Differences in high on-treatment platelet reactivity between intracoronary and peripheral blood after dual anti-platelet agents in patients with coronary artery disease

Thrombosis and Haemostasis

Volumn 110, Issue 1, 2013, Pages 124-130

  Hu, Yu Feng ^a,b   Lu, Tse Min ^a,b   Wu, Cheng Hsueh ^a,b   Lin, Yenn Jiang ^a,b   Chang, Shih Lin ^a,b   Lo, Li Wei ^a,b   Tuan, Ta Chuan ^a,b   Chao, Tze Fan ^a,b   Chung, Fa Po ^a,b   Liao, Jo Nan ^a,b   Tzeng, Cheng Hwai ^a   Chen, Shih Ann ^a,b   Tsao, Hsuan Ming ^b  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Aspirin; Clopidogrel; Coronary artery disease; High on treatment platelet reactivity

Indexed keywords

ACETYLSALICYLIC ACID; ADRENALIN; ARACHIDONIC ACID; CLOPIDOGREL; TRIACYLGLYCEROL;

AGED; ANGIOGRAPHY; ARTICLE; BLOOD CLOTTING; CLINICAL ARTICLE; CORONARY ARTERY; CORONARY ARTERY DISEASE; CORONARY ARTERY OBSTRUCTION; FEMALE; FEMORAL ARTERY; FEMORAL VEIN; FOLLOW UP; HUMAN; MALE; MONOCYTE; NON ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; PERIPHERAL VEIN; PLATELET REACTIVITY; PRIORITY JOURNAL; RESUSCITATION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT;

AGED; AGED, 80 AND OVER; BLOOD CIRCULATION; BLOOD PLATELETS; CORONARY ARTERY DISEASE; CORONARY VESSELS; DRUG THERAPY, COMBINATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; MONOCYTES; PLATELET ACTIVATION; PLATELET AGGREGATION INHIBITORS; PLATELET FUNCTION TESTS; REGIONAL BLOOD FLOW; VEINS;

EID: 84879613740     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH13-01-0034     Document Type: Article

References (25)

1. Angiolillo DJ, Guzman LA, Bass TA. Current antiplatelet therapies: benefits and limitations. Am Heart J 2008; 156 (2 Suppl): S3-9.
2. Price MJ, Berger PB, Teirstein PS, et al. Standard- vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: the GRAVITAS randomized trial. J Am Med Assoc 2011; 305: 1097-1105.
3. Trenk D, Stone GW, Gawaz M, et al. A randomized trial of prasugrel versus clopidogrel in patients with high platelet reactivity on clopidogrel after elective percutaneous coronary intervention with implantation of drug-eluting stents: results of the TRIGGER-PCI (Testing Platelet Reactivity In Patients Undergoing Elective Stent Placement on Clopidogrel to Guide Alternative Therapy With Prasugrel) study. J Am Coll Cardiol 2012; 59: 2159-2164.
4. Gurbel PA, Tantry US. Clopidogrel response variability and the advent of personalised antiplatelet therapy. A bench to bedside journey. Thromb Haemost 2011; 106: 265-271.
5. Ahn SG, Lee SH, Yoon JH, et al. Different prognostic significance of high ontreatment platelet reactivity as assessed by the VerifyNow P2Y12 assay after coronary stenting in patients with and without acute myocardial infarction. JACC Cardiovasc Interv 2012; 5: 259-267.
6. Jaumdally RJ, Varma C, Blann AD, et al. Platelet activation in coronary artery disease: intracardiac vs peripheral venous levels and the effects of angioplasty. Chest 2007; 132: 1532-1539.
7. Willoughby SR, Roberts-Thomson RL, Lim HS, et al. Atrial platelet reactivity in patients with atrial fibrillation. Heart Rhythm 2010; 7: 1178-1183.
8. Yong AS, Pennings GJ, Chang M, et al. Intracoronary shear-related up-regulation of platelet P-selectin and platelet-monocyte aggregation despite the use of aspirin and clopidogrel. Blood 2011; 117: 11-20.
9. Botto N, Sbrana S, Trianni G, et al. An increased platelet-leukocytes interaction at the culprit site of coronary artery occlusion in acute myocardial infarction: a pathogenic role for no-reflow phenomenon? Int J Cardiol 2007; 117: 123-130.
10. Bonello L, Tantry US, Marcucci R, et al. Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate. J Am Coll Cardiol 2010; 56: 919-933.
11. Gum PA, Kottke-Marchant K, Welsh PA, et al. A prospective, blinded determination of the natural history of aspirin resistance among stable patients with cardiovascular disease. J Am Coll Cardiol 2003; 41: 961-965.
12. Lordkipanidze M, Pharand C, Schampaert E, et al. A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease. Eur Heart J 2007; 28: 1702-1708.
13. Yong AS, Pennings GJ, Chung T, et al. Intravascular blood sampling using the export catheter does not induce artifactual platelet activation. J Invasive Cardiol 2009; 21: 159-161.
14. Gresele P, Falcinelli E, Loffredo F, et al. Platelets release matrix metalloproteinase- 2 in the coronary circulation of patients with acute coronary syndromes: possible role in sustained platelet activation. Eur Heart J 2011; 32: 316-325.
15. Inokubo Y, Hanada H, Ishizaka H, et al. Plasma levels of matrix metalloproteinase- 9 and tissue inhibitor of metalloproteinase-1 are increased in the coronary circulation in patients with acute coronary syndrome. Am Heart J 2001; 141: 211-217.
16. Waehre T, Damas JK, Pedersen TM, et al. Clopidogrel increases expression of chemokines in peripheral blood mononuclear cells in patients with coronary artery disease: results of a double-blind placebo-controlled study. J Thromb Haemost 2006; 4: 2140-2147.
17. Haseruck N, Erl W, Pandey D, et al. The plaque lipid lysophosphatidic acid stimulates platelet activation and platelet-monocyte aggregate formation in whole blood: involvement of P2Y1 and P2Y12 receptors. Blood 2004; 103: 2585-2592.
18. Markuszewski L, Rosiak M, Golanski J, et al. Reduced blood platelet sensitivity to aspirin in coronary artery disease: are dyslipidaemia and inflammatory states possible factors predisposing to sub-optimal platelet response to aspirin? Basic Clin Pharmacol Toxicol 2006; 98: 503-509.
19. Hosokawa K, Ohnishi T, Sameshima H, et al. Analysing responses to aspirin and clopidogrel by measuring platelet thrombus formation under arterial flow conditions. Thromb Haemost 2013; 109: 102-111.
20. Larsen SB, Grove EL, Kristensen SD, et al. Reduced antiplatelet effect of aspirin is associated with low-grade inflammation in patients with coronary artery disease. Thromb Haemost 2013; 109: 920-929.
21. Bernlochner I, Steinhubl S, Braun S, et al. Association between inflammatory biomarkers and platelet aggregation in patients under chronic clopidogrel treatment. Thromb Haemost 2010; 104: 1193-1200.
22. Grove EL, Storey RF, Wurtz M. Platelet function testing in atherothrombotic disease. Curr Pharm Des 2012; 18: 5379-5391.
23. Grove EL, Hvas AM, Johnsen HL, et al. A comparison of platelet function tests and thromboxane metabolites to evaluate aspirin response in healthy individuals and patients with coronary artery disease. Thromb Haemost 2010; 103: 1245-1253.
24. Renda G, Zurro M, Malatesta G, et al. Inconsistency of different methods for assessing ex vivo platelet function: relevance for the detection of aspirin resistance. Haematologica 2010; 95: 2095-2101.
25. Breet NJ, van Werkum JW, Bouman HJ, et al. Comparison of platelet function tests in predicting clinical outcome in patients undergoing coronary stent implantation. J Am Med Assoc 2010; 303: 754-762.