Immunomodulatory and anti-tumor effects of Nigella glandulifera freyn and sint seeds on ehrlich ascites carcinoma in mouse model

Pharmacognosy Magazine

Volumn 9, Issue 35, 2013, Pages 187-191

  Aikemu, Ainiwaer ^a   Xiaerfuding, Xiadiya ^a   Shiwenhui, Chengyufeng ^b   Abudureyimu, Meiliwan ^a   Maimaitiyiming, Dilinuer ^a  

^a XINJIANG MEDICAL UNIVERSITY   (China)

^b LANZHOU GENERAL HOSPITAL   (China)

Author keywords

Anti tumor; Immunomodulatory; Seeds of Nigella glandulifera Freyn

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 2; NIGELLA GLANDULIFERA EXTRACT; PLANT EXTRACT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; EHRLICH ASCITES TUMOR; EHRLICH ASCITES TUMOR CELL; HISTOPATHOLOGY; IMMUNOMODULATION; MOUSE; NIGELLA; NIGELLA GLANDULIFERA; NONHUMAN; PLANT SEED; PROTEIN BLOOD LEVEL;

EID: 84879652286     PISSN: 09731296     EISSN: 09764062     Source Type: Journal    
DOI: 10.4103/0973-1296.113258     Document Type: Article

References (15)

1. Yusup A, Upur H, Baudrimont I, Umar A, Kader T, Begaud B, et al. Cytotoxicity of abnormal Savda Munziq aqueous extract in human hepatoma (hepg2) cells. Fundam Clin Pharmacol 2005;19:465-72. (Pubitemid 41002417)
2. Upur H, Yusup A, Umar A, Moore N. Uighur traditional medicine syndrome of Abnormal Savda in men is associated with oxidative stress, which can be improved by Munziq and Mushil of Abnormal Savda. Therapie 2004;59:483-4. (Pubitemid 39486881)
3. Khan MA. Chemical composition and medicinal properties of Nigella sativa Linn. Inflammopharmacology 1999;7:15-35. (Pubitemid 29274788)
4. D'Antuono LF, Moretto A, Antoine FS, Lovato A. Seed yield, yield components, oil cintent and essential oil cotent and composition of nigella saliva and Nigella damascenal. Industrial crops and products 2002;15:59.
5. Merfort I, Wray KN, Barakat M, Sam M. Hussein S, M.A.M. Nawwar. Flavonol triglycosides from seeds of Nigella sative. Phytochemistry 1997;46:359-63. (Pubitemid 27391152)
6. Tian Z, Liu YM, Chen SB, Yang JS, Xiao PG, Wang L, et al. Cytotoxicity of two triterpenoids from Nigella glandulifera. Molecules 2006;11:693-9. (Pubitemid 44492707)
7. Porter KE, Turner NA, O'Regan DJ, Ball SG. Tumor necrosis factor alpha induces human atrial myofibroblast proliferation, invasion and MMP-9 secretion: Inhibition by simvastatin. Cardiovasc Res 2004;64:507-15. (Pubitemid 39505429)
8. Kim S, Choi JH, Kim JB, Nam SJ, Yang JH, Kim JH, et al. Berberine suppresses TNF-alpha-induced MMP-9 and cell invasion through inhibition of AP-1 activity in MDA-MB-231 human breast cancer cells. Molecules 2008;13:2975-85.
9. Le KH, Graham L, Miller CH, Kmieciak M, Manjili MH, Bear HD. Incubation of antigen-sensitized T lymphocytes activated with bryostatin 1 + ionomycin in IL-7 + IL-15 increases yield of cells capable of inducing regression of melanoma metastases compared to culture in IL-2. Cancer Immunol Immunother 2009 58:1565-76.
10. Voutsas IF, Baxevanis CN, Gritzapis AD, Missitzis I, Stathopoulos GP, Archodakis G, et al. Synergy between interleukin-2 and prothymosin alpha for the increased generation of cytotoxic T lymphocytes against autologous human carcinomas. Cancer Immunol Immunother 2000;49:449-58.
11. Man S, Bocci G, Francia G, Green SK, Jothy S, Hanahan D, et al. Antitumor effects in mice of low-dose (metronomic) cyclophosphamide administered continuously through the drinking water. Cancer Res 2002;62:2731-5. (Pubitemid 34525751)
12. Tao X, Tang D. Advances in the study of tumor angiogenesis and anti-angiogenic Chinese herbal drugs. Zhong Yao Cai 2003;26:379-81.
13. Goel HC, Agrawala PK, Pathania V, Malhotra N. Immunomodulatory and cytoprotective role of RP-1 in gammairradiated mice. Mol Cell Biochem 2003;254:73-81. (Pubitemid 37483741)
14. Magalhaes HI, Veras ML, Torres MR, Alves AP, Pessoa OD, Silveira ER, et al. In-vitro and in-vivo antitumour activity of physalins B and D from Physalis angulata. J Pharm Pharmacol 2006;58:235-41. (Pubitemid 43164280)
15. Goyal M, Ganguly NK, Mahajan RC. Immunological response in experimentally reactivated toxoplasmosis in mice. Med Microbiol Immunol 1989;178:269-78. China