JH: The significance of cerebral white matter abnormalities 100 years after Binswanger's report. A review. Stroke 1995; 26: 1293-1301.
5. Wahlund LO, Barkhof F, Fazekas F, Bronge L, Augustin M, Sjogren M, Wallin A, Ader H, Leys D, Pantoni L, Pasquier F, Erkinjuntti T, Scheltens P: A new rating scale for age-related white matter changes applicable to MRI and CT. Stroke 2001; 32: 1318-1322.
6. Zheng JJ, Delbaere K, Close JC, Sachdev PS, Lord SR: Impact of white matter lesions on physical functioning and fall risk in older people: A systematic review. Stroke 2011; 42: 2086-2090.
7. Silbert LC, Nelson C, Howieson DB, Moore MM, Kaye JA: Impact of white matter hyperintensity volume progression on rate of cognitive and motor decline. Neurology 2008; 71: 108-113.
8. LADIS Study Group: 2001-2011: A decade of the LADIS (Leukoaraiosis and Disability) study: what have we learned about white matter changes and small-vessel disease? Cerebrovasc Dis 2011; 32: 577-588.
9. Pantoni L, Basile AM, Pracucci G, Asplund K, Bogousslavsky J, Chabriat H, Erkinjuntti T, Fazekas F, Ferro JM, Hennerici M, O'Brien J, Scheltens P, Visser MC, Wahlund L-O, Waldemar G, Wallin A, Inzitari D: Impact of agerelated cerebral white matter changes on the transition to disability-the LADIS study: rationale, design and methodology. Neuroepidemiology 2005; 24: 51-62.
10. Baezner H, Blahak C, Poggesi A, Pantoni L, Inzitari D, Chabriat H, Erkinjuntti T, Fazekas F, Ferro JM, Langhorne P, O'Brien J, Scheltens P, Visser MC, Wahlund LO, Waldemar G, Wallin A, Hennerici MG: Association of gait and balance disorders with age-related white matter changes: The LADIS study. Neurology 2008; 70: 935-942.
11. Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG, Scherr PA, Wallace RB: A short physical performance battery assessing lower extremity function: Association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol 1994; 49:M85-M94.
12. Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA: MRI signal abnormalities at 1. 5 T in Alzheimer's dementia and normal aging. AJNR Am J Neuroradiol 1987; 8: 421-426.
13. Rubin DB, Thomas N: Matching using estimated propensity scores: relating theory to practice. Biometrics 1996; 52: 249-262.
14. Rosenbaum PR, Rubin DB: The central role of the propensity score in observational studies for causal effects. Biometrika 1983; 70: 41-55.
15. Inzitari D, Pracucci G, Poggesi A, Carlucci G, Barkhof F, Chabriat H, Erkinjuntti T, Fazekas F, Ferro JM, Hennerici M, Langhorne P, O'Brien J, Scheltens P, Visser MC, Wahlund LO, Waldemar G, Wallin A, Pantoni L, on behalf of the LSG: Changes in white matter as determinant of global functional decline in older independent outpatients: Three year follow-up of LADIS (Leukoaraiosis and Disability) study cohort. BMJ 2009; 339:b2477.
16. Sauerbrei W, Royston P: Building multivariable prognostic and diagnostic models: Transformations of the predictors by using fractional polynomials. J R Stat Soc A 1999; 162: 71-94.
17. Barnett AG, van der Pols JC, Dobson AJ: Regression to the mean: what it is and how to deal with it. Int J Epidemiol 2005; 34: 215-220.
18. van Straaten ECW, Fazekas F, Rostrup E, Scheltens P, Schmidt R, Pantoni L, Inzitari D, Waldemar G, Erkinjuntti T, Mantyla R, Wahlund L-O, Barkhof F: Impact of white matter hyperintensities scoring method on correlations with clinical data: The LADIS study. Stroke 2006; 37: 836-840.
19. de Laat KF, Tuladhar AM, van Norden AGW, Norris DG, Zwiers MP, de Leeuw F-E: Loss of white matter integrity is associated with gait disorders in cerebral small vessel disease. Brain 2011; 134: 73-83.
20. Srikanth V, Phan TG, Chen J, Beare R, Stapleton JM, Reutens DC: The location of white matter lesions and gait-A voxel-based study. Ann Neurol 2010; 67: 265-269.
21. Blahak C, Baezner H, Pantoni L, Poggesi A, Chabriat H, Erkinjuntti T, Fazekas F, Ferro JM, Langhorne P, O'Brien J, Visser MC, Wahlund LO, Waldemar G, Wallin A, Inzitari D, Hennerici MG, on behalf of the LSG: Deep frontal and periventricular age related white matter changes but not basal ganglia and infratentorial hyperintensities are associated with falls: cross sectional results from the LADIS study. J Neurol Neurosurg Psychiatry 2009; 80: 608-613.
22. Gill TM, Allore HG, Hardy SE, Guo Z: The dynamic nature of mobility disability in older persons. J Am Geriatr Soc 2006; 54: 248-254.
23. Chong RKY, Chastan N, Welter M-L, Do M-C: Age-related changes in the center of mass velocity control during walking. Neurosci Lett 2009; 458: 23-27.
24. Melzer I, Oddsson LIE: The effect of a cognitive task on voluntary step execution in healthy elderly and young individuals. J Am Geriatr Soc 2004; 52: 1255-1262.
25. Shumway-Cook A, Guralnik JM, Phillips CL, Coppin AK, Ciol MA, Bandinelli S, Ferrucci L: Age-associated declines in complex walking task performance: The Walking InCHIANTI toolkit. J Am Geriatr Soc 2007; 55: 58-65.