Evidence for central sensitization in chronic whiplash: A systematic literature review

European Journal of Pain (United Kingdom)

Volumn 17, Issue 3, 2013, Pages 299-312

  Van Oosterwijck, J ^a,b,c   Nijs, J ^a,b,c   Meeus, M ^a,b   Paul, L ^d  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b Hogeschool Antwerpen   (Belgium)

^c UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALLODYNIA; CENTRAL NERVOUS SYSTEM; CHRONIC DISEASE; DIFFUSE NOXIOUS INHIBITORY CONTROL; ELECTROSTIMULATION; HUMAN; HYPERALGESIA; HYPERSENSITIVITY; INFORMATION PROCESSING; MECHANICAL STIMULATION; NECK PAIN; NERVOUS TISSUE; PAIN THRESHOLD; PRIORITY JOURNAL; REFERRED PAIN; REVIEW; SEARCH ENGINE; SENSITIZATION; SKIN STIMULATION; SPINAL REFLEX; SYMPATHETIC REFLEX; SYSTEMATIC REVIEW; TEMPORAL SUMMATION; THERMAL STIMULATION; THORAX PAIN; VASOCONSTRICTION; WHIPLASH INJURY;

ANESTHETICS, LOCAL; CASE-CONTROL STUDIES; CENTRAL NERVOUS SYSTEM SENSITIZATION; CHRONIC DISEASE; CLINICAL TRIALS AS TOPIC; HUMANS; HYPERALGESIA; PAIN; PAIN MEASUREMENT; PHYSICAL STIMULATION; RANDOMIZED CONTROLLED TRIALS AS TOPIC; REFLEX; RESEARCH DESIGN; WHIPLASH INJURIES;

EID: 84879393920     PISSN: 10903801     EISSN: 15322149     Source Type: Journal    
DOI: 10.1002/j.1532-2149.2012.00193.x     Document Type: Review

References (63)

1. Banic, B., Petersen-Felix, S., Andersen, O.K., Radanov, B.P., Villiger, P.M., Arendt-Nielsen, L., Curatolo, M. (2004). Evidence for spinal cord hypersensitivity in chronic pain after whiplash injury and in fibromyalgia. Pain 107(1-2), 7-15. http://dx.doi.org/10.1016/j.pain.2003.05.001.
2. Bock, S.L., Centeno, C.J., Elliott, J.M. (2005). The presence and interrater reliability of thoracic allodynia in a whiplash cohort. Pain Physician 8(3), 267-270.
3. Carroll, L.J., Holm, L.W., Hogg-Johnson, S., Côté, P., Cassidy, J.D., Haldeman, S., Nordin, M., Hurwitz, E.L., Carragee, E.J., van der Velde, G., Peloso, P.M., Guzman, J. (2008). Course and prognostic factors for neck pain in whiplash-associated disorders (WAD): Results of the bone and joint decade 2000-2010 task force on neck pain and its associated disorders. Spine 15, 33(4 Suppl), S93-100. http://dx.doi.org/10.1097%2FBRS. 0b013e31816445d4.
4. Chien, A., Eliav, E., Sterling, M. (2008). Whiplash (grade II) and cervical radiculopathy share a similar sensory presentation: An investigation using quantitative sensory testing. Clin J Pain 24(7), 595-603. http://dx.doi.org/10.1097/AJP. 0b013e31816ed4fc.
5. Chien, A., Eliav, E., Sterling, M. (2009). Hypoaesthesia occurs with sensory hypersensitivity in chronic whiplash - further evidence of a neuropathic condition. Man Ther 14(2), 138-146. http://dx.doi.org/10.1016%2Fj.math.2007.12. 004.
6. Chien, A., Eliav, E., Sterling, M. (2010). The development of sensory hypoesthesia after whiplash injury. Clin J Pain 26(8), 722-728. http://dx.doi.org/10.1097%2FAJP. 0b013e3181f096ac.
7. Coderre, T.J., Katz, J., Vaccarino, A.L., Melzack, R. (1993). Contribution of central neuroplasticity to pathological pain: Review of clinical and experimental evidence. Pain 52, 259-285. http://dx.doi.org/10.1016/0304- 3959(93)90161-H.
8. Curatolo, M., Petersen-Felix, S., Arendt-Nielsen, L., Giani, C., Zbinden, A.M., Radanov, B.P. (2001). Central hypersensitivity in chronic pain after whiplash injury. Clin J Pain 17(4), 306-315. http://dx.doi.org/10.1097/00002508- 200112000-00004.
9. Davis, C. (2001). Chronic pain/dysfunction in whiplashassociated disorders. J Manipulative Physiol Ther 24(1), 44-51. http://dx.doi.org/10.1067/ mmt.2001.112012.
10. Desmeules, J.A., Cedraschi, C., Rapiti, E., Baumgartner, E., Finckh, A., Cohen, P., Dayer, P., Vischer, T.L. (2003). Neurophysiologic evidence for a central sensitization in patients with fibromyalgia. Arthritis Rheum 48(5), 1420-1429. http://dx.doi.org/10.1002%2Fart.10893.
11. Ferrari, R. (2010). Predicting central sensitisation - Whiplash patients. Aust Fam Physician 39(11), 863-866.
12. Fischer, A.A., Russell, I.J. (1998). Muscle Pain Syndromes and Fibromyalgia: Pressure Algometry for Quantification of Diagnosis and Treatment Outcome, A.A. Fischer ed. (New York: The Haworth Medical Press). 158p.
13. Gerdle, B., Lemming, D., Kristiansen, J., Larsson, B., Peolsson, M., Rosendal, L. (2008). Biochemical alterations in the trapezius muscle of patients with chronic whiplash associated disorders (WAD) - A microdialysis study. Eur J Pain 12(1), 82-93.
14. Graven-Nielsen, T., Arendt-Nielsen, L. (2002). Peripheral and central sensitization in musculoskeletal pain disorders: An experimental approach. Curr Rheumatol Rep 4, 313-321. http://dx.doi.org/10.1007/s11926-002-0040-y.
15. Graven-Nielsen, T., Arendt-Nielsen, L. (2008). Human models and clinical manifestations of musculoskeletal pain and painmotor interactions. In Fundamentals of Musculoskeletal Pain, T. Graven-Nielsen, L. Arendt-Nielsen, S. Mense, eds. (Seattle, WA: IASP Press) pp. 155-187.
16. Greening, J., Lynn, B., Leary, R. (2003). Sensory and autonomic function in the hands of patients with non-specific arm pain (NSAP) and asymptomatic office workers. Pain 104, 275-281. http://dx.doi.org/10.1016/S0304-3959(03) 00010-1.
17. Gunn, C.C., Byrne, D., Goldberger, M., Lam, A., Leung, M.K., McBrinn, J., Nixon, A., Wong, K. (2001). Treating whiplashassociated disorders with intramuscular stimulation: A retrospective review of 43 patients with long-term follow-up. J Musculoskel Pain 9(2), 69-90. http://dx.doi.org/10. 1300%2FJ094v09n02-06.
18. Handwerker, H.O., Kobal, G. (1993). Psychophysiology of experimentally induced pain. Physiol Rev 73, 639-671.
19. Herren-Gerber, R., Weiss, S., Arendt-Nielsen, L., Petersen-Felix, S., Di Stefano, G., Radanov, B.P., Curatolo, M. (2004). Modulation of central hypersensitivity by nociceptive input in chronic pain after whiplash injury. Pain Med 5, 366-376. http://dx.doi.org/10.1111/j.1526-4637.2004.04055.x.
20. Ide, M., Ide, J., Yamaga, M., Takagi, K. (2001). Symptoms and signs of irritation of the brachial plexus in whiplash injuries. J Bone Joint Surg 83, 226-229. http://dx.doi.org/10.1302/0301-620X.83B2.11094.
21. Jull, G., Sterling, M., Kenardy, J., Beller, E. (2007). Does the presence of sensory hypersensitivity influence outcomes of physical rehabilitation for chronic whiplash? A preliminary RCT. Pain 129, 28-34. http://dx.doi.org/10. 1016%2Fj.pain. 2006.09.030.
22. Kamper, S.J., Maher, C.G., Hush, J.M., Pedler, A., Sterling, M. (2011). Relationship between pressure pain thresholds and pain ratings in patients with whiplash-associated disorders. Clin J Pain 27(6), 495-501. http://dx.doi.org/10. 1097%2FAJP. 0b013e31820e1185.
23. Kamper, S.J., Rebbeck, T.J., Maher, C.G., McAuley, J.H., Sterling, M. (2008). Course and prognostic factors of whiplash: A systematic review and meta-analysis. Pain, 138(3), 617-629. http://dx.doi.org/10.1016%2Fj.pain.2008. 02.019.
24. Kasch, H., Qerama, E., Bach, F.W., Jensen, T.S. (2005). Reduced cold pressor pain tolerance in non-recovered whiplash patients: A 1-year prospective study. Eur J Pain 9(5), 561-569. http://dx.doi.org/10.1016/j.ejpain.2004.11.011.
25. Kasch, H., Stengaard-Pedersen, K., Arendt-Nielsen, L., Staehelin Jensen, T. (2001). Pain thresholds and tenderness in neck and head following acute whiplash injury: A prospective study. Cephalalgia 21(3), 189-197. http://dx.doi.org/10.1046/j.1468-2982.2001.00179.x.
26. Kosek, E., Januszewska, A. (2008). Mechanisms of pain referral in patients with whiplash-associated disorder. Eur J Pain 12(5), 650-660. http://dx.doi.org/10.1016/j.ejpain.2007.10.006.
27. Lemming, D., Sörensen, J., Graven-Nielsen, T., Arendt-Nielsen, L., Gerdle, B. (2005). The responses to pharmacological challenges and experimental pain in patients with chronic whiplash-associated pain. Clin J Pain 21(5), 412-421. http://dx.doi.org/10.1097/01.ajp.0000126155.82815.fc.
28. Liberati, A., Altman, D.G., Tetzlaff, J., Mulrow, C., Gøtzsche, P.C., Ioannidis, J.P.A., Clarke, M., Devereaux, P.J., Kleijnen, J., Moher, D. (2009). The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. PLoS Med 6(7), e1000100. http://dx.doi.org/10.1371%2Fjournal. pmed.1000100.
29. Meeus, M., Nijs, J. (2007). Central sensitization: A biopsychosocial explanation for chronic widespread pain in patients with fibromyalgia and chronic fatigue syndrome. Clin Rheumatol 26, 465-473. http://dx.doi.org/10. 1007%2Fs10067-006-0433-9.
30. Meeus, M., Nijs, J., Van De Wauwer, N., Toeback, L., Truijen, S. (2008). Diffuse noxious inhibitory control is delayed in chronic fatigue syndrome: An experimental study. Pain 139, 439-448. http://dx.doi.org/10.1016%2Fj.pain.2008. 05.018.
31. Mendell, L.M. (1966). Physiological properties of unmyelinated fibre projection to the spinal cord. Exp Neurol 16, 316-332.
32. Mendell, L.M., Wall, P.D. (1965). Responses of single dorsal cord cells to peripheral cutaneous unmyelinated fibres. Nature 206, 97-99.
33. Merskey, H., Bogduk, N. (1994). IASP Task Force on Taxonomy, Part III: Pain terms, a current list with definitions and notes on usage. In Classification of Chronic Pain, 2nd edn, H. Merskey, N. Bogduk, eds. (Seattle, WA: IASP Press) pp. 209-214.
34. Morris, V.H., Cruwys, S.C., Kidd, B.L. (1997). Characterisation of capsaicin-induced mechanical hyperalgesia as a marker for altered nociceptive processing in patients with rheumatoid arthritis. Pain 71, 179-186. http://dx.doi.org/10.1016%2FS0304-3959%2897%2903361-7.
35. National Pharmaceutical Council (NPC) and Joint Commission on Accreditation of Healthcare Organizations (JCAHO). Pain: Current understanding of assessment, managements and treatment. 2001. http://www.npcnow.org/App- Themes/Public/pdf/Issues/pub-related-research/pub-quality-care/ Pain-Current-Understanding-of-Assessment-Managementand-Treatments.pdf.
36. Neziri, A.Y., Andersen, O.K., Petersen-Felix, S., Radanov, B., Dickenson, A.H., Scaramozzino, P., Arendt-Nielsen, L., Curatolo, M. (2010). The nociceptive withdrawal reflex: Normative values of thresholds and reflex receptive fields. Eur J Pain 14, 134-141. http://dx.doi.org/10.1016%2Fj.ejpain. 2009.04.010.
37. Neziri, A.Y., Scaramozzino, P., Andersen, O.K., Dickenson, A.H., Arendt Nielsen, L., Curatolo, M. (2011). Reference values of mechanical and thermal pain tests in a pain-free population. Eur J Pain 15, 376-383. http://dx.doi.org/10.1016%2Fj. ejpain.2010.08.011.
38. Nijs, J., Van Houdenhove, B., Oostendorp, R.A.B. (2010). Recognition of central sensitization in patients with musculoskeletal pain: Application of pain neurophysiology in manual therapy practice. Man Ther 15, 135-141. http://dx.doi.org/10.1016%2Fj.math.2009.12.001.
39. Nijs, J., Van Oosterwijck, J., De Hertogh, W. (2009). Rehabilitation of chronic whiplash: Treatment of cervical dysfunctions or chronic pain syndrome? Clin Rheumatol 28, 243-251. http://dx.doi.org/10.1007%2Fs10067-008-1083-x.
40. Price, D.D. (1972). Characteristics of second pain and flexion reflexes indicative of prolonged central summation. Exp Neurol 37, 371-387. http://dx.doi.org/10.1016%2F0014-4886%2872%2990081-7.
41. Raak, R., Wallin, M. (2006). Thermal thresholds and catastrophizing in individuals with chronic pain after whiplash injury. Biol Res Nurs 8(2), 138-146. http://dx.doi.org/10.1177/1099800406291078.
42. Rhudy, J.L., Meagher, M.W. (2000). Fear and anxiety: Divergent effects on human pain thresholds. Pain 84, 65-75. http://dx.doi.org/10.1016/S0304-3959(99) 00183-9.
43. Rolke, R., Baron, R., Maier, C., Tolle, T.R., Treede, R.D., Beyer, A., Binder, A., Birbaumer, N., Birklein, F., Botefur, I.C., Braune, S., Flor, H., Huge, V., Klug, R., Landwehrmeyer, G.B., Magerl, W., Maihofner, C., Rolko, C., Schaub, C., Scherens, A., Sprenger, T., Valet, M., Wasserka, B. (2006). Quantitative sensory testing in the German research network on neuropathic pain (DFNS): Standardized protocol and reference values. Pain 123, 231-243. http://dx.doi.org/10.1016%2Fj. pain.2006.01.041.
44. Schneider, G.M., Smith, A.D., Hooper, A., Stratford, P., Schneider, K.J., Westaway, M.D., Frizzell, B., Olson, L. (2010). Minimizing the source of nociception and its concurrent effect on sensory hypersensitivity: An exploratory study in chronic whiplash patients. BMC Musculoskelet Disord 11, 29. http://dx.doi.org/10.1186%2F1471-2474-11-29.
45. Scott, D., Jull, G., Sterling, M. (2005). Widespread sensory hypersensitivity is a feature of chronic whiplash-associated disorder but not chronic idiopathic neck pain. Clin J Pain 21(2), 175-181. http://dx.doi.org/10. 1097%2F00002508-200503000-00009.
46. Spitzer, W.O., Skovron, M.L., Salmi, L.R., Cassidy, J.D., Duranceau, J., Suissa, S., Zeiss, E. (1995). Scientific monograph of the Quebec task force on whiplash-associated disorders: Redefining 'whiplash' and its management. Spine 20(8 Suppl), 1S-73S. http://www.ncbi.nlm.nih.gov/pubmed/7604354.
47. Staud, R., Craggs, J.G., Robinson, M.E., Perlstein, W.M., Price, D.D. (2007). Brain activity related to temporal summation of C-fiber evoked pain. Pain 129, 130-142. http://dx.doi.org/10.1016%2Fj.pain.2006.10.010.
48. Staud, R., Smitherman, M.L. (2002). Peripheral and central sensitization in fibromyalgia: Pathogenic role. Curr Pain Headache Rep 6, 259-266. http://dx.doi.org/10.1007/s11916-002-0046-1.
49. Sterling, M. (2010). Differential development of sensory hypersensitivity and a measure of spinal cord hyperexcitability following whiplash injury. Pain 150(3), 501-506. http://dx.doi.org/10.1016%2Fj.pain.2010.06.003.
50. Sterling, M., Hodkinson, E., Pettiford, C., Souvlis, T., Curatolo, M. (2008). Psychologic factors are related to some sensory pain thresholds but not nociceptive flexion reflex threshold in chronic whiplash. Clin J Pain 24(2), 124-130. http://dx.doi.org/10.1097/AJP.0b013e31815ca293.
51. Sterling, M., Jull, G., Vicenzino, B., Kenardy, J. (2003). Sensory hypersensitivity occurs soon after whiplash injury and is associated with poor recovery. Pain 104, 509-517. http://dx.doi.org/10.1016/S0304-3959%2803%2900078- 2.
52. Sterling, M., Pedler, A., Chan, C., Puglisi, M., Vuvan, V., Vicenzino, B. (2010). Cervical lateral glide increases nociceptive flexion reflex threshold but not pressure or thermal pain thresholds in chronic whiplash associated disorders: A pilot randomised controlled trial. Man Ther 15(2), 149-153. http://dx.doi.org/10.1016%2Fj.math.2009.09.004.
53. Sterling, M., Treleaven, J., Edwards, S., Jull, G. (2002a). Pressure pain thresholds in chronic whiplash associated disorder: Further evidence of altered central pain processing. J Musculoskel Pain 10, 69-81. http://dx.doi.org/10. 1300/J094v10n03-05.
54. Sterling, M., Treleaven, J., Jull, G. (2002b). Responses to a clinical test of mechanical provocation of nerve tissue in whiplash associated disorder. Man Ther 7(2), 89-94. http://dx.doi.org/10.1054%2Fmath.2002.0443.
55. Thunberg, J., Hellström, F., Sjölander, P., Bergenheim, M., Wenngren, B., Johansson, H. (2001). Influences on the fusimotormuscle spindle system from chemosensitive nerve endings in cervical facet joints in the cat: Possible implications for whiplash induced disorders. Pain 91, 15-22. http://dx.doi.org/10.1016%2FS0304-3959%2800%2900415-2.
56. Wallin, M., Liedberg, G., Börsbo, B., Gerdle, B. (2012). Thermal detection and pain thresholds but not pressure pain thresholds are correlated with psychological factors in women with chronic whiplash-associated pain. Clin J Pain 28(3), 211-221. http://dx.doi.org/10.1097%2FAJP.0b013e318226c3fd.
57. Wolfe, F., Clauw, D.J., Fitzcharles, M.A., Goldenberg, D.L., Katz, R.S., Mease, P., Russell, A.S., Russell, I.J., Winfield, J.B., Yunus, M.B. (2010). The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res 62(5), 600-610. http://dx.doi.org/10.1002/acr.20140.
58. Wolfe, F., Smythe, H.A., Yunus, M.B., Bennett, R.M., Bombardier, C., Goldenberg, D.L., Tugwell, P., Campbell, S.M., Abeles, M., Clark, P., Fam, A.G., Farber, S.J., Fiechtner, J.J., Franklin, C.M., Gatter, R.A., Hamaty, D., Lessard, J., Lichtbroun, A.S., Masi, A.T., McCain, G.A., Reynolds, W.J., Romano, T.J., Russell, I.J., Sheon, R.P. (1990). The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Report of the multicenter criteria committee. Arthritis Rheum 33, 160-172.
59. Woolf, C.J. (1983). Evidence for a central component of postinjury pain hypersensitivity. Nature 306, 686-688. http://dx.doi.org/10.1038%2F306686a0.
60. Woolf, C.J. (2011). Central sensitization: Implications for the diagnosis and treatment of pain. Pain 152, S2-15. http://dx.doi.org/10.1002%2Fart. 1780330203.
61. Woolf, C.J., Doubell, T.P. (1994). The pathophysiology of chronic pain - Increased sensitivity to low threshold A β-fibre inputs. Curr Opin Neurobiom 4, 525-534. http://dx.doi.org/10.1016%2F0959-4388%2894%2990053-1.
62. Zhuo, M. (2007). A synaptic model for pain: Long-term potentiation in the anterior cingulate cortex. Mol Cells 23, 259-271.
63. Zusman, M. (2002). Forebrain-mediated sensitization of central pain pathways: 'Non-specific' pain and a new image for MT. Man Ther 7, 80-88. http://dx.doi.org/10.1054/math.2002. 0442.