Ethylene oxide's role as a reactive agent during sterilization: Effects of polymer composition and device architecture

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 101, Issue 4, 2013, Pages 532-540

  Phillip Jr , Edward ^a   Murthy, N Sanjeeva ^a   Bolikal, Durgadas ^a   Narayanan, Pallassana ^a   Kohn, Joachim ^a   Lavelle, Linda ^b   Bodnar, Stanko ^b   Pricer, Kurt ^b  

^a RUTGERS UNIVERSITY   (United States)

^b Johnson and Johnson   (United States)

Author keywords

Ethylene oxide sterilization; EtO susceptible groups; Fragile morphology; Poly(ethylene glycol); Tyrosine derived polycarbonates

Indexed keywords

CHEMICAL COMPOSITIONS; DEVICE ARCHITECTURES; ELECTRON MICROGRAPH; ETHYLENE OXIDES; ETO SUSCEPTIBLE GROUPS; EXPOSURE PARAMETERS; POLYMER COMPOSITION; STERILIZATION CYCLE;

AMINO ACIDS; ARCHITECTURE; MORPHOLOGY; POLYCARBONATES; POLYETHYLENE GLYCOLS; POLYMERS; SCAFFOLDS;

STERILIZATION (CLEANING);

CARBOXYL GROUP; ETHYLENE OXIDE; MACROGOL; POLYCARBONATE; TYROSINE;

ARCHITECTURE; ARTICLE; BIOCHEMICAL COMPOSITION; HUMIDITY; INSTRUMENT STERILIZATION; SURFACE PROPERTY; TEMPERATURE; TIME;

BIOCOMPATIBLE MATERIALS; CHROMATOGRAPHY, GEL; ETHYLENE OXIDE; GLASS; MAGNETIC RESONANCE SPECTROSCOPY; MATERIALS TESTING; MICROSCOPY, ELECTRON; MICROSCOPY, ELECTRON, SCANNING; MODELS, CHEMICAL; MOLECULAR WEIGHT; POLYETHYLENE GLYCOLS; POROSITY; STERILIZATION; STRESS, MECHANICAL; TEMPERATURE; TIME FACTORS; TYROSINE;

EID: 84879604680     PISSN: 15524973     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.32853     Document Type: Article

References (18)

1. Nair LS, Laurencin CT. Biodegradable polymers as biomaterials. Prog Polym Sci 2007;32(8-9):762-798. (Pubitemid 47198287)
2. Williams DF. Definitions in Biomaterials. Amsterdam: Wiley; 1987.
3. Middleton JC, Tipton AJ. Synthetic biodegradable polymers as orthopedic devices. Biomaterials 2000;21:2335-2346.
4. Block SS. Disinfection, Sterilization, and Preservation. Philadelphia, PA: Lippincott Williams & Wilkins; 2001.
5. Ratner BD, Hofman AS, Schoen FJ, Lemons JE. Biomaterials Science-An Introduction to Materials in Medicine. New York: Elsevier; 2004.
6. Hooper KA, Cox JD, Kohn J. Comparison of the effect of ethylene oxide and gamma-irradiation on selected tyrosine-derived polycarbonates and poly(L-lactic acid). J Appl Polym Sci 1997;63: 1499-1510. (Pubitemid 127598333)
7. Mendes GCC, Brandao TRS, Silva CLM. Ethylene oxide sterilization of medical devices: A review. Am J Infect Control 2007;35: 574-581. (Pubitemid 350007834)
8. Kohn J, Zeltinger J. Degradable, drug-eluting stents: A new frontier for the treatment of coronary artery disease. Expert Rev Med Devices 2005;2:667-671. (Pubitemid 41699897)
9. Khan IJ, Murthy NS, Kohn J. Study of the hydration behavior of PEG-containing copolymers in the presence of a hydrophobic drug molecule using SANS. PMSE Preprints: Polym Mater Sci Eng 2009;101:907-908.
10. James K, Levene H, Parsons JR, Kohn J. Small changes in polymer chemistry have a large effect on the bone-implant interface: Evaluation of a series of degradable tyrosine-derived polycarbonates in bone defects. Biomaterials 1999;20(23-24):2203-2212.
11. Pulapura S, Kohn J. Tyrosine-derived polycarbonates: Backbonemodified "pseudo"-poly (amino acids) designed for biomedical applications. Biopolymers 1992;32:411-417.
12. Ertel SI, Kohn J. Evaluation of a series of tyrosine-derived polycarbonates as degradable biomaterials. J Biomed Mater Res 1994; 28:919-930. (Pubitemid 24237855)
13. Yu C, Kohn J. Tyrosine-PEG-derived poly(ether carbonate)s as new biomaterials. I. Synthesis and evaluation. Biomaterials 1999; 20:253-264. (Pubitemid 29047970)
14. Magno MHR, Kim J, Srinivasan A, McBride S, Bolikal D, Darr A, Hollinger JO, Kohn J. Synthesis, degradation and biocompatibility of tyrosine-derived polycarbonate scaffolds. J Mater Chem 2010; 20:8885-8893.
15. Valenzuela LM, Michniak B, Kohn J. Variability of water uptake studies of biomedical polymers. J Appl Polym Sci 2011;121: 1311-1320.
16. Doshi J, Reneker DH. Electrospinning process and applications of electrospun fibers. J Electrostat 1995;35(2-3):151-160.
17. Bretagnol F, Rauscher H, Hasiwa M, Kylian O, Ceccone G, Hazell L, Paul AJ, Lefranc O, Rossi F. The effect of sterilization processes on the bioadhesive properties and surface chemistry of a plasmapolymerized polyethylene glycol film: XPS characterization and L929 cell proliferation tests. Acta Biomater 2008;4:1745-1751.
18. Kanjickal D, Lopina S, Evancho-Chapman MM, Schmidt S, Donovan D. Effects of sterilization on poly(ethylene glycol) hydrogels. J Biomed Mater Res A 2008;87:608-617.