Transcranial laser therapy for acute ischemic stroke: A pooled analysis of NEST-1 and NEST-2

International Journal of Stroke

Volumn 8, Issue 5, 2013, Pages 315-320

  Huisa, Branko N ^a   Stemer, Andrew B ^b   Walker, Michael G ^c   Rapp, Karen ^b   Meyer, Brett C ^b   Zivin, Justin A ^b  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

Acute stroke; Clinical trial; Laser therapy; Neuroprotection; Stroke outcomes

Indexed keywords

ADULT; AGED; ARTICLE; BRAIN CORTEX; BRAIN ISCHEMIA; CLINICAL EFFECTIVENESS; COHORT ANALYSIS; FEMALE; HUMAN; LOW LEVEL LASER THERAPY; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RANKIN SCALE; TREATMENT RESPONSE;

ADULT; AGED; AGED, 80 AND OVER; BRAIN ISCHEMIA; FEMALE; FOLLOW-UP STUDIES; HUMANS; INTERNATIONAL COOPERATION; LASER THERAPY; MALE; MIDDLE AGED; OUTCOME ASSESSMENT (HEALTH CARE); SEVERITY OF ILLNESS INDEX; STROKE;

EID: 84879476953     PISSN: 17474930     EISSN: 17474949     Source Type: Journal    
DOI: 10.1111/j.1747-4949.2011.00754.x     Document Type: Article

References (17)

1. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995; 333 : 1581-1587.
2. Hacke W, Kaste M, Bluhmki E etal. Thrombolysis with alteplase 3 to 4.5hours after acute ischemic stroke. N Engl J Med 2008; 359 : 1317-1329.
3. Lloyd-Jones D, Adams RJ, Brown TM etal. Heart disease and stroke statistics - 2010 update: a report from the American Heart Association. Circulation 2010; 121 : e46-e215.
4. Kleindorfer D, Lindsell CJ, Brass L, Koroshetz W, Broderick JP. National US estimates of recombinant tissue plasminogen activator use: ICD-9 codes substantially underestimate. Stroke 2008; 39 : 924-928.
5. Ginsberg MD. Current status of neuroprotection for cerebral ischemia: synoptic overview. Stroke 2009; 40 : S111-114.
6. Stemer AB, Huisa BN, Zivin JA. The evolution of transcranial laser therapy for acute ischemic stroke, including a pooled analysis of NEST-1 and NEST-2. Curr Cardiol Rep 2010; 12 : 29-33.
7. Streeter J, De Taboada L, Oron U. Mechanisms of action of light therapy for stroke and acute myocardial infarction. Mitochondrion 2004; 4 : 569-576.
8. Leung MC, Lo SC, Siu FK, So KF. Treatment of experimentally induced transient cerebral ischemia with low energy laser inhibits nitric oxide synthase activity and up-regulates the expression of transforming growth factor-beta 1. Lasers Surg Med 2002; 31 : 283-288.
9. Oron A, Oron U, Chen J etal. Low-level laser therapy applied transcranially to rats after induction of stroke significantly reduces long-term neurological deficits. Stroke 2006; 37 : 2620-2624.
10. Rochkind S, El-Ani D, Nevo Z, Shahar A. Increase of neuronal sprouting and migration using 780nm laser phototherapy as procedure for cell therapy. Lasers Surg Med 2009; 41 : 277-281.
11. Detaboada L, Ilic S, Leichliter-Martha S, Oron U, Oron A, Streeter J. Transcranial application of low-energy laser irradiation improves neurological deficits in rats following acute stroke. Lasers Surg Med 2006; 38 : 70-73.
12. Lapchak PA, Wei J, Zivin JA. Transcranial infrared laser therapy improves clinical rating scores after embolic strokes in rabbits. Stroke 2004; 35 : 1985-1988.
13. Lapchak PA, Maher P, Schubert D, Zivin JA. Baicalein, an antioxidant 12/15-lipoxygenase inhibitor improves clinical rating scores following multiple infarct embolic strokes. Neuroscience 2007; 150 : 585-591.
14. Lampl Y, Zivin JA, Fisher M etal. Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1). Stroke 2007; 38 : 1843-1849.
15. Zivin JA, Albers GW, Bornstein N etal. Effectiveness and safety of transcranial laser therapy for acute ischemic stroke. Stroke 2009; 40 : 1359-1364.
16. Kent DM, Selker HP, Ruthazer R, Bluhmki E, Hacke W. The stroke-thrombolytic predictive instrument: a predictive instrument for intravenous thrombolysis in acute ischemic stroke. Stroke 2006; 37 : 2957-2962.
17. Lapchak PA, Han MK, Salgado KF, Streeter J, Zivin JA. Safety profile of transcranial near-infrared laser therapy administered in combination with thrombolytic therapy to embolized rabbits. Stroke 2008; 39 : 3073-3078.