-
1
-
-
0008390266
-
The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
-
DOI 10.1073/pnas.95.1.322
-
de Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE, et al. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci USA. 1998;95:322-7. (Pubitemid 28103952)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.1
, pp. 322-327
-
-
De Lecea, L.1
Kilduff, T.S.2
Peyron, C.3
Gao, X.-B.4
Foye, P.E.5
Danielson, P.E.6
Fukuhara, C.7
Battenberg, E.L.F.8
Gautvik, V.T.9
Bartlett II, F.S.10
Frankel, W.N.11
Van Den Pol, A.N.12
Bloom, F.E.13
Gautvik, K.M.14
Sutcliffe, J.G.15
-
2
-
-
20244380014
-
Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
-
DOI 10.1016/S0092-8674(00)80949-6
-
Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998;92:573-85. (Pubitemid 28101119)
-
(1998)
Cell
, vol.92
, Issue.4
, pp. 573-585
-
-
Sakurai, T.1
Amemiya, A.2
Ishii, M.3
Matsuzaki, I.4
Chemelli, R.M.5
Tanaka, H.6
Williams, S.C.7
Richardson, J.A.8
Kozlowski, G.P.9
Wilson, S.10
Arch, J.R.S.11
Buckingham, R.E.12
Haynes, A.C.13
Carr, S.A.14
Annan, R.S.15
McNulty, D.E.16
Liu, W.-S.17
Terrett, J.A.18
Elshourbagy, N.A.19
Bergsma, D.J.20
Yanagisawa, M.21
more..
-
3
-
-
79955810852
-
Hypocretin and its emerging role as a target for treatment of sleep disorders
-
21170610 10.1007/s11910-010-0172-9 1:CAS:528:DC%2BC3MXisFyksLY%3D
-
Cao M, Guilleminault C. Hypocretin and its emerging role as a target for treatment of sleep disorders. Curr Neurol Neurosci Rep. 2011;11:227-34.
-
(2011)
Curr Neurol Neurosci Rep
, vol.11
, pp. 227-234
-
-
Cao, M.1
Guilleminault, C.2
-
4
-
-
77951959293
-
Central chemoreception in wakefulness and sleep: Evidence for a distributed network and a role for orexin
-
20133433 10.1152/japplphysiol.01261.2009 1:CAS:528:DC%2BC3cXntFGisr8%3D
-
Nattie E, Li A. Central chemoreception in wakefulness and sleep: evidence for a distributed network and a role for orexin. J Appl Physiol. 2010;108:1417-24.
-
(2010)
J Appl Physiol
, vol.108
, pp. 1417-1424
-
-
Nattie, E.1
Li, A.2
-
5
-
-
67649448978
-
Orexin/hypocretin: A neuropeptide at the interface of sleep, energy homeostasis, and reward system
-
19549926 10.1124/pr.109.001321 1:CAS:528:DC%2BC3cXhsVWmu7jP
-
Tsujino N, Sakurai T. Orexin/hypocretin: a neuropeptide at the interface of sleep, energy homeostasis, and reward system. Pharmacol Rev. 2009;61:162-76.
-
(2009)
Pharmacol Rev
, vol.61
, pp. 162-176
-
-
Tsujino, N.1
Sakurai, T.2
-
6
-
-
79951994324
-
Orexin receptors: Pharmacology and therapeutic opportunities
-
21034217 10.1146/annurev-pharmtox-010510-100528 1:CAS:528: DC%2BC3MXisFOju74%3D
-
Scammell TE, Winrow CJ. Orexin receptors: pharmacology and therapeutic opportunities. Annu Rev Pharmacol Toxicol. 2011;51:243-66.
-
(2011)
Annu Rev Pharmacol Toxicol
, vol.51
, pp. 243-266
-
-
Scammell, T.E.1
Winrow, C.J.2
-
7
-
-
77649157819
-
Orexin receptor antagonists: A review of promising compounds patented since 2006
-
20180618 10.1517/13543770903567085 1:CAS:528:DC%2BC3cXisValurw%3D
-
Coleman PJ, Renger JJ. Orexin receptor antagonists: a review of promising compounds patented since 2006. Expert Opin Ther Pat. 2010;20:307-24.
-
(2010)
Expert Opin Ther Pat
, vol.20
, pp. 307-324
-
-
Coleman, P.J.1
Renger, J.J.2
-
8
-
-
33846979755
-
Promotion of sleep by targeting the orexin system in rats, dogs and humans
-
17259994 10.1038/nm1544 1:CAS:528:DC%2BD2sXhsVykurw%3D
-
Brisbare-Roch C, Dingemanse J, Koberstein R, Hoever P, Aissaoui H, Flores S, et al. Promotion of sleep by targeting the orexin system in rats, dogs and humans. Nat Med. 2007;13:150-5.
-
(2007)
Nat Med
, vol.13
, pp. 150-155
-
-
Brisbare-Roch, C.1
Dingemanse, J.2
Koberstein, R.3
Hoever, P.4
Aissaoui, H.5
Flores, S.6
-
9
-
-
77951497654
-
Orexin receptor antagonism, a new sleep-promoting paradigm: An ascending single-dose study with almorexant
-
20376002 10.1038/clpt.2010.19 1:CAS:528:DC%2BC3cXkvFCntLk%3D
-
Hoever P, de Haas S, Winkler J, Schoemaker RC, Chiossi E, van Gerven J, Dingemanse J. Orexin receptor antagonism, a new sleep-promoting paradigm: an ascending single-dose study with almorexant. Clin Pharmacol Ther. 2010;87:593-600.
-
(2010)
Clin Pharmacol Ther
, vol.87
, pp. 593-600
-
-
Hoever, P.1
De Haas, S.2
Winkler, J.3
Schoemaker, R.C.4
Chiossi, E.5
Van Gerven, J.6
Dingemanse, J.7
-
10
-
-
84861342704
-
Orexin receptor antagonism, a new sleep-enabling paradigm: A proof-of-concept clinical trial
-
22549286 10.1038/clpt.2011.370 1:CAS:528:DC%2BC38XnsFGnsLY%3D
-
Hoever P, Dorffner G, Beneš H, Penzel T, Danker-Hopfe H, Barbanoj MJ, et al. Orexin receptor antagonism, a new sleep-enabling paradigm: A proof-of-concept clinical trial. Clin Pharmacol Ther. 2012;91:975-85.
-
(2012)
Clin Pharmacol Ther
, vol.91
, pp. 975-985
-
-
Hoever, P.1
Dorffner, G.2
Beneš, H.3
Penzel, T.4
Danker-Hopfe, H.5
Barbanoj, M.J.6
-
11
-
-
84864144743
-
Orexin receptor antagonism: An ascending multiple-dose study with almorexant
-
22695489 10.1177/0269881112448946
-
Hoever P, de Haas SL, Dorffner G, Chiossi E, van Gerven JM, Dingemanse J. Orexin receptor antagonism: an ascending multiple-dose study with almorexant. J Psychopharmacol. 2012;26:1071-80.
-
(2012)
J Psychopharmacol
, vol.26
, pp. 1071-1080
-
-
Hoever, P.1
De Haas, S.L.2
Dorffner, G.3
Chiossi, E.4
Van Gerven, J.M.5
Dingemanse, J.6
-
12
-
-
84856455874
-
Absolute oral bioavailability of almorexant, a dual orexin receptor antagonist, in healthy human subjects
-
22302127 10.1159/000335367 1:CAS:528:DC%2BC38Xkt1CrtLs%3D
-
Hoch M, Hoever P, Zisowsky J, Priestley A, Fleet D, Dingemanse J. Absolute oral bioavailability of almorexant, a dual orexin receptor antagonist, in healthy human subjects. Pharmacology. 2012;89:53-7.
-
(2012)
Pharmacology
, vol.89
, pp. 53-57
-
-
Hoch, M.1
Hoever, P.2
Zisowsky, J.3
Priestley, A.4
Fleet, D.5
Dingemanse, J.6
-
13
-
-
10744232330
-
The conduct of in vitro and in vivo drug-drug interaction studies: A Pharmaceutical Research and Manufacturers of America (PhRMA) perspective
-
DOI 10.1124/dmd.31.7.815
-
Bjornsson TD, Callaghan JT, Einolf HJ, Fischer V, Gan L, Grimm S, Pharmaceutical Research and Manufacturers of America (PhRMA) Drug Metabolism/Clinical Pharmacology Technical Working Group; FDA Center for Drug Evaluation and Research (CDER), et al. The conduct of in vitro and in vivo drug-drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspective. Drug Metab Dispos. 2003;31:815-32. (Pubitemid 36759050)
-
(2003)
Drug Metabolism and Disposition
, vol.31
, Issue.7
, pp. 815-832
-
-
Bjornsson, T.D.1
Callaghan, J.T.2
Einolf, H.J.3
Fischer, V.4
Gan, L.5
Grimm, S.6
Kao, J.7
King, S.P.8
Miwa, G.9
Ni, L.10
Kumar, G.11
McLeod, J.12
Obach, R.S.13
Roberts, S.14
Roe, A.15
Shah, A.16
Snikeris, F.17
Sullivan, J.T.18
Tweedie, D.19
Vega, J.M.20
Walsh, J.21
Wrighton, S.A.22
more..
-
14
-
-
84877129431
-
Pharmacokinetic interactions of almorexant with midazolam and simvastatin, two CYP3A4 model substrates, in healthy male subjects
-
22990330 10.1007/s00228-012-1403-6 1:CAS:528:DC%2BC3sXis1Oisrc%3D
-
Hoch M, Hoever P, Alessi F, Theodor R, Dingemanse J. Pharmacokinetic interactions of almorexant with midazolam and simvastatin, two CYP3A4 model substrates, in healthy male subjects. Eur J Clin Pharmacol. 2013;69:523-32.
-
(2013)
Eur J Clin Pharmacol
, vol.69
, pp. 523-532
-
-
Hoch, M.1
Hoever, P.2
Alessi, F.3
Theodor, R.4
Dingemanse, J.5
-
15
-
-
0022997648
-
Clinical pharmacokinetics and pharmacodynamics of warfarin. Understanding the dose-effect relationship
-
Holford NH. Clinical pharmacokinetics and pharmacodynamics of warfarin. Understanding the dose-effect relationship. Clin Pharmacokinet. 1986;11:483-504. (Pubitemid 17203070)
-
(1986)
Clinical Pharmacokinetics
, vol.11
, Issue.6
, pp. 483-504
-
-
Holford, N.H.G.1
-
16
-
-
0031015345
-
Human P450 metabolism of warfarin
-
DOI 10.1016/S0163-7258(96)00140-4, PII S0163725896001404
-
Kaminsky LS, Zhang ZY. Human P450 metabolism of warfarin. Pharmacol Ther. 1997;73:67-74. (Pubitemid 26425815)
-
(1997)
Pharmacology and Therapeutics
, vol.73
, Issue.1
, pp. 67-74
-
-
Kaminsky, L.S.1
Zhang, Z.-Y.2
-
18
-
-
49449094988
-
Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects
-
18516070 10.1038/bjp.2008.210 1:CAS:528:DC%2BD1cXps1Gru7s%3D
-
Mohammed Abdul MI, Jiang X, Williams KM, Day RO, Roufogalis BD, Liauw WS, et al. Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects. Br J Pharmacol. 2008;154:1691-700.
-
(2008)
Br J Pharmacol
, vol.154
, pp. 1691-1700
-
-
Mohammed Abdul, M.I.1
Jiang, X.2
Williams, K.M.3
Day, R.O.4
Roufogalis, B.D.5
Liauw, W.S.6
-
19
-
-
33646920045
-
Effects of lasofoxifene on the pharmacokinetics and pharmacodynamics of single-dose warfarin
-
DOI 10.1111/j.1365-2125.2006.02589.x
-
Ouellet D, Bramson C, Carvajal-Gonzalez S, Roman D, Randinitis E, Remmers A, et al. Effects of lasofoxifene on the pharmacokinetics and pharmacodynamics of single-dose warfarin. Br J Clin Pharmacol. 2006;61:741-5. (Pubitemid 43794804)
-
(2006)
British Journal of Clinical Pharmacology
, vol.61
, Issue.6
, pp. 741-745
-
-
Ouellet, D.1
Bramson, C.2
Carvajal-Gonzalez, S.3
Roman, D.4
Randinitis, E.5
Remmers, A.6
Gardner, M.J.7
-
20
-
-
84879707490
-
Drug interaction studies - study design, data analysis, implications for dosing and labeling recommendations
-
U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Biologics Evaluation and Research (CBER)
-
Draft Guidance for Industry. Drug interaction studies - study design, data analysis, implications for dosing and labeling recommendations. U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Biologics Evaluation and Research (CBER); 2012.
-
(2012)
Draft Guidance for Industry
-
-
-
21
-
-
79960173507
-
Effects of fesoterodine on the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers
-
21496065 10.1111/j.1365-2125.2011.03989.x 1:CAS:528:DC%2BC3MXhtV2qtrrJ
-
Malhotra B, Alvey C, Gong J, Li X, Duczynski G, Gandelman K. Effects of fesoterodine on the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers. Br J Clin Pharmacol. 2011;72:257-62.
-
(2011)
Br J Clin Pharmacol
, vol.72
, pp. 257-262
-
-
Malhotra, B.1
Alvey, C.2
Gong, J.3
Li, X.4
Duczynski, G.5
Gandelman, K.6
-
22
-
-
84878018779
-
Almorexant effects on CYP3A4 activity studied by its simultaneous and time-separated administration with simvastatin and atorvastatin
-
23334403 10.1007/s00228-012-1470-8 1:CAS:528:DC%2BC3sXnslemu7s%3D
-
Hoch M, Hoever P, Theodor R, Dingemanse J. Almorexant effects on CYP3A4 activity studied by its simultaneous and time-separated administration with simvastatin and atorvastatin. Eur J Clin Pharmacol. 2013;69:1235-45.
-
(2013)
Eur J Clin Pharmacol
, vol.69
, pp. 1235-1245
-
-
Hoch, M.1
Hoever, P.2
Theodor, R.3
Dingemanse, J.4
|