Bcl-2 correlates with localization but not outcome in human osteosarcoma

Oncology Letters

Volumn 6, Issue 2, 2013, Pages 559-561

  Trieb, Klemens ^a   Sulzbacher, Irene ^b   Kubista, Bernd ^c  

^a Klinikum Wels Grieskirchen GmbH   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY OF VIENNA   (Austria)

Author keywords

Bcl 2; Expression; Localization; Osteosarcoma; Outcome

Indexed keywords

CISPLATIN; DOXORUBICIN; IFOSFAMIDE; METHOTREXATE; PROTEIN BCL 2;

ADJUVANT CHEMOTHERAPY; ADOLESCENT; ADULT; ARTICLE; CANCER LOCALIZATION; CANCER PROGNOSIS; CANCER SURVIVAL; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; METASTASIS; OSTEOSARCOMA; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TUMOR BIOPSY; TUMOR CLASSIFICATION; TUMOR GROWTH; TUMOR VOLUME;

EID: 84879489706     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2013.1395     Document Type: Article

References (18)

1. Bielack S, Kempf-Bielack B, Delling G, Exner G, FlegeS, HelmkeK, Kotz R, Salzer-Kuntschik M, Werner M, WinkelmannW, Zoubek A, Jürgens H and Winkler K: Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols. J Clin Oncol 20: 776-790, 2002.
2. Davis AM, Bell RS and Goodwin PJ: Prognostic factors in osteosarcoma: a critical review. J Clin Oncol 12: 423-431, 1994.
3. Baldini N, Scotlandi K, Barbanti-Brodano G, ManaraM, MauriciD, Bacci G, Bertoni F, Picci P, Sottili S and CampanacciM: Expression of P-glycoprotein in high-grade osteosarcomas in relation to clinical outcome. N Engl J Med 333: 1380-1385, 1995.
4. Ferrari S, Bertoni F, Zanella L, Setola E, Bacchini P, AlberghiniM, Versari M and Bacci G: Evaluation of p-glycoprotein, HER2/ErbB-2, p53, and bcl-2 in primary tumor and metachronous lung metastases in patients with high-grade osteosarcoma. Cancer 100: 1936-1942, 2004.
5. Pakos E and Ioannidis J: The association of p-glycoprotein with response to chemotherapy and clinical outcome in patients with osteosarcoma. A meta-analysis. Cancer 98: 581-589, 2003.
6. Sulzbacher I, Birner P, Trieb K, Traxler M, Lang S and ChottA: Expression of platelet-derived growth factor-AA is associated with tumor progression in osteosarcoma. Mod Pathol 16: 66-71, 2003.
7. Trieb K and Kotz R: Proteins expressed in osteosarcoma and serum levels as prognostic factors. Int J Biochem Cell Biol 33: 11-17, 2001.
8. Chao D and Korsmeyer S: Bcl-2 family: regulators of cell death. Ann Rev Immunol 16: 395-419, 1998.
9. Jäättelä M: Escaping cell death: survival proteins in cancer. Exp Cell Res 248: 30-43, 1999.
10. Amling M, Pösl M, Bälser I and Delling G: Osteosarcoma-apoptosis and proliferation. Pathologe 15: 337-344, 1994 (InGerman).
11. Wang ZX, Yang JS, Pan X, Wang JR, Li J, Yin YM and DeW: Functional and biological analysis of Bcl-xL expression in human osteosarcoma. Bone 47: 445-454, 2010.
12. Wu X, Cai ZD, Lou LM and Zhu YB: Expression of p53, BCL-2, and apoptotic index in human osteosarcoma and their correlation with prognosis of patients. Cancer Epidemiol 36: 212-216, 2012.
13. Kaseta MK, Khaldi L, Gomatos IP, Tzagarakis GP, Alevizos L, Leandros E, Papagelopoulos PJ and Soucacos PN: Prognostic value of bax, cytochrome C, and caspase-8 protein expression in primary osteosarcoma. J Surg Oncol 97: 259-266, 2008.
14. Nedelcu T, Kubista B, Koller A, Sulzbacher I, Mosberger I, ArrichF, Trieb K, Kotz R and Toma CD: Livin and Bcl-2 expression in high-grade osteosarcoma. J Canc Res Clin Oncol 134: 237-244, 2008.
15. Enneking WF, Spanier SS and Goodman MA: A system for the surgical staging of musculoskeletal sarcoma. Clin Orthop 153: 106-120, 1980.
16. Salzer-Kuntschik M, Brand G and Delling G: Determination of the degree of morphological regression following chemotherapy in malignant bone tumors. Pathologe 4: 135-141, 1983 (InGerman).
17. Bankfalvi A, Navabi H, Bier P, Böcker W, Jansani B and SchmidK: Wet autoclave pretreatment for antigen retrieval in diagnostic immunohistochemistry. J Pathol 174: 223-229, 1994.
18. Kaplan E and Meier P: Nonparametic estimation from incomplete observations. J Am Stat Assoc 53: 457-461, 1958.