Cardiac transplantation with hearts from donors after circulatory declaration of death: Haemodynamic and biochemical parameters at procurement predict recovery following cardioplegic storage in a rat model

European Journal of Cardio-thoracic Surgery

Volumn 44, Issue 1, 2013, Pages

  Sourdon, Joevin ^a   Dornbierer, Monika ^a   Huber, Simon ^a   Gahl, Brigitta ^a   Carrel, Thierry P ^a   Tevaearai, Hendrik T ^a   Longnus, Sarah L ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Cardiac graft evaluation; Donation after cardiac death; Donation after circulatory declaration of death; Heart transplantation; Ischaemia reperfusion; Isolated rat heart; Non heart beating donors

Indexed keywords

LACTATE DEHYDROGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOPLEGIA; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORRELATION ANALYSIS; DEATH; ENZYME RELEASE; HEART LEFT VENTRICLE FUNCTION; HEART PERFUSION; HEART RATE; HEART TRANSPLANTATION; HEMODYNAMICS; ISCHEMIA; ISOLATED HEART; MALE; NONHUMAN; ORGAN DONOR; ORGAN PRESERVATION; OXYGEN CONSUMPTION; PREDICTION; PRIORITY JOURNAL; RAT; REPERFUSION; SIMULATION; SYSTOLIC BLOOD PRESSURE;

CARDIAC GRAFT EVALUATION; DONATION AFTER CARDIAC DEATH; DONATION AFTER CIRCULATORY DECLARATION OF DEATH; HEART TRANSPLANTATION; ISCHAEMIA-REPERFUSION; ISOLATED RAT HEART; NON-HEART BEATING DONORS;

ANIMALS; CARDIOPLEGIC SOLUTIONS; HEART TRANSPLANTATION; HEMODYNAMICS; HUMANS; MALE; RATS; RATS, WISTAR; REPERFUSION; STATISTICS, NONPARAMETRIC; TRANSPLANTS; TREATMENT OUTCOME;

EID: 84879594405     PISSN: 10107940     EISSN: 1873734X     Source Type: Journal    
DOI: 10.1093/ejcts/ezt142     Document Type: Article

References (25)

1. Osaki S, Anderson JE, Johnson MR, Edwards NM, Kohmoto T. The potential of cardiac allografts from donors after cardiac death at the University of Wisconsin Organ Procurement Organization. Eur J Cardiothorac Surg 2010;37:74-9.
2. Doig CJ, Rocker G. Retrieving organs from non-heart-beating organ donors: a review of medical and ethical issues. Can J Anaesth 2003;50: 1069-76.
3. Singhal AK, Abrams JD, Mohara J, Hasz RD, Nathan HM, Fisher CA et al. Potential suitability for transplantation of hearts from human non-heart-beating donors: data review from the Gift of Life Donor Program. J Heart Lung Transplant 2005;24:1657-64.
4. Ali A, White P, Dhital K, Ryan M, Tsui S, Large S. Cardiac recovery in a human non-heart-beating donor after extracorporeal perfusion: source for human heart donation?. J Heart Lung Transplant 2009;28: 290-3.
5. Boucek MM, Mashburn C, Dunn SM, Frizell R, Edwards L, Pietra B et al. Pediatric heart transplantation after declaration of cardiocirculatory death. N Engl J Med 2008;359:709-14.
6. Whetstine L, Bowman K, Hawryluck L. Pro/con ethics debate: is nonheart-beating organ donation ethically acceptable?. Crit Care 2002;6: 192-5.
7. Hearse DJ. Myocardial protection during ischemia and reperfusion. Mol Cell Biochem 1998;186:177-84.
8. Koike N, Takeyoshi I, Ohki S, Tsutsumi H, Matsumoto K, Morishita Y. The effect of short-term coronary perfusion using a perfusion apparatus on canine heart transplantation from non-heart-beating donors. J Heart Lung Transplant 2003;22:810-7.
9. Scheule AM, Haas J, Zurakowski D, Strotmann C, Michel F, Vogel U et al. A non-heart-beating donor model to evaluate functional and morphologic outcomes in resuscitated pig hearts. J Invest Surg 2002;15:125-35.
10. Kootstra G. Statement on non-heart-beating donor programs. Transplant Proc 1995;27:2965.
11. Kato G, Ishino K, Mohri M, Hisamochi K, Takagaki M, Sano S. Efficacy of an endothelin-A receptor antagonist in heart transplantation from asphyxiated canine non-heart-beating donors. Jpn J Thorac Cardiovasc Surg 2006;54:511-5.
12. Osaki S, Ishino K, Kotani Y, Honjo O, Suezawa T, Kohmoto T et al. Circulatory load during hypoxia impairs post-transplant myocardial functional recovery in donation after cardiac death. J Heart Lung Transplant 2009;28:266-72.
13. Ferrera R, Bopassa JC, Rodriguez C, Baverel G, Ovize M. A simple and reliable method to assess heart viability after hypothermic procurement. Transplant Proc 2006;38:2283-4.
14. Suehiro K, Mohri M, Yamaguchi H, Takagaki M, Hisamochi K, Morimoto T et al. Posttransplant function of a nonbeating heart is predictable by an ex vivo perfusion method. Ann Thorac Surg 2001;71:278-83.
15. Hirota M, Ishino K, Fukumasu I, Yoshida K, Mohri S, Shimizu J et al. Prediction of functional recovery of 60-minute warm ischemic hearts from asphyxiated canine non-heart-beating donors. J Heart Lung Transplant 2006;25:339-44.
16. Collins MJ, Ozeki T, Zhuo J, Gu J, Gullapalli R, Pierson RN et al. Use of diffusion tensor imaging to predict myocardial viability after warm global ischemia: possible avenue for use of non-beating donor hearts. J Heart Lung Transplant 2007;26:376-83.
17. Dornbierer M, Stadelmann M, Sourdon J, Gahl B, Cook S, Carrel T et al. Early reperfusion hemodynamics predict recovery in ischemic rat hearts: a potentially simple and rapid approach towards evaluating cardiac grafts from non-heart-beating donors. PLoS One 2012;7:e43642.
18. Neely JR, Liebermeister H, Battersby EJ, Morgan HE. Effect of pressure development on oxygen consumption by isolated rat heart. Am J Physiol 1967;212:804-14.
19. Lopaschuk GD, Wambolt RB, Barr RL. An imbalance between glycolysis and glucose oxidation is a possible explanation for the detrimental effects of high levels of fatty acids during aerobic reperfusion of ischemic hearts. J Pharmacol Exp Ther 1993;264:135-44.
20. Saddik M, Lopaschuk GD. Myocardial triglyceride turnover and contribution to energy substrate utilization in isolated working rat hearts. J Biol Chem 1991;266:8162-70.
21. Holland BS, Copenhaver MD. An improved sequentially rejective Bonferroni test procedure. Biometrics 1987;43:417-23.
22. Manara AR, Murphy PG, O'Callaghan G. Donation after circulatory death. Br J Anaesth 2012;108 (Suppl 1):i108-21.
23. Monbaliu D, Pirenne J, Talbot D. Liver transplantation using donation after cardiac death donors. J Hepatol 2012;56:474-85.
24. Doenst T, Guthrie PH, Taegtmeyer H. Ischemic preconditioning in rat heart: no correlation between glycogen content and return of function. Mol Cell Biochem 1998;180:153-61.
25. Mackersie RC, Bronsther OL, Shackford SR. Organ procurement in patients with fatal head injuries. The fate of the potential donor. Ann Surg 1991;213:143-50.