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Volumn 14, Issue 8, 2013, Pages 676-677

Has targeted therapy for melanoma made chemotherapy obsolete?

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE INHIBITOR; DACARBAZINE; MITOGEN ACTIVATED PROTEIN KINASE; SELUMETINIB; TEMOZOLOMIDE; TRAMETINIB;

EID: 84879700284     PISSN: 14702045     EISSN: 14745488     Source Type: Journal    
DOI: 10.1016/S1470-2045(13)70298-5     Document Type: Letter
Times cited : (3)

References (10)
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  • 2
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    • Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial
    • Hauschild A, Grob JJ, Demidov LV, et al. Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet 2012, 380:358-365.
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    • Hauschild, A.1    Grob, J.J.2    Demidov, L.V.3
  • 3
    • 84875235432 scopus 로고    scopus 로고
    • MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study
    • Ascierto PA, Schadendorf DA, Berking C, et al. MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study. Lancet Oncol 2013, 14:249-256.
    • (2013) Lancet Oncol , vol.14 , pp. 249-256
    • Ascierto, P.A.1    Schadendorf, D.A.2    Berking, C.3
  • 4
    • 84863673204 scopus 로고    scopus 로고
    • Improved survival with MEK inhibition in BRAF-mutated melanoma
    • Flaherty KT, Robert C, Hersey P, et al. Improved survival with MEK inhibition in BRAF-mutated melanoma. N Engl J Med 2012, 367:107-114.
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  • 5
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    • Selumetinib plus dacarbazine versus placebo plus dacarbazine as first-line treatment for BRAF-mutant metastatic melanoma: a phase 2 double-blind randomised study
    • Robert C, Dummer R, Gutzmer R, et al. Selumetinib plus dacarbazine versus placebo plus dacarbazine as first-line treatment for BRAF-mutant metastatic melanoma: a phase 2 double-blind randomised study. Lancet Oncol 2013, 14:733-740.
    • (2013) Lancet Oncol , vol.14 , pp. 733-740
    • Robert, C.1    Dummer, R.2    Gutzmer, R.3
  • 6
    • 84877092892 scopus 로고    scopus 로고
    • Phase II trial of MEK inhibitor selumetinib (AZD6244, ARRY-142886) in patients with BRAFV600E/K-mutated melanoma
    • Catalanotti F, Solit DB, Pulitzer MP, et al. Phase II trial of MEK inhibitor selumetinib (AZD6244, ARRY-142886) in patients with BRAFV600E/K-mutated melanoma. Clin Cancer Res 2013, 19:2257-2264.
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  • 7
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    • Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations
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  • 8
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    • Phase II study of the MEK1/MEK2 inhibitor trametinib in patients with metastatic BRAF-mutant cutaneous melanoma previously treated with or without a BRAF inhibitor
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    • abstr 9003.
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.