Risk of complications after a peptic ulcer diagnosis: Effectiveness of proton pump inhibitors

Digestive Diseases and Sciences

Volumn 58, Issue 6, 2013, Pages 1653-1662

  Hernández Díaz, Sonia ^a   Martín Merino, Elisa ^b   García Rodríguez, Luis A ^b  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b Department of Pharmacoepidemiology   (Spain)

Author keywords

Gastrointestinal complications; Gastroprotection; Non steroidal anti inflammatory drugs; Peptic ulcer; Proton pump inhibitors

Indexed keywords

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; CORTICOSTEROID; HISTAMINE H2 RECEPTOR ANTAGONIST; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PROTON PUMP INHIBITOR;

ADULT; AGE; AGED; ALCOHOL CONSUMPTION; ANEMIA; ARTICLE; BODY MASS; CARDIOVASCULAR DISEASE; CLINICAL EFFECTIVENESS; COMPARATIVE STUDY; CONFIDENCE INTERVAL; CONTROLLED STUDY; DIGESTIVE SYSTEM PERFORATION; DISEASE DURATION; FEMALE; FOLLOW UP; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; OSTEOARTHRITIS; PEPTIC ULCER; POPULATION BASED CASE CONTROL STUDY; PRESCRIPTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RHEUMATOID ARTHRITIS; RISK; SEX; SMOKING; UPPER GASTROINTESTINAL BLEEDING;

ADULT; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; DUODENAL ULCER; FEMALE; FOLLOW-UP STUDIES; HUMANS; INCIDENCE; INTENTION TO TREAT ANALYSIS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; PEPTIC ULCER HEMORRHAGE; PEPTIC ULCER PERFORATION; PROTON PUMP INHIBITORS; RISK; STOMACH ULCER; TREATMENT OUTCOME;

EID: 84879691268     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-013-2561-9     Document Type: Article

References (26)

1. Hernández-Díaz S, García Rodríguez L. Incidence of serious upper gastrointestinal bleeding/perforation in the general population: review of epidemiologic studies. J Clin Epidemiol. 2002;55:157-163.
2. García Rodríguez L, Cattaruzzi C, Troncon MG, Agostinis L. Risk of hospitalization for upper gastrointestinal tract bleeding associated with ketorolac, other nonsteroidal anti-inflammatory drugs, calcium antagonists, and other antihypertensive drugs. Arch Intern Med. 1998;158:33-39.
3. Hernández-Díaz S, García-Rodríguez L. Overview of epidemiological studies published in the nineties on the association between non-steroidal anti-inflammatory drugs and upper gastrointestinal bleed/perforation. Arch Intern Med. 2000;160:2093-2099.
4. Hawkey C, Jeffrey A, Szczepnski L, et al. A comparison of omeprazole and misoprostol for treating and preventing ulcers associated with non-steroidal anti-inflammatory drugs. N Engl J Med. 1998;338:727-734.
5. Yeomans N, Tulassay Z, Juhasz L, et al. A comparison of omeprazole and ranitidine for treating and preventing ulcers associated with non-steroidal anti-inflammatory drugs. N Engl J Med. 1998;338:719-726.
6. Silverstein F, Graham D, Senior J, et al. Misoprostol reduces serious gastrointestinal complication in patients with rheumatoid arthritis receiving non-steroidal anti-inflammatory drugs. Ann Intern Med. 1995;123:241-249.
7. García-Rodríguez L, Hernández-Díaz S. Relative risk of upper gastrointestinal complications among users of acetaminophen and nonsteroidal anti-inflammatory drugs. Epidemiology. 2001;12:570-576.
8. Jensen D, Cheng S, Kovacs T, et al. A controlled study of ranitidine for the prevention of recurrent hemorrhage from duodenal ulcer. N Engl J Med. 1994;330:382-386.
9. Lai K, Lam S, Chu K, et al. Lansoprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin use. N Engl J Med. 2002;346:2033-2038.
10. García Rodríguez L, Ruigómez A. Secondary prevention of upper gastrointestinal bleeding associated with maintenance acid-suppressing treatment in patients with peptic ulcer bleed. Epidemiology. 1999;10:228-232.
11. Walker AM. Observation and inference. An introduction to the methods of epidemiology. Newton Lower Falls: Epidemiology Resources Inc.; 1991.
12. Ray WA. Evaluating medication effects outside of clinical trials: new-user designs. Am J Epidemiol. 2003;158:915-920.
13. Hernán M, Brumback B, Robins J. Marginal structural models to estimate the joint effect of non randomized treatments. J Am Stat Assoc. 2001;96:440-448.
14. Hernán M, Robins J. Instrumental variables for causal inference: an epidemiologist dream? Epidemiology. 2006;17:360-372.
15. Hernan MA, Hernandez-Diaz S. Beyond the intention-to-treat in comparative effectiveness research. Clin Trials. 2012;9:48-55.
16. Bourke A, Dattani H, Robinson M. Feasibility study and methodology to create a quality-evaluated database of primary care data. Inform Prim Care. 2004;12:171-177.
17. NHS Terminology Service. http://www.connectingforhealth.nhs.uk/ terminology/readcodes. 2006. Accessed 12 January 2013.
18. First Databank. MULTILEX for Primary Care. http://www.firstdatabank.co. uk/8/multilex-drug-data-file. 2010. Accessed March 2012.
19. Margulis AV, Garcia Rodriguez LA, Hernandez-Diaz S. Positive predictive value of computerized medical records for uncomplicated and complicated upper gastrointestinal ulcer. Pharmacoepidemiol Drug Saf. 2009;18:900-909.
20. Andersen IB, Jorgensen T, Bonnevie O, Gronbaek M, Sorensen TI. Smoking and alcohol intake as risk factors for bleeding and perforated peptic ulcers: a population based cohort study. Epidemiology. 2000;11:434-439.
21. Lanas A, Remacha B, Esteva F, Sainz R. Risk factors associated with refractory peptic ulcers. Gastroenterology. 1995;109:1124-1133.
22. Gabriel SE, Jaakkimainen L, Bombardier C. Risk for serious gastrointestinal complications related to use of nonsteroidal anti-inflammatory drugs. Ann Intern Med. 1991;115:787-796.
23. Patrono C, Coller B, Dalen J, et al. Platelet-active drugs: the relationships among dose, effectiveness, and side effects. Chest. 2004;126:234S-264S.
24. Fitzgerald G, Patrono C. The coxibs, selective inhibitors of cyclooxygenase-2. N Engl J Med. 2001;345:433-442.
25. Laine L. Review article: the effect of Helicobacter pylori infection on non-steroidal anti-inflammatory drug-induced upper gastrointestinal tract injury. Aliment Pharmacol Ther. 2002;16:34-39.
26. Hopkins R, Girardi L, Turney E. Relationship between Helicobacter pylori eradication and reduced duodenal and gastric ulcer recurrence: a review. Gastroenterology. 1996;110:1244-1252.