Free radical scavenging and hepatoprotective effects of salidroside analogs on CCl4-induced cytotoxicity in LO2 cells

Medicinal Chemistry Research

Volumn 22, Issue 5, 2013, Pages 2524-2530

  Guo, Yibing ^a   Zheng, Cheng ^a   Xu, Wen ^a   Si, Yongxing ^a   Dou, Sufeng ^a   Yang, Yumin ^a  

^a NANTONG UNIVERSITY   (China)

Author keywords

Analogs; DPPH; Hepatoprotective effects; Salidroside

Indexed keywords

2 (3,4,5 TRIHYDROXYPHENYL)ETHYL BETA DEXTRO GALACTOPYRANOSIDE; 2 (3,4,5 TRIHYDROXYPHENYL)ETHYL BETA DEXTRO GLUCOPYRANOSIDE; AMINOTRANSFERASE; CARBON TETRACHLORIDE; GLYCOSIDE; SALIDROSIDE; SCAVENGER; UNCLASSIFIED DRUG;

AMINOTRANSFERASE BLOOD LEVEL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CYTOTOXICITY; HUMAN; IC 50; LIVER CELL; LIVER FIBROSIS; LIVER FUNCTION; LIVER PROTECTION; STELLATE CELL;

EID: 84879684468     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-012-0247-z     Document Type: Article

References (18)

1. 4 in rat liver slices. Toxicol Appl Pharmacol 112:81-86
2. Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H (2000) Rhodiola rosea in stress induced fatigue-a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine 7:365-371
3. Hoi CP, Ho YP, Baum L, Chow AH (2010) Neuroprotective effect of honokiol and magnolol, compounds from Magnolia officinalis, on beta-amyloid-induced toxicity in PC12 cells. Phytother Res 24:1538-1542
4. Hu X, Lin S, Yu D, Qiu S, Zhang X, Mei R (2010a) A preliminary study: the anti-proliferation effect of salidroside on different human cancer cell lines. Cell Biol Toxicol 26:499-507
5. Hu X, Zhang X, Qiu S, Yu D, Lin S (2010b) Salidroside induces cell-cycle arrest and apoptosis in human breast cancer cells. Biochem Biophys Res Commun 398:62-67
6. Li QY, Wang HM, Wang ZQ, Ma JF, Ding JQ, Chen SD (2010) Salidroside attenuates hypoxia-induced abnormal processing of amyloid precursor protein by decreasing BACE1 expression in SH-SY5Y cells. Neurosci Lett 481:154-158
7. McCord JM, Fridovich I (1969) Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem 244:6049-6055
8. Ouyang J, Gao Z, Ren Z, Hong D, Qiao H, Chen Y (2010) Synergistic effects of rMSCs and salidroside on the experimental hepatic fibrosis. Pharmazie 65:607-613
9. 4 and adequate model of human cirrhosis? Hepatology 3:112-120
10. Song EK, Kim JH, Kim JS, Cho H, Nan JX, Sohn DH, Ko GI, Oh H, Kim YC (2003) Hepatoprotective phenolic constituents of Rhodiola sachalinensis on tacrine-induced cytotoxicity in Hep G2 cells. Phytother Res 17:563-565
11. Su ZH, Zou GA, Preiss A, Zhang HW, Zou ZM (2010) Online identification of the antioxidant constituents of traditional Chinese medicine formula Chaihu-Shu-Gan-San by LC-LTQ-Orbitrap mass spectrometry and microplate spectrophotometer. J Pharm Biomed Anal 53:454-461
12. Wu YL, Piao DM, Han XH, Nan JX (2008) Protective effects of salidroside against acetaminophen-induced toxicity in mice. Biol Pharm Bull 31:1523-1529
13. Wu T, Zhou H, Jin Z, Bi S, Yang X, Yi D, Liu W (2009a) Cardioprotection of salidroside from ischemia/reperfusion injury by increasing N-acetylglucosamine linkage to cellular proteins. Eur J Pharmacol 613:93-99
14. Wu YL, Lian LH, Jiang YZ, Nan JX (2009b) Hepatoprotective effects of salidroside on fulminant hepatic failure induced by d-galactosamine and lipopolysaccharide in mice. J Pharm Pharmacol 61:1375-1382
15. Xiao XQ, Yang JW, Tang XC (1999) Huperzine A protects rat pheochromocytoma cells against hydrogen peroxide-induced injury. Neurosci Lett 275:73-76
16. Zhang Y, Liu Y (2005) Study on effects of salidroside on lipid peroxidation on oxidative stress in rat hepatic stellate cells. Zhong Yao Cai 28:794-796
17. Zhang J, Liu A, Hou R, Jia X, Jiang W, Chen J (2009) Salidroside protects cardiomyocyte against hypoxia-induced death: a HIF-1alpha-activated and VEGF-mediated pathway. Eur J Pharmacol 607:6-14
18. Zhang S, Chen X, Yang Y, Zhou X, Liu J, Ding F (2011) Neuroprotection against cobalt chloride-induced cell apoptosis of primary cultured cortical neurons by salidroside. Mol Cell Biochem 354:161-170