A Proline/Arginine-Rich End Leucine-Rich Repeat Protein (PRELP) Variant Is Uniquely Expressed in Chronic Lymphocytic Leukemia Cells

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Mikaelsson, Eva ^a   Österborg, Anders ^a,b   Jeddi Tehrani, Mahmood ^a,c   Kokhaei, Parviz ^a,d   Ostadkarampour, Mahyar ^c   Hadavi, Reza ^c   Gholamin, Mehran ^e   Akhondi, Mehdi ^c   Shokri, Fazel ^c,f   Rabbani, Hodjattallah ^c   Mellstedt, Håkan ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c AVICENNA RESEARCH INSTITUTE   (Iran)

^d SEMNAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^f TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

CORE PROTEIN; PROLINE ARGININE RICH END LEUCINE RICH REPEAT PROTEIN; PROTEIN VARIANT; PROTEOGLYCAN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; DEGLYCOSYLATION; FEMALE; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MAJOR CLINICAL STUDY; MALE; MOLECULAR PATHOLOGY; MOLECULAR WEIGHT; PROLINE ARGININE RICH END LEUCINE RICH REPEAT GENE; PROTEIN EXPRESSION;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODY SPECIFICITY; BLOTTING, WESTERN; CASE-CONTROL STUDIES; CELL LINE, TUMOR; EXTRACELLULAR MATRIX PROTEINS; FEMALE; GENE EXPRESSION REGULATION, LEUKEMIC; GLYCOPROTEINS; GLYCOSYLATION; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; PROTEIN ISOFORMS; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84879472522     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067601     Document Type: Article

References (18)

1. Klein U, Tu Y, Stolovitzky GA, Mattioli M, Cattoretti G, et al. (2001) Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells. J Exp Med 194: 1625-1638.
2. Mikaelsson E, Danesh-Manesh AH, Luppert A, Jeddi-Tehrani M, Rezvany MR, et al. (2005) Fibromodulin, an extracellular matrix protein: characterization of its unique gene and protein expression in B-cell chronic lymphocytic leukemia and mantle cell lymphoma. Blood 105: 4828-4835.
3. Sztrolovics R, Chen XN, Grover J, Roughley PJ, Korenberg JR, (1994) Localization of the human fibromodulin gene (FMOD) to chromosome 1q32 and completion of the cDNA sequence. Genomics 23: 715-717.
4. Grover J, Chen XN, Korenberg JR, Recklies AD, Roughley PJ, (1996) The gene organization, chromosome location, and expression of a 55-kDa matrix protein (PRELP) of human articular cartilage. Genomics 38: 109-117.
5. Bengtsson E, Neame PJ, Heinegard D, Sommarin Y, (1995) The primary structure of a basic leucine-rich repeat protein, PRELP, found in connective tissues. J Biol Chem 270: 25639-25644.
6. Bengtsson E, Aspberg A, Heinegard D, Sommarin Y, Spillmann D, (2000) The amino-terminal part of PRELP binds to heparin and heparan sulfate. J Biol Chem 275: 40695-40702.
7. Bengtsson E, Morgelin M, Sasaki T, Timpl R, Heinegard D, et al. (2002) The leucine-rich repeat protein PRELP binds perlecan and collagens and may function as a basement membrane anchor. J Biol Chem 277: 15061-15068.
8. Daneshmanesh AH, Mikaelsson E, Jeddi-Tehrani M, Bayat AA, Ghods R, et al. (2008) Ror1, a cell surface receptor tyrosine kinase is expressed in chronic lymphocytic leukemia and may serve as a putative target for therapy. Int J Cancer 123: 1190-1195.
9. Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, et al. (2000) The World Health Organization classification of neoplastic diseases of the haematopoietic and lymphoid tissues: Report of the Clinical Advisory Committee Meeting, Airlie House, Virginia, November 1997. Histopathology 36: 69-86.
10. Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, et al. (2008) Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood 111: 5446-5456.
11. Drexler HG (2001) The Leukemia-Lymphoma Cell Line FactsBook. San Diego: Academic Press.
12. Wendel-Hansen V, Sallstrom J, De Campos-Lima PO, Kjellstrom G, Sandlund A, et al. (1994) Epstein-Barr virus (EBV) can immortalize B-cll cells activated by cytokines. Leukemia 8: 476-484.
13. Edge AS, (2003) Deglycosylation of glycoproteins with trifluoromethanesulphonic acid: elucidation of molecular structure and function. Biochem J 376: 339-350.
14. Kohler G, Milstein C, (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256: 495-497.
15. Ferreira A, Busciglio J, Caceres A, (1989) Microtubule formation and neurite growth in cerebellar macroneurons which develop in vitro: evidence for the involvement of the microtubule-associated proteins, MAP-1a, HMW-MAP2 and Tau. Brain Res Dev Brain Res 49: 215-228.
16. Lu YP, Ishiwata T, Kawahara K, Watanabe M, Naito Z, et al. (2002) Expression of lumican in human colorectal cancer cells. Pathol Int 52: 519-526.
17. McDoniels-Silvers AL, Nimri CF, Stoner GD, Lubet RA, You M, (2002) Differential gene expression in human lung adenocarcinomas and squamous cell carcinomas. Clin Cancer Res 8: 1127-1138.
18. Rufo A AM, Rucci N, Capulli M, Heinegard D, Teti A (2008) The matrix PROLINE/Arginine-Rich End Leucin-Rich Repeat Protein (PRELP) impairs osteoclastogenesis by inhibiting NF-kappaB activity. Bone 42: S39-S40 Abstract 52.