Synthesis, radioprotective activity and pharmacokinetics characteristic of a new stable nitronyl nitroxyl radical-NIT2011

Biochimie

Volumn 95, Issue 8, 2013, Pages 1574-1581

  Wang, Haibo ^a   Jia, Yujing ^a   Gao, Peng ^a   Cheng, Ying ^a   Cheng, Ming ^c   Lu, Chentao ^b   Zhou, Siyuan ^a   Sun, Xiaoli ^b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c Dima Outai Technology Development Center   (China)

Author keywords

Antioxidation; Nitronyl nitroxide radical; Pharmacokinetics; Radioprotective effect

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; AMIFOSTINE; MALONALDEHYDE; NIT 2011; RADIOPROTECTIVE AGENT; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; AMINE OXIDE; IMIDAZOLIDINE DERIVATIVE; N-3'-NITROBENZOYLPYRROLIDINYL (4,4,5,5-TETRAMETHYLIMIDAZOLINE-3-OXIDE-1-OXYL);

ACUTE TOXICITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL COUNT; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG SAFETY; DRUG SYNTHESIS; ERYTHROCYTE; GAMMA IRRADIATION; GAMMA RADIATION; HEMATOPOIETIC STEM CELL; LD 50; MAXIMUM TOLERATED DOSE; MICRONUCLEUS; MICRONUCLEUS TEST; MOUSE; NONHUMAN; RADIATION DOSE; RADIATION EXPOSURE; RADIATION PROTECTION; SPLEEN; SURVIVAL RATE; THYMUS; ANIMAL; DRUG EFFECTS; DRUG STABILITY; METABOLISM; ORAL DRUG ADMINISTRATION; RADIATION RESPONSE; SYNTHESIS; WHOLE BODY RADIATION;

MUS;

ADMINISTRATION, ORAL; ANIMALS; CYCLIC N-OXIDES; DOSE-RESPONSE RELATIONSHIP, RADIATION; DRUG STABILITY; HEMATOPOIETIC STEM CELLS; IMIDAZOLIDINES; MICE; RADIATION-PROTECTIVE AGENTS; SUPEROXIDE DISMUTASE; WHOLE-BODY IRRADIATION;

EID: 84879688880     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2013.04.011     Document Type: Article

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