Systematic Analysis of the Functions of Lysine Acetylation in the Regulation of Tat Activity

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  He, Minghao ^a   Zhang, Linlin ^a   Wang, Xincheng ^a   Huo, Lihong ^a   Sun, Lei ^b   Feng, Chengye ^a   Jing, Xutian ^a   Du, Danyao ^a   Liang, Huabin ^a   Liu, Min ^b   Hong, Zhangyong ^a   Zhou, Jun ^a  

^a NANKAI UNIVERSITY   (China)

^b TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

LYSINE; TRANSACTIVATOR PROTEIN; ALANINE; ARGININE; GLUTAMINE; PROTEIN BINDING;

ACETYLATION; APOPTOSIS; ARTICLE; CELL ACTIVITY; CELLULAR DISTRIBUTION; CORRELATION ANALYSIS; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; MITOSIS; MUTATIONAL ANALYSIS; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; TRANSACTIVATION; GENETICS; HEK293 CELL LINE; HUMAN IMMUNODEFICIENCY VIRUS 1; JURKAT CELL LINE; METABOLISM; MICROTUBULE; MUTATION; PHYSIOLOGY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ACETYLATION; ALANINE; APOPTOSIS; ARGININE; GLUTAMINE; HEK293 CELLS; HIV-1; HUMANS; JURKAT CELLS; LYSINE; MICROTUBULES; MITOSIS; MUTATION; PROTEIN BINDING; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS;

EID: 84879541949     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067186     Document Type: Article

References (34)

1. Pugliese A, Vidotto V, Beltramo T, Petrini S, Torre D, (2005) A review of HIV-1 Tat protein biological effects. Cell Biochem Funct 23: 223-227.
2. Gibellini D, Vitone F, Schiavone P, Re MC, (2005) HIV-1 tat protein and cell proliferation and survival: a brief review. New Microbiol 28: 95-109.
3. Peruzzi F, (2006) The multiple functions of HIV-1 Tat: proliferation versus apoptosis. Front Biosci 11: 708-717.
4. Bukrinsky M, (2006) SNFing HIV transcription. Retrovirology 3: 49.
5. Debaisieux S, Rayne F, Yezid H, Beaumelle B, (2012) The ins and outs of HIV-1 Tat. Traffic 13: 355-363.
6. Chen D, Wang M, Zhou S, Zhou Q, (2002) HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim. Embo J 21: 6801-6810.
7. Huo L, Li D, Sun L, Liu M, Shi X, et al. (2010) Tat acetylation regulates its actions on microtubule dynamics and apoptosis in T lymphocytes. J Pathol.
8. Romani B, Engelbrecht S, Glashoff RH, (2010) Functions of Tat: the versatile protein of human immunodeficiency virus type 1. J Gen Virol 91: 1-12.
9. Feng S, Holland EC, (1988) HIV-1 tat trans-activation requires the loop sequence within tar. Nature 334: 165-167.
10. Berkhout B, Jeang KT, (1989) trans activation of human immunodeficiency virus type 1 is sequence specific for both the single-stranded bulge and loop of the trans-acting-responsive hairpin: a quantitative analysis. J Virol 63: 5501-5504.
11. Wei P, Garber ME, Fang SM, Fischer WH, Jones KA, (1998) A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. Cell 92: 451-462.
12. Jeang KT, Berkhout B, Dropulic B, (1993) Effects of integration and replication on transcription of the HIV-1 long terminal repeat. J Biol Chem 268: 24940-24949.
13. Neuveut C, Jeang KT, (1996) Recombinant human immunodeficiency virus type 1 genomes with tat unconstrained by overlapping reading frames reveal residues in Tat important for replication in tissue culture. J Virol 70: 5572-5581.
14. Lopez-Huertas MR, Callejas S, Abia D, Mateos E, Dopazo A, et al. (2010) Modifications in host cell cytoskeleton structure and function mediated by intracellular HIV-1 Tat protein are greatly dependent on the second coding exon. Nucleic Acids Res 38: 3287-3307.
15. Hetzer C, Dormeyer W, Schnolzer M, Ott M, (2005) Decoding Tat: the biology of HIV Tat posttranslational modifications. Microbes Infect 7: 1364-1369.
16. Kiernan RE, Vanhulle C, Schiltz L, Adam E, Xiao H, et al. (1999) HIV-1 tat transcriptional activity is regulated by acetylation. EMBO J 18: 6106-6118.
17. Huo L, Li D, Sun X, Shi X, Karna P, et al. (2011) Regulation of Tat acetylation and transactivation activity by the microtubule-associated deacetylase HDAC6. J Biol Chem 286: 9280-9286.
18. D'Orso I, Frankel AD, (2009) Tat acetylation modulates assembly of a viral-host RNA-protein transcription complex. Proc Natl Acad Sci U S A 106: 3101-3106.
19. Ott M, Schnolzer M, Garnica J, Fischle W, Emiliani S, et al. (1999) Acetylation of the HIV-1 Tat protein by p300 is important for its transcriptional activity. Curr Biol 9: 1489-1492.
20. Deng L, de la Fuente C, Fu P, Wang L, Donnelly R, et al. (2000) Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones. Virology 277: 278-295.
21. Treand C, du Chene I, Bres V, Kiernan R, Benarous R, et al. (2006) Requirement for SWI/SNF chromatin-remodeling complex in Tat-mediated activation of the HIV-1 promoter. EMBO J 25: 1690-1699.
22. Mahmoudi T, Parra M, Vries RG, Kauder SE, Verrijzer CP, et al. (2006) The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter. J Biol Chem 281: 19960-19968.
23. Dorr A, Kiermer V, Pedal A, Rackwitz HR, Henklein P, et al. (2002) Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain. EMBO J 21: 2715-2723.
24. Col E, Caron C, Seigneurin-Berny D, Gracia J, Favier A, et al. (2001) The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat. J Biol Chem 276: 28179-28184.
25. Yang Y, Sun L, Tala, Gao J, Li D, et al. (2013) CYLD Regulates RhoA Activity by Modulating LARG Ubiquitination. PLoS One 8: e55833.
26. Stauber RH, Pavlakis GN, (1998) Intracellular trafficking and interactions of the HIV-1 Tat protein. Virology 252: 126-136.
27. Dormeyer W, Ott M, Schnolzer M, (2005) Probing lysine acetylation in proteins: strategies, limitations, and pitfalls of in vitro acetyltransferase assays. Mol Cell Proteomics 4: 1226-1239.
28. Yang XJ, Seto E, (2008) Lysine acetylation: codified crosstalk with other posttranslational modifications. Mol Cell 31: 449-461.
29. Truant R, Cullen BR, (1999) The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin beta-dependent nuclear localization signals. Mol Cell Biol 19: 1210-1217.
30. Cardarelli F, Serresi M, Bizzarri R, Beltram F, (2008) Tuning the transport properties of HIV-1 Tat arginine-rich motif in living cells. Traffic 9: 528-539.
31. Gautier VW, Sheehy N, Duffy M, Hashimoto K, Hall WW, (2005) Direct interaction of the human I-mfa domain-containing protein, HIC, with HIV-1 Tat results in cytoplasmic sequestration and control of Tat activity. Proc Natl Acad Sci U S A 102: 16362-16367.
32. Rappaport J, Lee SJ, Khalili K, Wong-Staal F, (1989) The acidic amino-terminal region of the HIV-1 Tat protein constitutes an essential activating domain. New Biol 1: 101-110.
33. Tiley LS, Brown PH, Cullen BR, (1990) Does the human immunodeficiency virus Tat trans-activator contain a discrete activation domain? Virology 178: 560-567.
34. Jordan MA, Wilson L, (2004) Microtubules as a target for anticancer drugs. Nat Rev Cancer 4: 253-265.