Design, synthesis, and initial evaluation of a high affinity positron emission tomography probe for imaging matrix metalloproteinases 2 and 9

Journal of Medicinal Chemistry

Volumn 56, Issue 12, 2013, Pages 4912-4920

  Selivanova, Svetlana V ^a   Stellfeld, Timo ^b   Heinrich, Tobias K ^b   Müller, Adrienne ^a   Krämer, Stefanie D ^a   Schubiger, P August ^a   Schibli, Roger ^a   Ametamey, Simon M ^a   Vos, Bernhard ^b   Meding, Jörg ^b   Bauser, Marcus ^b   Hütter, Joachim ^b   Dinkelborg, Ludger M ^b  

^a ETH ZURICH   (Switzerland)

^b Bayer HealthCare   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 (4 FLUOROBENZAMIDO)PHENYLSULFONAMIDO) 3 (1H INDOL 3 YL)PROPANOIC ACID; DIPHENYLIODONIUM SALT; FLUORINE 18; GELATINASE A; GELATINASE B; N SULFONYLAMINO ACID DERIVATIVE; RADIOISOTOPE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; COMPUTER ASSISTED EMISSION TOMOGRAPHY; DRUG BINDING; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; FEMALE; IC 50; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG DESIGN; FLUORINE RADIOISOTOPES; HUMANS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASE INHIBITORS; MICE; MICE, INBRED C57BL; MULTIMODAL IMAGING; POSITRON-EMISSION TOMOGRAPHY; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84879573571     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400156p     Document Type: Article

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