Intravenously injected recombinant human type VII collagen homes to skin wounds and restores skin integrity of dystrophic epidermolysis bullosa

Journal of Investigative Dermatology

Volumn 133, Issue 7, 2013, Pages 1910-1913

  Woodley, David T ^a   Wang, Xinyi ^a   Amir, Mahsa ^a   Hwang, Brian ^a   Remington, Jennifer ^a   Hou, Yingpin ^a   Uitto, Jouni ^b   Keene, Douglas ^c   Chen, Mei ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c SHRINERS HOSPITAL FOR CHILDREN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 7;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; COL7A1 GENE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE INCREASE; EPIDERMOLYSIS BULLOSA DYSTROPHICA; GENE; GENE EXPRESSION; IMMUNOELECTRON MICROSCOPY; IMMUNOFLUORESCENCE; LETTER; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; SKIN GRAFT; SKIN INJURY; SKIN TRANSPLANTATION;

EID: 84879412500     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2013.10     Document Type: Letter

References (16)

1. Burgeson RE (1993) Type VII collagen, anchoring fibrils, and epidermolysis bullosa. J Invest Dermatol 101:252-5 (Pubitemid 23269892)
2. Chen M, Kasahara N, Keene DR et al. (2002) Restoration of type VII collagen expression and function in dystrophic epidermolysis bul-losa. Nat Genet 32:670-5 (Pubitemid 35435183)
3. Christiano AM, Greenspan DS, Lee S et al. (1994) Cloning of human type VII collagen: complete primary sequence of the a1(VIII) chain and identification of intragenic polymorphisms. J Biol Chem 269:20256-62
4. Fine JD, Eady RA, Bauer EA et al. (2008) The classification of inherited epidermolysis bullosa (EB): report of the Third International Consensus Meeting on Diagnosis and Classification of EB. J Am Acad Dermatol 58:931-50
5. Heinonen S, Männikkö M, Klement JF et al. (1999) Targeted inactivation of the type VII collagen gene (Col7a1) in mice results in severe blistering phenotype: a model for recessive dystrophic epidermolysis bullosa. J Cell Sci 112:3641-8
6. Ortiz-Urda S, Lin Q, Green CL et al. (2003) Injection of genetically engineered fibro-blasts corrects regenerated human epidermo-lysis bullosa skin tissue. J Clin Invest 111: 251-5 (Pubitemid 36105924)
7. Ortiz-Urda S, Thyagarajan B, Keene DR et al. (2002) Stable nonviral genetic correction of inherited human skin disease. Nat Med 8:1166-70 (Pubitemid 35175973)
8. Remington J, Wang X, Hou Y et al. (2009) Injection of recombinant human type VII collagen corrects the disease phenotype in a murine model of dystrophic epidermolysis bullosa. Mol Ther 17:26-33
9. Saelman EU, Nieuwenhuis HK, Hese KM et al. (1994) Platelet adhesion to collagen types I through VIII under conditions of stasis and flow is mediated by GPIa/IIa (alpha 2 beta 1-integrin). Blood 83:1244-50 (Pubitemid 24062847)
10. Sakai LY, Keene DR (1994) Fibrillin: monomers and microfibrils. In: Ruoslahti E, Engvall E (eds). Methods in Enzymology volume 245. Academic Press: San Diego, CA, pp 47-50
11. Sakai LY, Keene DR, Morris NP et al. (1986) Type VII collagen is a major structural component of anchoring fibrils. J Cell Biol 103: 1577-86 (Pubitemid 17174180)
12. Wagner JE, Ishida-Yamamoto A, McGrath JA et al. (2010) Bone marrow transplantation for recessive dystrophic epidermolysis bullosa. N Engl J Med 363:629-39
13. Wong T, Gammon L, Liu L et al. (2008) Potential of fibroblast cell therapy for recessive dystrophic epidermolysis bullosa. J Invest Dermatol 128:2179-89
14. Woodley DT, Keene DR, Atha T et al. (2004) Injection of recombinant human type VII collagen restores collagen function in dystrophic epidermolysis bullosa. Nat Med 10:693-5 (Pubitemid 38937633)
15. Woodley DT, Keene DR, Atha T et al. (2004) Intradermal injection of lentiviral vectors corrects regenerated human dystrophic epider-molysis bullosa skin tissue in vivo. Mol Ther 10:318-26 (Pubitemid 39117876)
16. Woodley DT, Krueger GG, Jorgensen CM et al. (2003) Normal and gene-corrected dystrophic epidermolysis bullosa fibroblasts alone can produce type VII collagen at the basement membrane zone. J Invest Dermatol 121: 1021-8 (Pubitemid 37430968)