The antiprion compound 6-aminophenanthridine inhibits the protein folding activity of the ribosome by direct competition

Journal of Biological Chemistry

Volumn 288, Issue 26, 2013, Pages 19081-19089

  Pang, Yanhong ^a   Kurella, Sriram ^a   Voisset, Cécile ^b   Samanta, Dibyendu ^c,e   Banerjee, Debapriya ^a   Schabe, Ariane ^a,f   Gupta, Chanchal Das ^c   Galons, Hervé ^d   Blondel, Marc ^b   Sanyal, Suparna ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UNIVERSITÉ DE BRETAGNE OCCIDENTALE   (France)

^c UNIVERSITY OF CALCUTTA   (India)

^d UNIVERSITÉ PARIS DESCARTES   (France)

^e ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^f MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PATTERN; FOLDING MODULATOR; HUMAN CARBONIC ANHYDRASES; INTERACTION SITE; KINETIC ANALYSIS; PRIMER EXTENSION; PROTEIN SUBSTRATE; RIBOSOMAL SUBUNITS;

BINDING SITES; CARBONIC ANHYDRASE; ESCHERICHIA COLI; MACROMOLECULES; PROTEIN FOLDING; RNA; YEAST;

PROTEINS;

6 AMINOPHENANTHRIDINE; CARBONATE DEHYDRATASE; PHENANTHRIDINE DERIVATIVE; RIBOSOME RNA; UNCLASSIFIED DRUG;

ARTICLE; BINDING COMPETITION; CONTROLLED STUDY; ENZYME KINETICS; MUTATION; NUCLEOTIDE BINDING SITE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN FOLDING ACTIVITY OF THE RIBOSOME; PROTEIN REFOLDING; RIBOSOME; RNA BINDING;

6AP; MOLECULAR CHAPERONE; PRIONS; PROTEIN FOLDING; RIBOSOMAL RNA (RRNA); RIBOSOMES;

AMINO ACID SEQUENCE; BASE SEQUENCE; BINDING SITES; BINDING, COMPETITIVE; CARBONIC ANHYDRASES; ESCHERICHIA COLI; HUMANS; MOLECULAR CHAPERONES; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTATION; NUCLEIC ACID CONFORMATION; PHENANTHRIDINES; PRIONS; PROTEIN BINDING; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; RIBOSOMES; RNA, RIBOSOMAL; SEQUENCE HOMOLOGY, AMINO ACID;

ESCHERICHIA COLI; EUKARYOTA; PROKARYOTA; SACCHAROMYCES CEREVISIAE;

EID: 84879591681     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.466748     Document Type: Article

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