Time-dependent degradation pattern of cardiac troponin T following myocardial infarction

Clinical Chemistry

Volumn 59, Issue 7, 2013, Pages 1083-1090

  Cardinaels, Eline P M ^a   Mingels, Alma M A ^a   Van Rooij, Tom ^a   Collinson, Paul O ^b   Prinzen, Frits W ^c   Van Dieijen Visser, Marja P ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ST GEORGE S HOSPITAL   (United Kingdom)

^c MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

TROPONIN T;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GEL FILTRATION CHROMATOGRAPHY; HEART INFARCTION; HOSPITAL ADMISSION; HUMAN; IMMUNOASSAY; MALE; PROTEIN ANALYSIS; PROTEIN DEGRADATION; WESTERN BLOTTING;

BIOLOGICAL MARKERS; BLOTTING, WESTERN; CHROMATOGRAPHY, GEL; HUMANS; MYOCARDIAL INFARCTION; TIME FACTORS; TROPONIN T;

EID: 84879717002     PISSN: 00099147     EISSN: 15308561     Source Type: Journal    
DOI: 10.1373/clinchem.2012.200543     Document Type: Article

References (34)

1. Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD, et al. Third universal definition of myocardial infarction. Circulation 2012;60:1581-98.
2. IFCC. Troponin assay analytical characteristics 2012. http://www.ifcc.org/ifcc-scientific-division/documents-of-the-sd/ troponinassayanalyticalchar acteristics2012/ (Accessed June 2013).
3. Collinson PO, van Dieijen-Visser MP, Pulkki K, Hammerer-Lercher A, Suvisaari J, Ravkilde J, et al. Evidence-based laboratory medicine: how well do laboratories follow recommendations and guidelines? The Cardiac Marker Guideline Uptake in Europe (CARMAGUE) study. Clin Chem 2012;58: 305-6.
4. Katus HA, Remppis A, Scheffold T, Diederich KW, Kuebler W. Intracellular compartmentation of cardiac troponin T and its release kinetics in patients with reperfused and nonreperfused myocardial infarction. Am J Cardiol 1991;67:1360-7.
5. Bleier J, Vorderwinkler KP, Falkensammer J, Mair P, Dapunt O, Puschendorf B, Mair J. Different intracellular compartmentations of cardiac troponins and myosin heavy chains: a causal connection to their different early release after myocardial damage. Clin Chem 1998;44:1912-8. (Pubitemid 28405755)
6. Jeong EM, Wang X, Xu K, Hossain MM, Jin JP. Nonmyofilament-associated troponin T fragments induce apoptosis. Am J Physiol Heart Circ Physiol 2009;297:H283-92.
7. Wu AH, Feng YJ, Moore R, Apple FS, McPherson PH, Buechler KF, Bodor G. Characterization of cardiac troponin subunit release into serum after acute myocardial infarction and comparison of assays for troponin T and I. American Association for Clinical Chemistry Subcommittee on cTnI Standardization. Clin Chem 1998;44:1198-208. (Pubitemid 28283057)
8. Labugger R, Organ L, Collier C, Atar D, Van Eyk JE. Extensive troponin I and T modification detected in serum from patients with acute myocardial infarction. Circulation 2000;102:1221-6.
9. McDonough JL, Arrell DK, Van Eyk JE. Troponin I degradation and covalent complex formation accompanies myocardial ischemia/reperfusion injury. Circ Res 1999;84:9-20. (Pubitemid 29074876)
10. Madsen LH, Christensen G, Lund T, Serebruany VL, Granger CB, Hoen I, et al. Time course of degradation of cardiac troponin I in patients with acute ST-elevation myocardial infarction. The ASSENT-2 troponin substudy. Circ Res 2006;99: 1141-7. (Pubitemid 44729939)
11. Katrukha AG, Bereznikova AV, Filatov VL, Esakova TV, Kolosova OV, Pettersson K, et al. Degradation of cardiac troponin I: implication for reliable immunodetection. Clin Chem 1998;44:2433-40. (Pubitemid 28565654)
12. Narolska NA, Piroddi N, Belus A, Boontje NM, Scellini B, Deppermann S, et al. Impaired diastolic function after exchange of endogenous troponin I with C-terminal truncated troponin I in human cardiac muscle. Circ Res 2006;99:1012-20. (Pubitemid 44657805)
13. Galinska A, Hatch V, Craig R, Murphy AM, Van Eyk JE, Wang CL, et al. The C terminus of cardiac troponin I stabilizes the Ca2+-activated state of tropomyosin on actin filaments. Circ Res 2010; 106:705-11.
14. Diris JH, Hackeng CM, Kooman JP, Pinto YM, Hermens WT, Van Dieijen-Visser MP. Impaired renal clearance explains elevated troponin T fragments in hemodialysis patients. Circulation 2004; 109:23-5. (Pubitemid 38056015)
15. Michielsen EC, Diris JH, Kleijnen VW, Wodzig WK, Van Dieijen-Visser MP. Investigation of release and degradation of cardiac troponin T in patients with acute myocardial infarction. Clin Biochem 2007;40:851-5. (Pubitemid 47077407)
16. Bates KJ, Hall EM, Fahie-Wilson MN, Kindler H, Bailey C, Lythall D, Lamb EJ. Circulating immunoreactive cardiac troponin forms determined by gel filtration chromatography after acute myocardial infarction. Clin Chem 2010;56:952-8.
17. Fahie-Wilson MN, Carmichael DJ, Delaney MP, Stevens PE, Hall EM, Lamb EJ. Cardiac troponin T circulates in the free, intact form in patients with kidney failure. Clin Chem 2006;52:414-20.
18. Michielsen EC, Diris JH, Kleijnen VWVC, Wodzig WK, van Dieijen-Visser MP. Size-exclusion chromatography of circulating cardiac troponin T. Clin Chem 2006;52:2306-7. (Pubitemid 44925011)
19. Michielsen EC, Diris JH, Kleijnen VWVC, Wodzig WK, Van Dieijen-Visser MP. Interpretation of cardiac troponin T behaviour in size-exclusion chromatography. Clin Chem Lab Med 2006;44:1422-7. (Pubitemid 44967690)
20. Katrukha AG, Bereznikova AV, Esakova TV, Pettersson K, Lovgren T, Severina ME, et al. Troponin I is released in bloodstream of patients with acute myocardial infarction not in free form but as complex. Clin Chem 1997;43:1379-85. (Pubitemid 27329785)
21. Hamm CW, Ravkilde J, Gerhardt W, Jorgensen P, Peheim E, Ljungdahl L, et al. The prognostic value of serum troponin T in unstable angina. N Engl J Med 1992;327:146-50.
22. Latini R, Masson S, Anand IS, Missov E, Carlson M, Vago T, et al. Prognostic value of very low plasma concentrations of troponin T in patients with stable chronic heart failure. Circulation 2007;116:1242-9. (Pubitemid 47517535)
23. Stubbs P, Collinson P, Moseley D, Greenwood T, Noble M. Prognostic significance of admission troponin T concentrations in patients with myocardial infarction. Circulation 1996;94:1291-7. (Pubitemid 26307255)
24. Giannitsis E, Steen H, Kurz K, Ivandic B, Simon AC, Futterer S, et al. Cardiac magnetic resonance imaging study for quantification of infarct size comparing directly serial versus single time-point measurements of cardiac troponin T. J Am Coll Cardiol 2008;51:307-14.
25. Steen H, Giannitsis E, Futterer S, Merten C, Juenger C, Katus HA. Cardiac troponin T at 96 hours after acute myocardial infarction correlates with infarct size and cardiac function. J Am Coll Cardiol 2006;48:2192-4. (Pubitemid 44855412)
26. Giannitsis E, Kurz K, Hallermayer K, Jarausch J, Jaffe AS, Katus HA. Analytical validation of a high-sensitivity cardiac troponin T assay. Clin Chem 2010;56:254-61.
27. Cobbaert CM, Weykamp CW, Michielsen EC, Baadenhuijsen H, van Dieijen-Visser MP. Time-dependent instability of cardiac troponins in human plasma spiked with NIST reference material 2921. Clin Chem 2008;54:2078 -9.
28. Mingels A, Cobbaert C, Smit N, Van den Hof W, Van Dieijen-Visser M. Time- and temperature-dependent stability of NIST standard reference material 2921 in serum and plasma. Clin Chem Lab Med 2012;50:1681-4.
29. Ke L, Qi XY, Dijkhuis AJ, Chartier D, Nattel S, Henning RH, et al. Calpain mediates cardiac troponin degradation and contractile dysfunction in atrial fibrillation. J Mol Cell Cardiol 2008;45:685-93.
30. Feng HZ, Biesiadecki BJ, Yu ZB, Hossain MM, Jin JP. Restricted N-terminal truncation of cardiac troponin T: a novel mechanism for functional adaptation to energetic crisis. J Physiol 2008;283:33384-93.
31. Zhang Z, Biesiadecki BJ, Jin JP. Selective deletion of the NH2-terminal variable region of cardiac troponin T in ischemia reperfusion by myofibril-associated mu-calpain cleavage. Biochemistry 2006;45:11681-94. (Pubitemid 44454016)
32. Communal C, Sumandea M, de Tombe P, Narula J, Solaro RJ, Hajjar RJ. Functional consequences of caspase activation in cardiac myocytes. Proc Natl Acad Sci U S A 2002;99:6252-6. (Pubitemid 34493298)
33. Mingels A, Jacobs L, Michielsen E, Swaanenburg J, Wodzig W, van Dieijen-Visser M. Reference population and marathon runner sera assessed by highly sensitive cardiac troponin T and commercial cardiac troponin T and I assays. Clin Chem 2009;55:101-8.
34. Middleton N, George K, Whyte G, Gaze D, Collinson P, Shave R. Cardiac troponin T release is stimulated by endurance exercise in healthy humans. J Am Coll Cardiol 2008;52:1813-4.