Impact of delay in clinical presentation on the diagnostic management and prognosis of patients with suspected pulmonary embolism

American Journal of Respiratory and Critical Care Medicine

Volumn 187, Issue 12, 2013, Pages 1369-1373

  Den Exter, Paul L ^a   Van Es, Josien ^b   Erkens, Petra M G ^c   Van Roosmalen, Mark J G ^a   Van Den Hoven, Pim ^a   Hovens, Marcel M C ^d   Kamphuisen, Pieter W ^e   Klok, Frederikus A ^a   Huisman, Menno V ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^d RIJNSTATE HOSPITAL   (Netherlands)

^e UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Diagnosis; Diagnostic delay; Duration of symptoms; Prognosis; Pulmonary embolism

Indexed keywords

D DIMER;

ADULT; ARTICLE; CLINICAL FEATURE; DELAYED DIAGNOSIS; FEMALE; FOLLOW UP; HUMAN; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; PROBABILITY; PROGNOSIS; RECURRENT DISEASE; SENSITIVITY AND SPECIFICITY; VENOUS THROMBOEMBOLISM;

DELAYED DIAGNOSIS; FEMALE; HUMANS; MALE; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDIES; PULMONARY EMBOLISM;

EID: 84879579810     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201212-2219OC     Document Type: Article

References (17)

1. Huisman MV, Klok FA. Diagnostic management of clinically suspected acute pulmonary embolism. J Thromb Haemost 2009;7: 312-317.
2. Ageno W, Agnelli G, Imberti D, Moia M, Palareti G, Pistelli R, Rossi R, Verso M; MASTER Investigators. Factors associated with the timing of diagnosis of venous thromboembolism: results from the MASTER registry. Thromb Res 2008;121: 751-756.
3. Wood KE. Major pulmonary embolism: review of a pathophysiologic approach to the golden hour of hemodynamically significant pulmonary embolism. Chest 2002;121: 877-905.
4. Pasha SM, Klok FA, Snoep JD, Mos IC, Goekoop RJ, Rodger MA, Huisman MV. Safety of excluding acute pulmonary embolism based on an unlikely clinical probability by the Wells rule and normal D-dimer concentration: a meta-analysis. Thromb Res 2010;125: e123-e127.
5. Kraaijenhagen RA, Wallis J, Koopman MM, de Groot MR, Piovella F, Prandoni P, Büller HR. Can causes of false-normal D-dimer test [SimpliRED] results be identified? Thromb Res 2003;111: 155-158.
6. Douma RA, Mos IC, Erkens PM, Nizet TA, Durian MF, Hovens MM, van Houten AA, Hofstee HM, Klok FA, ten Cate H, et al.; Prometheus Study Group. Performance of 4 clinical decision rules in the diagnostic management of acute pulmonary embolism: a prospective cohort study. Ann Intern Med 2011;154: 709-718.
7. van Belle A, Büller HR, Huisman MV, Huisman PM, Kaasjager K, Kamphuisen PW, Kramer MH, Kruip MJ, Kwakkel-van Erp JM, Leebeek FW, et al.; Christopher Study Investigators. Effectiveness of managing suspected pulmonary embolism using an algorithm combining clinical probability, D-dimer testing, and computed tomography. JAMA 2006;295: 172-179.
8. Wells PS, Anderson DR, Rodger M, Ginsberg JS, Kearon C, Gent M, Turpie AG, Bormanis J, Weitz J, Chamberlain M, et al. Derivation of a simple clinical model to categorize patients probability of pulmonary embolism: increasing the models utility with the SimpliRED D-dimer. Thromb Haemost 2000;83: 416-420.
9. Tapson VF. Acute pulmonary embolism. N Engl J Med 2008;358: 1037-1052.
10. Elliott CG, Goldhaber SZ, Jensen RL. Delays in diagnosis of deep vein thrombosis and pulmonary embolism. Chest 2005;128: 3372-3376.
11. Jiménez Castro D, Sueiro A, Díaz G, Escobar C, García-Rull S, Picher J, Taboada D, Yusen RD. Prognostic significance of delays in diagnosis of pulmonary embolism. Thromb Res 2007;121: 153-158.
12. van Beek EJ, Brouwerst EM, Song B, Stein PD, Oudkerk M. Clinical validity of a normal pulmonary angiogram in patients with suspected pulmonary embolism: a critical review. Clin Radiol 2001;56: 838-842.
13. Bruinstroop E, van de Ree MA, Huisman MV. The use of D-dimer in specific clinical conditions: a narrative review. Eur J Intern Med 2009; 20: 441-446.
14. de Bastos M, de Bastos MR, Bogutchi T, Carneiro-Proietti AB, Rezende SM. Duration of symptoms and D-dimer testing in the ruling-out of venous thromboembolism. J Thromb Haemost 2006;4: 2079-2080.
15. Stein PD, Hull RD, Patel KC, Olson RE, Ghali WA, Brant R, Biel RK, Bharadia V, Kalra NK. D-dimer for the exclusion of acute venous thrombosis and pulmonary embolism: a systematic review. Ann Intern Med 2004;140: 589-602.
16. Vedovati MC, Becattini C, Agnelli G, Kamphuisen PW, Masotti L, Pruszczyk P, Casazza F, Salvi A, Grifoni S, Carugati A, et al. Multidetector CT scan for acute pulmonary embolism: embolic burden and clinical outcome. Chest 2012;142: 1417-1424.
17. Klok FA, Zondag W, van Kralingen KW, van Dijk AP, Tamsma JT, Heyning FH, Vliegen HW, Huisman MV. Patient outcomes after acute pulmonary embolism. A pooled survival analysis of different adverse events. Am J Respir Crit Care Med 2010;181: 501-506.