Synthesis, characterization, and in vivo efficacy of shell cross-linked nanoparticle formulations carrying silver antimicrobials as aerosolized therapeutics

ACS Nano

Volumn 7, Issue 6, 2013, Pages 4977-4987

  Shah, Parth N ^a   Lin, Lily Yun ^b,e   Smolen, Justin A ^a   Tagaev, Jasur A ^a   Gunsten, Sean P ^c   Han, Daniel S ^c   Heo, Gyu Seong ^b   Li, Yali ^f   Zhang, Fuwu ^b   Zhang, Shiyi ^b   Wright, Brian D ^d   Panzner, Matthew J ^d   Youngs, Wiley J ^d   Brody, Steven L ^c   Wooley, Karen L ^b   Cannon, Carolyn L ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF AKRON   (United States)

^e BOSTON CHILDREN S HOSPITAL   (United States)

^f WATERS CORPORATION   (United States)

Author keywords

cystic fibrosis; multi drug resistant bacteria; nebulizable nanoparticles; Pseudomonas aeruginosa pneumonia; shell cross linked knedel like polymeric nanoparticles; silver carbene complexes

Indexed keywords

ANTI-MICROBIAL ACTIVITY; CARBENE COMPLEXES; COMBINED LOADING; CYSTIC FIBROSIS; DELIVERY SYSTEMS; POLYMERIC NANOPARTICLES; PSEUDOMONAS AERUGINOSA; SHELL CROSS-LINKED NANOPARTICLES;

BACTERIA; DRUG DOSAGE; LOADING; NANOPARTICLES; ORGANIC COMPOUNDS; PATIENT TREATMENT; POLYMERS; POSITIVE IONS; SHELLS (STRUCTURES); SYNTHESIS (CHEMICAL); TOXICITY;

SILVER;

ANTIINFECTIVE AGENT; DIAGNOSTIC AGENT; NANOPARTICLE; POLYMER; SILVER;

AEROSOL; ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; CONFORMATION; DRUG EFFECT; INFLAMMATION; LUNG; MALE; MOUSE; PSEUDOMONAS AERUGINOSA; SYNTHESIS;

AEROSOLS; ANIMALS; ANTI-INFECTIVE AGENTS; CHEMISTRY TECHNIQUES, SYNTHETIC; INFLAMMATION; LUNG; MALE; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NANOPARTICLES; POLYMERS; PSEUDOMONAS AERUGINOSA; SILVER;

EID: 84879644771     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn400322f     Document Type: Article

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