IL12-Mediated Liver Inflammation Reduces the Formation of AAV Transcriptionally Active Forms but Has No Effect over Preexisting AAV Transgene Expression

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Gil Fariña, Irene ^a   Di Scala, Marianna ^a   Vanrell, Lucia ^a   Olagüe, Cristina ^a   Vales, Africa ^a   High, Katherine A ^b   Prieto, Jesus ^a,c   Mingozzi, Federico ^b   Gonzalez Aseguinolaza, Gloria ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c UNIVERSITY CLINIC OF NAVARRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; AZACITIDINE; DEXAMETHASONE; DNA; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 1BETA; LUCIFERASE; PARVOVIRUS VECTOR; TRICHOSTATIN A; TUMOR NECROSIS FACTOR ALPHA;

ADENO ASSOCIATED VIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIARRHEA; DNA METHYLATION; DOWN REGULATION; DRUG DOSE COMPARISON; FEMALE; GENE EXPRESSION; GENETIC TRANSDUCTION; HEPATITIS; LIVER CELL; LOW DRUG DOSE; MORTALITY; MOUSE; NATURAL KILLER CELL; NONHUMAN; PROTEIN EXPRESSION; T LYMPHOCYTE; TRANSGENE; VIRAL GENE DELIVERY SYSTEM; VIRUS CAPSID; VIRUS GENOME; WEIGHT REDUCTION;

ANIMALS; CAPSID; DEPENDOVIRUS; FEMALE; GENE EXPRESSION; GENETIC THERAPY; GENETIC VECTORS; HEPATOCYTES; INFLAMMATION; INTERFERON-GAMMA; INTERLEUKIN-12; KILLER CELLS, NATURAL; LIVER; MICE; MICE, INBRED C57BL; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES; TRANSCRIPTION, GENETIC; TRANSGENES;

ANIMALIA; MIRIDAE; MUS;

EID: 84879760446     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067748     Document Type: Article

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