Determination of leelamine in mouse plasma by LC-MS/MS and its pharmacokinetics

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 931, Issue , 2013, Pages 170-173

  Song, Min ^a   Lee, Doohyun ^a   Lee, Taeho ^a   Lee, Sangkyu ^a  

^a Kyungpook National University   (South Korea)

Author keywords

Bioavailability; LC MS MS; Leelamine; Mouse; Pharmacokinetic

Indexed keywords

BIOAVAILABILITY; LC-MS/MS; LEELAMINE; LOWER LIMIT OF QUANTIFICATIONS; MOUSE; PYRUVATE DEHYDROGENASE KINASE; QUANTIFICATION METHODS; TANDEM MASS SPECTROMETRY;

BIOCHEMISTRY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS; PLASMAS; QUALITY CONTROL;

MAMMALS;

ACETONITRILE; DITERPENE; FORMIC ACID; LEELAMINE; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONCENTRATION RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DETERMINATION; FLOW RATE; LIQUID CHROMATOGRAPHY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; ANIMAL; BLOOD; CHEMISTRY; INSTITUTE FOR CANCER RESEARCH MOUSE; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

ANIMALS; CHROMATOGRAPHY, LIQUID; DITERPENES; MALE; MICE; MICE, INBRED ICR; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 84879593051     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2013.05.018     Document Type: Article

References (5)

1. Cadoudal T., Distel E., Durant S., Fouque F., Blouin J.M., Collinet M., Bortoli S., Forest C., Benelli C. Diabetes 2008, 57:2272.
2. Aicher T.D., Damon R.E., Koletar J., Vinluan C.C., Brand L.J., Gao J., Shetty S.S., Kaplan E.L., Mann W.R. Bioorg. Med. Chem. Lett. 1999, 9:2223.
3. Lovinger D.M. Handbook of Experimental Pharmacology 2008, 435.
4. Bakhtiar R., Majumdar T.K. J. Pharmacol. Toxicol. Methods 2007, 55:262.
5. Cesari N., Fontana S., Montanari D., Braggio S. J. Chromatogr. B 2010, 878:21.