Drug-induced malignant arrhythmias: IT prevents lethal drug mixtures;Medikamentös induzierte maligne Arrhythmien: EDV-Prävention verhindert tödliche Mixturen

Internist

Volumn 54, Issue 4, 2013, Pages 485-490

  Thaler, S ^a   Neumeier, C ^a   Flury, G ^a  

^a Abteilung für Innere Medizin   (Switzerland)

Author keywords

Digital electrocardiography; Escitalopram; Long QT syndrome; Methadone; Ondansetron; Torsade de pointes

Indexed keywords

ESCITALOPRAM; METHADONE; ONDANSETRON;

ARTICLE; DRUG FATALITY; DRUG MIXTURE; HEART VENTRICLE TACHYCARDIA; PATHOPHYSIOLOGY; QT PROLONGATION; TORSADE DES POINTES;

ADULT; ANALGESICS, OPIOID; ANTIDEPRESSIVE AGENTS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; CITALOPRAM; DECISION SUPPORT SYSTEMS, CLINICAL; DRUG THERAPY, COMBINATION; DRUG THERAPY, COMPUTER-ASSISTED; HUMANS; MALE; MEDICAL ORDER ENTRY SYSTEMS; METHADONE; ONDANSETRON; TORSADES DE POINTES;

EID: 84879602616     PISSN: 00209554     EISSN: 14321289     Source Type: Journal    
DOI: 10.1007/s00108-013-3246-3     Document Type: Article

References (11)

1. Eap CB, Buclin T, Baumann P (2002) Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence. Clin Pharmacokinet 41:1153-1193
2. Ehret GB, Voide C, Gex-Fabry M et al (2006) Drug induced long QT-syndrome in injection drug users receiving methadone: high frequency in hospitalized patients and risk factors. Arch Intern Med 166:1280-1287
3. Fanoe S, Hvidt C, Ege P et al (2007) Syncope and QT-prolongation among patients treated with methadone for heroin dependence randomized trial. Arch Intern Med 167:2469-2475
4. Krantz MJ, Lewkowiez L, Hays H et al (2002) Torsade de pointes associated with very-high-dose methadone. Ann Intern Med 137:501-504
5. Niveau G, Rougemont AL, La Harpe R (2002) Methadone maintenance treatment, criminality and overdose-related deaths. An ecological study, 1983-1999. Eur J Public Health 12:224-227
6. Nerbonne JM, Kass RS (2005) Molecular physiology of cardiac repolarization. Physiol Rev 85:1205-1253
7. Roden DM (2004) Drug induced prolongation of the QT-interval. N Engl J Med 350:1013-1022
8. Stringer J, Welsh C, Tommasello A (2009) Methadon-associated Q-T interval prolongation and torsades de pointes. Am J Health Syst Pharm 66:825-833
9. Yang P, Kanki H, Drolet B et al (2002) Allelic variations in long-QT disease genes in patients with drug associated torsades de pointes. Circulation 105:1943-1948
10. Kurt S, Makikallio T, Rautsharju P et al (2012) Duration of QRS complex in resting electrocardiogramm is a predictor of sudden cardiac death in men. Circulation 125:2588-2594
11. Brunner N, Falcato L, Bruggmann P (2009) Info ARUD Zürich. Eval Forsch 3:1-9