Effects of intravenous propranolol on heat pain sensitivity in healthy men

European Journal of Pain (United Kingdom)

Volumn 17, Issue 5, 2013, Pages 704-713

  Schweinhardt, P ^a   Abulhasan, Y B ^b,c   Koeva, V ^b   Balderi, T ^b   Kim, D J ^b   Alhujairi, M ^b   Carli, F ^b  

^a MCGILL UNIVERSITY   (Canada)

^b MONTREAL GENERAL HOSPITAL   (Canada)

^c KUWAIT UNIVERSITY   (Kuwait)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; PROPRANOLOL; SOTALOL;

ADULT; ANALGESIC ACTIVITY; ANXIETY; ARTICLE; BODY WEIGHT; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; FOLLOW UP; HEAT SENSITIVITY; HUMAN; LIPOPHILICITY; MALE; NOCICEPTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEDATION; SYSTOLIC BLOOD PRESSURE;

ADOLESCENT; ADRENERGIC BETA-ANTAGONISTS; ADULT; AFFECT; BLOOD PRESSURE; DOUBLE-BLIND METHOD; HOT TEMPERATURE; HUMANS; INJECTIONS, INTRAVENOUS; MALE; PAIN; PAIN THRESHOLD; PROPRANOLOL; YOUNG ADULT;

EID: 84879572140     PISSN: 10903801     EISSN: 15322149     Source Type: Journal    
DOI: 10.1002/j.1532-2149.2012.00231.x     Document Type: Article

References (40)

1. Alhaider, A.A., Wilcox, G.L. (1993). Differential roles of 5-hydroxytryptamine1A and 5-hydroxytryptamine1B receptor subtypes in modulating spinal nociceptive transmission in mice. J Pharmacol Exp Ther 265, 378-385.
2. Borchard, U. (1998). Pharmacological properties of betaadrenoreceptor blocking drugs. J Clin Bas Cardiol 1, 5-9.
3. Bruehl, S., Chung, O.Y. (2004). Interactions between the cardiovascular and pain regulatory systems: An updated review of mechanisms and possible alterations in chronic pain. Neurosci Biobehav Rev 28, 395-414.
4. Chia, Y.Y., Chan, M.H., Ko, N.H., Liu, K. (2004). Role of betablockade in anaesthesia and postoperative pain management after hysterectomy. Br J Anaesth 93, 799-805.
5. Collard, V., Mistraletti, G., Taqi, A., Asenjo, J.F., Feldman, L.S., Fried, G.M., Carli, F. (2007). Intraoperative esmolol infusion in the absence of opioids spares postoperative fentanyl in patients undergoing ambulatory laparoscopic cholecystectomy. Anesth Analg 105, 1255-1262.
6. Coloma, M., Chiu, J.W., White, P.F., Armbruster, S.C. (2001). The use of esmolol as an alternative to remifentanil during desflurane anesthesia for fast-track outpatient gynecologic laparoscopic surgery. Anesth Analg 92, 352-357.
7. Davidson, E.M., Doursout, M.F., Szmuk, P., Chelly, J.E. (2001). Antinociceptive and cardiovascular properties of esmolol following formalin injection in rats. Can J Anaesth 48, 59-64.
8. de Oliveira, G.G., Borges, M.A. (1994). Propranolol action in chronically unstable generalized epilepsy. Am J Ther 1, 38-41.
9. Deyama, S., Takishita, A., Tanimoto, S., Ide, S., Nakagawa, T., Satoh, M., Minami, M. (2010). Roles of beta- and alpha2- adrenoceptors within the central nucleus of the amygdala in the visceral pain-induced aversion in rats. J Pharmacol Sci 114, 123-126.
10. Ernberg, M., Lundeberg, T., Kopp, S. (2000). Effect of propranolol and granisetron on experimentally induced pain and allodynia/hyperalgesia by intramuscular injection of serotonin into the human masseter muscle. Pain 84, 339-346.
11. Farrar, J.T., Young, J.P., Jr. LaMoreaux, L., Werth, J.L., Poole, R.M. (2001). Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale. Pain 94, 149-158.
12. Favaro-Moreira, N.C., Parada, C.A., Tambeli, C.H. (2012). Blockade of beta(1) -, beta(2) - and beta(3) -adrenoceptors in the temporomandibular joint induces antinociception especially in female rats. Eur J Pain 16, 1302-1310.
13. File, S.E., Lister, R.G. (1985). A comparison of the effects of lorazepam with those of propranolol on experimentallyinduced anxiety and performance. Br J Clin Pharmacol 19, 445-451.
14. Fischer, W. (2002). Anticonvulsant profile and mechanism of action of propranolol and its two enantiomers. Seizure 11, 285-302.
15. Gramigni, E., Schweinhardt, P., Baldini, G., Clemente, A., Bushnell, M., Carli, F. (2008). Propranolol decreases pain perception in healthy volunteers. Can J Anaesth 55 (Suppl. 1), 474981.
16. Hu, A., Jiao, X., Gao, E., Li, Y., Sharifi-Azad, S., Grunwald, Z., Ma, X.L., Sun, J.Z. (2008). Tonic beta-adrenergic drive provokes proinflammatory and proapoptotic changes in aging mouse heart. Rejuvenation Res 11, 215-226.
17. Kayser, V., Elfassi, I.E., Aubel, B., Melfort, M., Julius, D., Gingrich, J.A., Hamon, M., Bourgoin, S. (2007). Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A-/-, 5-HT1B-/-, 5-HT2A-/-, 5-HT3A-/- and 5-HTT-/- knock-out male mice. Pain 130, 235-248.
18. Khasar, S.G., McCarter, G., Levine, J.D. (1999). Epinephrine produces a beta-adrenergic receptor-mediated mechanical hyperalgesia and in vitro sensitization of rat nociceptors. J Neurophysiol 81, 1104-1112.
19. Laverdure, B., Boulenger, J.P. (1991). Beta-blocking drugs and anxiety. A proven therapeutic value. Encephale 17, 481-492.
20. Light, A.R., Bateman, L., Jo, D., Hughen, R.W., Vanhaitsma, T.A., White, A.T., Light, K.C. (2011). Gene expression alterations at baseline and following moderate exercise in patients with Chronic Fatigue Syndrome and Fibromyalgia Syndrome. J Intern Med 271, 64-81.
21. Light, K.C., Bragdon, E.E., Grewen, K.M., Brownley, K.A., Girdler, S.S., Maixner, W. (2009). Adrenergic dysregulation and pain with and without acute beta-blockade in women with fibromyalgia and temporomandibular disorder. J Pain 10, 542-552.
22. Lin, Q., Peng, Y.B., Willis, W.D. (1996). Antinociception and inhibition from the periaqueductal gray are mediated in part by spinal 5- hydroxytryptamine(1A) receptors. J Pharmacol Exp Ther 276, 958-967.
23. Luchowska, E., Luchowski, P., Wielosz, M., Kleinrok, Z., Czuczwar, S.J., Urbanska, E.M. (2002). Propranolol and metoprolol enhance the anticonvulsant action of valproate and diazepam against maximal electroshock. Pharmacol Biochem Behav 71, 223-231.
24. McAinsh, J., Cruickshank, J.M. (1990). Beta-blockers and central nervous system side effects. Pharmacol Ther 46, 163-197.
25. McCubbin, J.A., Bruehl, S. (1994). Do endogenous opioids mediate the relationship between blood pressure and pain sensitivity in normotensives? Pain 57, 63-67.
26. Meyer, R.A., Ringkamp, M., Campbell, J.N., Raja, S.N. (2005). Peripheral mechanisms of nociception. In Textbook of Pain, S. McMahon, M. Koltzenburg, eds. (Philadelphia: Elsevier- Churchill-Livingstone) pp. 3-34.
27. Nackley, A.G., Tan, K.S., Fecho, K., Flood, P., Diatchenko, L., Maixner, W. (2007). Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors. Pain 128, 199-208.
28. Ploghaus, A., Narain, C., Beckmann, C.F., Clare, S., Bantick, S., Wise, R., Matthews, P.M., Rawlins, J.N., Tracey, I. (2001). Exacerbation of pain by anxiety is associated with activity in a hippocampal network. J Neurosci 21, 9896-9903.
29. Randich, A., Maixner, W. (1984). Interactions between cardiovascular and pain regulatory systems. Neurosci Biobehav Rev 8, 343-367.
30. Rhudy, J.L., Meagher, M.W. (2000). Fear and anxiety: Divergent effects on human pain thresholds. Pain 84, 65-75.
31. Rodrigues, L.L., Oliveira, M.C., Pelegrini-Da-Silva, A., Veiga, M.C., Parada, C.A., Tambeli, C.H. (2006). Peripheral sympathetic component of the temporomandibular joint inflammatory pain in rats. J Pain 7, 929-936.
32. Rosier, E.M., Iadarola, M.J., Coghill, R.C. (2002). Reproducibility of pain measurement and pain perception. Pain 98, 205- 216.
33. Tan, K.S., Nackley, A.G., Satterfield, K., Maixner, W., Diatchenko, L., Flood, P.M. (2007). Beta2 adrenergic receptor activation stimulates pro-inflammatory cytokine production in macrophages via PKA- and NF-kappaB-independent mechanisms. Cell Signal 19, 251-260.
34. Tchivileva, I.E., Lim, P.F., Smith, S.B., Slade, G.D., Diatchenko, L., McLean, S.A., Maixner, W. (2010). Effect of catechol-Omethyltransferase polymorphism on response to propranolol therapy in chronic musculoskeletal pain: A randomized, double-blind, placebo-controlled, crossover pilot study. Pharmacogenet Genomics 20, 239-248.
35. Villemure, C., Slotnick, B.M., Bushnell, M.C. (2003). Effects of odors on pain perception: Deciphering the roles of emotion and attention. Pain 106, 101-108.
36. Wohleb, E.S., Hanke, M.L., Corona, A.W., Powell, N.D., Stiner, L.M., Bailey, M.T., Nelson, R.J., Godbout, J.P., Sheridan, J.F. (2011). beta-Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat. J Neurosci 31, 6277-6288.
37. Wood, A.J., Feely, J. (1983). Pharmacokinetic drug interactions with propranolol. Clin Pharmacokinet 8, 253-262.
38. Ylitalo, P., Linden, I.B., Penttila, A., Vapaatalo, H. (1986). Distribution of beta-adrenoceptor blocking drugs into cerebrospinal fluid in rats. Acta Pharmacol Toxicol (Copenh) 58, 84-87.
39. Zhao, H., Sugawara, T., Miura, S., Iijima, T., Kashimoto, S. (2007). Intrathecal landiolol inhibits nociception and spinal c-Fos expression in the mouse formalin test. Can J Anaesth 54, 201-207.
40. Zoller, W.G., Wagner, D.R., Zentner, J. (1993). Effect of propranolol on portal vein hemodynamics: Assessment by duplex sonography and indocyanine green clearance in healthy volunteers. Clin Investig 71, 654-658.