Radiation-induced galectin-1 by endothelial cells: A promising molecular target for preferential drug delivery to the tumor vasculature

Journal of Molecular Medicine

Volumn 91, Issue 4, 2013, Pages 497-506

  Upreti, Meenakshi ^a   Jamshidi Parsian, Azemat ^b   Apana, Scott ^b   Berridge, Marc ^b   Fologea, Daniel A ^c   Koonce, Nathan A ^b   Henry, Ralph L ^d   Griffin, Robert J ^b  

^a University of Kentucky   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c BOISE STATE UNIVERSITY   (United States)

^d UNIVERSITY OF ARKANSAS   (United States)

Author keywords

Anginex; Endothelial cells; Galectin 1; Tumor vasculature; Tumorendothelial cell spheroids

Indexed keywords

ANGINEX; FLUOROBENZALDEHYDE F 18; GALECTIN 1; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL LYSATE; COCULTURE; CONTROLLED STUDY; DRUG TARGETING; ENDOTHELIUM CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; TUMOR VASCULARIZATION; UPREGULATION;

ANIMALS; CELL LINE; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; FEMALE; GALECTIN 1; HUMANS; LIPOSOMES; MICE; NEOPLASMS; PEPTIDES; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; SPHEROIDS, CELLULAR; TUMOR CELLS, CULTURED;

EID: 84879601446     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-012-0965-1     Document Type: Article

References (36)

1. Maduro JH, de Vries EG, Meersma GJ, Hougardy BM, van der Zee AG, de Jong S (2008) Targeting pro-apoptotic trail receptors sensitizes HeLa cervical cancer cells to irradiation-induced apoptosis. Int J Radiat Oncol Biol Phys 72:543-552
2. Roses RE, Xu M, Koski GK, Czerniecki BJ (2008) Radiation therapy and Toll-like receptor signaling: implications for the treatment of cancer. Oncogene 27:200-207
3. Camby I, Le Mercier M, Lefranc F, Kiss R (2006) Galectin-1: a small protein with major functions. Glycobiology 16:137R-157R
4. Nagy N, Legendre H, Engels O, Andre S, Kaltner H, Wasano K, Zick Y, Pector JC, Decaestecker C, Gabius HJ et al (2003) Refined prognostic evaluation in colon carcinoma using immunohistochemical galectin fingerprinting. Cancer 97:1849-1858
5. van den Brule FA, Waltregny D, Castronovo V (2001) Increased expression of galectin-1 in carcinoma-associated stroma predicts poor outcome in prostate carcinoma patients. J Pathol 193:80-87
6. Cindolo L, Benvenuto G, Salvatore P, Pero R, Salvatore G, Mirone V, Prezioso D, Altieri V, Bruni CB, Chiariotti L (1999) Galectin-1 and galectin-3 expression in human bladder transitional-cell carcinomas. Int J Cancer 84:39-43
7. Gabius HJ, Brehler R, Schauer A, Cramer F (1986) Localization of endogenous lectins in normal human breast, benign breast lesions and mammary carcinomas. Virchows Archiv 52:107-115
8. Reynolds AR, Moein Moghimi S, Hodivala-Dilke K (2003) Nanoparticle-mediated gene delivery to tumour neovasculature. Trends Mol Med 9:2-4
9. Brannon-Peppas L, Blanchette JO (2004) Nanoparticle and targeted systems for cancer therapy. Adv Drug Deliv Rev 56:1649-1659
10. Thijssen VL, Barkan B, Shoji H, Aries IM, Mathieu V, Deltour L, Hackeng TM, Kiss R, Kloog Y, Poirier F et al (2011) Tumor cells secrete galectin-1 to enhance endothelial cell activity. Cancer Res 70:6216-6224
11. Thijssen VL, Hulsmans S, Griffioen AW (2008) The galectin profile of the endothelium: altered expression and localization in activated and tumor endothelial cells. Am J Pathol 172:545-553
12. Thijssen VL, Poirier F, Baum LG, Griffioen AW (2007) Galectins in the tumor endothelium: opportunities for combined cancer therapy. Blood 110:2819-2827
13. Thijssen VL, Postel R, Brandwijk RJ, Dings RP, Nesmelova I, Satijn S, Verhofstad N, Nakabeppu Y, Baum LG, Bakkers J et al (2006) Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy. Proc Natl Acad Sci U S A 103:15975-15980
14. Mayo KH, van der Schaft DW, Griffioen AW (2001) Designed beta-sheet peptides that inhibit proliferation and induce apoptosis in endothelial cells. Angiogenesis 4:45-51
15. Griffioen AW, van der Schaft DW, Barendsz-Janson AF, Cox A, Struijker Boudier HA, Hillen HF, Mayo KH (2001) Anginex, a designed peptide that inhibits angiogenesis. Biochem J 354:233-242
16. Thijssen VL, Barkan B, Shoji H, Aries IM, Mathieu V, Deltour L, Hackeng TM, Kiss R, Kloog Y, Poirier F et al (2010) Tumor cells secrete galectin-1 to enhance endothelial cell activity. Cancer Res 70:6216-6224
17. Kluza E, van der Schaft DW, Hautvast PA, Mulder WJ, Mayo KH, Griffioen AW, Strijkers GJ, Nicolay K (2010) Synergistic targeting of alphavbeta3 integrin and galectin-1 with heteromultivalent paramagnetic liposomes for combined MR imaging and treatment of angiogenesis. Nano Lett 10:52-58
18. Kluza E, Jacobs I, Hectors SJ, Mayo KH, Griffioen AW, Strijkers GJ, Nicolay K (2012) Dual-targeting of alphavbeta3 and galectin-1 improves the specificity of paramagnetic/fluorescent liposomes to tumor endothelium in vivo. J Control Release 158:207-214
19. 18F]fluorobenzaldehyde for targeting angiogenic activity in solid tumors. J Label Compd Radiaopharmaceuticals. doi: 10.1002/jlcr.1912
20. Jia D, Koonce NA, Halakatti R, Li X, Yaccoby S, Swain FL, Suva LJ, Hennings L, Berridge MS, Apana SM et al (2010) Repression of multiple myeloma growth and preservation of bone with combined radiotherapy and anti-angiogenic agent. Radiat Res 173:809-817
21. Upreti M, Jamshidi-Parsian A, Koonce NA, Webber JS, Sharma SK, Asea AA, Mader MJ, Griffin RJ (2011) Tumor-endothelial cell three-dimensional spheroids: new aspects to enhance radiation and drug therapeutics. Transl Oncol 4:365-376
22. Gupta K, Kshirsagar S, Li W, Gui L, Ramakrishnan S, Gupta P, Law PY, Hebbel RP (1999) VEGF prevents apoptosis of human microvascular endothelial cells via opposing effects on MAPK/ERK and SAPK/JNK signaling. Exp Cell Res 247:495-504
23. Wu X, Lensch MW, Wylie-Sears J, Daley GQ, Bischoff J (2007) Hemogenic endothelial progenitor cells isolated from human umbilical cord blood. Stem Cells (Dayton, Ohio) 25:2770-2776
24. Ma CM, Coffey CW, DeWerd LA, Liu C, Nath R, Seltzer SM, Seuntjens JP (2001) AAPM protocol for 40-300 kV X-ray beam dosimetry in radiotherapy and radiobiology. Med Phys 28:868-893
25. Wahl RL, Jacene H, Kasamon Y, Lodge MA (2009) From RECIST to PERCIST: evolving considerations for PET response criteria in solid tumors. J Nucl Med 50(Suppl 1):122S-150S
26. Dings RP, Arroyo MM, Lockwood NA, van Eijk LI, Haseman JR, Griffioen AW, Mayo KH (2003) Beta-sheet is the bioactive conformation of the anti-angiogenic anginex peptide. Biochem J 373:281-288
27. He J, Baum LG (2004) Presentation of galectin-1 by extracellular matrix triggers T cell death. J Biol Chem 279:4705-4712
28. He J, Baum LG (2006) Endothelial cell expression of galectin-1 induced by prostate cancer cells inhibits T-cell transendothelial migration. Lab Investig; A J Tech Methods Pathol 86:578-590
29. Rabinovich GA, Ariel A, Hershkoviz R, Hirabayashi J, Kasai KI, Lider O (1999) Specific inhibition of T-cell adhesion to extracellular matrix and proinflammatory cytokine secretion by human recombinant galectin-1. Immunology 97:100-106
30. van den Brule F, Califice S, Garnier F, Fernandez PL, Berchuck A, Castronovo V (2003) Galectin-1 accumulation in the ovary carcinoma peritumoral stroma is induced by ovary carcinoma cells and affects both cancer cell proliferation and adhesion to laminin-1 and fibronectin. Laboratory Investig; A J Tech Methods Pathol 83:377-386
31. Le QT, Shi G, Cao H, Nelson DW, Wang Y, Chen EY, Zhao S, Kong C, Richardson D, O'Byrne KJ et al (2005) Galectin-1: a link between tumor hypoxia and tumor immune privilege. J Clin Oncol 23:8932-8941
32. Moeller BJ, Dreher MR, Rabbani ZN, Schroeder T, Cao Y, Li CY, Dewhirst MW (2005) Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. Cancer Cell 8:99-110
33. Ahmed MM (2004) Regulation of radiation-induced apoptosis by early growth response-1 gene in solid tumors. Current Cancer Drug Targets 4:43-52
34. Fu M, Zhu X, Zhang J, Liang J, Lin Y, Zhao L, Ehrengruber MU, Chen YE (2003) Egr-1 target genes in human endothelial cells identified by microarray analysis. Gene 315:33-41
35. Moeller BJ, Cao Y, Li CY, Dewhirst MW (2004) Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell 5:429-441
36. Zhao XY, Chen TT, Xia L, Guo M, Xu Y, Yue F, Jiang Y, Chen GQ, Zhao KW (2019) Hypoxia inducible factor-1 mediates expression of galectin-1: the potential role in migration/invasion of colorectal cancer cells. Carcinogenesis 31:1367-1375