메뉴 건너뛰기




Volumn 6, Issue 4, 2013, Pages 776-786

The adult penile urethra is a novel entry site for HIV-1 that preferentially targets resident urethral macrophages

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; GAMMA INTERFERON; GLYCOPROTEIN GP 41; IMMUNOGLOBULIN A; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 22; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 9; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; TUMOR NECROSIS FACTOR ALPHA;

EID: 84879359848     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2012.116     Document Type: Article
Times cited : (73)

References (39)
  • 1
    • 44349159423 scopus 로고    scopus 로고
    • Setting the stage: Host invasion by HIV
    • Hladik, F. & McElrath, M.J. Setting the stage: host invasion by HIV. Nat Rev Immunol 8, 447-457 (2008).
    • (2008) Nat Rev Immunol , vol.8 , pp. 447-457
    • Hladik, F.1    McElrath, M.J.2
  • 2
    • 28444460441 scopus 로고    scopus 로고
    • Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: The ANRS 1265 Trial
    • Auvert, B. et al. Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: the ANRS 1265 Trial. PLoS Med 2, e298 (2005).
    • (2005) PLoS Med , vol.2
    • Auvert, B.1
  • 3
    • 33847151707 scopus 로고    scopus 로고
    • Male circumcision for HIV prevention in young men in Kisumu Kenya:arandomised controlledtrial
    • Bailey, R.C. et al. Male circumcision for HIV prevention in young men in Kisumu, Kenya:arandomised controlledtrial. Lancet369, 643-656 (2007).
    • (2007) Lancet , vol.369 , pp. 643-656
    • Bailey, R.C.1
  • 4
    • 33847104829 scopus 로고    scopus 로고
    • Male circumcision for HIV prevention in men in Rakai, Uganda: A randomised trial
    • Gray, R.H. et al. Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial. Lancet 369, 657-666 (2007).
    • (2007) Lancet , vol.369 , pp. 657-666
    • Gray, R.H.1
  • 5
    • 77955884322 scopus 로고    scopus 로고
    • Within 1 h, HIV-1 uses viral synapses to enter efficiently the inner, but not outer, foreskin mucosa and engages Langerhans-T cell conjugates
    • Ganor, Y. et al. Within 1 h, HIV-1 uses viral synapses to enter efficiently the inner, but not outer, foreskin mucosa and engages Langerhans-T cell conjugates. Mucosal Immunol 3, 506-522 (2010).
    • (2010) Mucosal Immunol , vol.3 , pp. 506-522
    • Ganor, Y.1
  • 6
    • 79551642339 scopus 로고    scopus 로고
    • HIV-1 transmission in the male genital tract
    • Ganor, Y. & Bomsel, M. HIV-1 transmission in the male genital tract. Am J Reprod Immunol 65, 284-291 (2011).
    • (2011) Am J Reprod Immunol , vol.65 , pp. 284-291
    • Ganor, Y.1    Bomsel, M.2
  • 7
    • 79959822361 scopus 로고    scopus 로고
    • HIV-1 efficient entry in inner foreskin is mediated by elevated CCL5/RANTES that recruits T cells and fuels conjugate formation with langerhans cells
    • Zhou, Z. et al. HIV-1 efficient entry in inner foreskin is mediated by elevated CCL5/RANTES that recruits T cells and fuels conjugate formation with langerhans cells. PLoS Pathog 7, e1002100 (2011).
    • (2011) PLoS Pathog , vol.7
    • Zhou, Z.1
  • 9
    • 0028998728 scopus 로고
    • Immunobiology of the human penile urethra
    • Pudney, J. & Anderson, D.J. Immunobiology of the human penile urethra. Am J Pathol 147, 155-165 (1995).
    • (1995) Am J Pathol , vol.147 , pp. 155-165
    • Pudney, J.1    Anderson, D.J.2
  • 10
  • 11
    • 79952699152 scopus 로고    scopus 로고
    • Innate and acquired immunity in the human penile urethra
    • Pudney, J. & Anderson, D. Innate and acquired immunity in the human penile urethra. J Reprod Immunol 88, 219-227 (2011).
    • (2011) J Reprod Immunol , vol.88 , pp. 219-227
    • Pudney, J.1    Anderson, D.2
  • 12
    • 77952709256 scopus 로고    scopus 로고
    • Prevalence of human papillomavirus infection in the urinary tract of men with urethritis
    • Shigehara, K. et al. Prevalence of human papillomavirus infection in the urinary tract of men with urethritis. Int J Urol 17, 563-568 (2010).
    • (2010) Int J Urol , vol.17 , pp. 563-568
    • Shigehara, K.1
  • 13
    • 0347927725 scopus 로고    scopus 로고
    • Agents of non-gonococcal urethritis in males attending an Israeli clinic for sexually transmitted diseases
    • Srugo, I. et al. Agents of non-gonococcal urethritis in males attending an Israeli clinic for sexually transmitted diseases. Isr Med Assoc J 5, 24-27 (2003).
    • (2003) Isr Med Assoc J , vol.5 , pp. 24-27
    • Srugo, I.1
  • 14
    • 31044454940 scopus 로고    scopus 로고
    • Etiologies of nongonococcal urethritis: Bacteria, viruses, and the association with orogenital exposure
    • Bradshaw, C.S. et al. Etiologies of nongonococcal urethritis: bacteria, viruses, and the association with orogenital exposure. J Infect Dis 193, 336-345 (2006).
    • (2006) J Infect Dis , vol.193 , pp. 336-345
    • Bradshaw, C.S.1
  • 16
    • 0033575489 scopus 로고    scopus 로고
    • Induction of mucosal antibody responses by micro-sphere-encapsulated formalin-inactivated simian immunodeficiency virus in a male urethral challenge model
    • Ishizaka, S.T. et al. Induction of mucosal antibody responses by micro-sphere-encapsulated formalin-inactivated simian immunodeficiency virus in a male urethral challenge model. Vaccine 17, 2817-2825 (1999).
    • (1999) Vaccine , vol.17 , pp. 2817-2825
    • Ishizaka, S.T.1
  • 17
    • 0024464463 scopus 로고
    • Genital mucosal transmission of simian immunodeficiency virus: Animal model for heterosexual transmission of human immunodeficiency virus
    • Miller, C.J. et al. Genital mucosal transmission of simian immunodeficiency virus: animal model for heterosexual transmission of human immunodeficiency virus. J Virol 63, 4277-4284 (1989).
    • (1989) J Virol , vol.63 , pp. 4277-4284
    • Miller, C.J.1
  • 18
    • 82455198719 scopus 로고    scopus 로고
    • SIVmac251 is inefficiently transmitted to rhesus macaques by penile inoculation with a single SIVenv variant found in ramp-up phase plasma
    • Ma, Z.M. et al. SIVmac251 is inefficiently transmitted to rhesus macaques by penile inoculation with a single SIVenv variant found in ramp-up phase plasma. AIDS Res Hum Retroviruses 27, 1259-1269 (2011).
    • (2011) AIDS Res Hum Retroviruses , vol.27 , pp. 1259-1269
    • Ma, Z.M.1
  • 19
    • 33746211644 scopus 로고    scopus 로고
    • Potential HIV-1 target cells in the human penis
    • McCoombe, S.G. & Short, R.V. Potential HIV-1 target cells in the human penis. Aids 20, 1491-1495 (2006).
    • (2006) Aids , vol.20 , pp. 1491-1495
    • McCoombe, S.G.1    Short, R.V.2
  • 20
    • 59849108852 scopus 로고    scopus 로고
    • HIV-1 infection of human penile explant tissue and protection by candidate microbicides
    • Fischetti, L., Barry, S.M., Hope, T.J. & Shattock, R.J. HIV-1 infection of human penile explant tissue and protection by candidate microbicides. AIDS 23, 319-328 (2009).
    • (2009) AIDS , vol.23 , pp. 319-328
    • Fischetti, L.1    Barry, S.M.2    Hope, T.J.3    Shattock, R.J.4
  • 21
    • 24044497019 scopus 로고    scopus 로고
    • HIV coreceptor and chemokine ligand gene expression in the male urethra and female cervix
    • McClure, C.P. etal. HIV coreceptor and chemokine ligand gene expression in the male urethra and female cervix. AIDS 19, 1257-1265 2005).
    • (2005) AIDS , vol.19 , pp. 1257-1265
    • McClure, C.P.1
  • 22
    • 0036793294 scopus 로고    scopus 로고
    • Diversity of receptors binding HIV on dendritic cell subsets
    • Turville, S.G. et al. Diversity of receptors binding HIV on dendritic cell subsets. Nat Immunol 3, 975-983 (2002).
    • (2002) Nat Immunol , vol.3 , pp. 975-983
    • Turville, S.G.1
  • 23
    • 0033984930 scopus 로고    scopus 로고
    • Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules
    • Valladeau, J. et al. Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity 12, 71-81 (2000).
    • (2000) Immunity , vol.12 , pp. 71-81
    • Valladeau, J.1
  • 24
    • 77951630373 scopus 로고    scopus 로고
    • GP41-specific antibody blocks cell-free HIV type 1 transcytosis through human rectal mucosa and model colonic epithelium
    • Shen, R. et al. GP41-specific antibody blocks cell-free HIV type 1 transcytosis through human rectal mucosa and model colonic epithelium. J Immunol 184, 3648-3655 (2010).
    • (2010) J Immunol , vol.184 , pp. 3648-3655
    • Shen, R.1
  • 25
    • 0031023496 scopus 로고    scopus 로고
    • Transcytosis of infectious human immunodeficiency virus across a tight human epithelial cell line barrier
    • Bomsel, M. Transcytosis of infectious human immunodeficiency virus across a tight human epithelial cell line barrier. Nat Med 3, 42-47 (1997).
    • (1997) Nat Med , vol.3 , pp. 42-47
    • Bomsel, M.1
  • 26
    • 2142730100 scopus 로고    scopus 로고
    • Central memory and effector memory Tcell subsets: Function, generation, and maintenance
    • Sallusto, F., Geginat, J. & Lanzavecchia, A. Central memory and effector memory Tcell subsets: function, generation, and maintenance. Annu Rev Immunol 22, 745-763 (2004).
    • (2004) Annu Rev Immunol , vol.22 , pp. 745-763
    • Sallusto, F.1    Geginat, J.2    Lanzavecchia, A.3
  • 27
    • 79956119017 scopus 로고    scopus 로고
    • Regional and mucosal memory T cells
    • Sheridan, B.S. & Lefrancois, L. Regional and mucosal memory T cells. Nat Immunol 12, 485-491 (2011).
    • (2011) Nat Immunol , vol.12 , pp. 485-491
    • Sheridan, B.S.1    Lefrancois, L.2
  • 28
    • 0036776324 scopus 로고    scopus 로고
    • Memory CD4(+) Tcells are the earliest detectable human immunodeficiency virus type 1 (HIV-1)-infected cells in the female genital mucosal tissue during HIV-1 transmission in an organ culture system
    • Gupta, P. et al. Memory CD4(+) Tcells are the earliest detectable human immunodeficiency virus type 1 (HIV-1)-infected cells in the female genital mucosal tissue during HIV-1 transmission in an organ culture system. J Virol 76, 9868-9876 (2002).
    • (2002) J Virol , vol.76 , pp. 9868-9876
    • Gupta, P.1
  • 29
    • 17844376742 scopus 로고    scopus 로고
    • Peak SIV replication in resting memory CD4+ Tcells depletes gut lamina propria CD4 + T cells
    • Li, Q. et al. Peak SIV replication in resting memory CD4+ Tcells depletes gut lamina propria CD4 + T cells. Nature 434, 1148-1152 (2005).
    • (2005) Nature , vol.434 , pp. 1148-1152
    • Li, Q.1
  • 30
    • 79958184404 scopus 로고    scopus 로고
    • Stromal down-regulation of macrophage CD4/CCR5 expression and NF-kappaB activation mediates HIV-1 non-permissiveness in intestinal macrophages
    • Shen, R. et al. Stromal down-regulation of macrophage CD4/CCR5 expression and NF-kappaB activation mediates HIV-1 non-permissiveness in intestinal macrophages. PLoS Pathog 7, e10020602011).
    • (2011) PLoS Pathog , vol.7
    • Shen, R.1
  • 31
    • 70350148394 scopus 로고    scopus 로고
    • Understanding HIV-1 latency provides clues for the eradication of longterm reservoirs
    • Coiras, M., Lopez-Huertas, M.R., Perez-Olmeda, M. & Alcami, J. Understanding HIV-1 latency provides clues for the eradication of longterm reservoirs. Nat Rev Microbiol 7, 798-812 (2009).
    • (2009) Nat Rev Microbiol , vol.7 , pp. 798-812
    • Coiras, M.1    Lopez-Huertas, M.R.2    Perez-Olmeda, M.3    Alcami, J.4
  • 32
    • 74349122226 scopus 로고    scopus 로고
    • HIV infection of the male genital tract-consequences for sexual transmission and reproduction
    • Le Tortorec, A. & Dejucq-Rainsford, N. HIV infection of the male genital tract-consequences for sexual transmission and reproduction. Int J Androl 33, e98-e108 (2010).
    • (2010) Int J Androl , vol.33
    • Le Tortorec, A.1    Dejucq-Rainsford, N.2
  • 33
    • 74249104684 scopus 로고    scopus 로고
    • Targeting Trojan Horse leukocytes for HIV prevention
    • Anderson, D.J. et al. Targeting Trojan Horse leukocytes for HIV prevention. Aids 24, 163-187 (2010).
    • (2010) Aids , vol.24 , pp. 163-187
    • Anderson, D.J.1
  • 34
    • 44649102135 scopus 로고    scopus 로고
    • Identification and characterization of transmitted and early founder virus envelopes inprimary HIV-1 infection
    • Keele, B.F. et al. Identification and characterization of transmitted and early founder virus envelopes inprimary HIV-1 infection. Proc Natl Acad Sci USA 105, 7552-7557 (2008).
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 7552-7557
    • Keele, B.F.1
  • 35
    • 79951754740 scopus 로고    scopus 로고
    • Immunization with HIV-1 gp41 subunit virosomes induces mucosal antibodies protecting nonhuman primates against vaginal SHIV challenges
    • Bomsel, M. etal. Immunization with HIV-1 gp41 subunit virosomes induces mucosal antibodies protecting nonhuman primates against vaginal SHIV challenges. Immunity 34, 269-280 (2011).
    • (2011) Immunity , vol.34 , pp. 269-280
    • Bomsel, M.1
  • 36
    • 0036785656 scopus 로고    scopus 로고
    • Immortalizationof human urethral epithelial cells: A model for the study of the pathogenesis of and the inflammatory cytokine response to Neisseria gonorrhoeae infection
    • Harvey, H.A., Post, D.M. & Apicella, M.A. Immortalizationof human urethral epithelial cells: a model for the study of the pathogenesis of and the inflammatory cytokine response to Neisseria gonorrhoeae infection. Infect Immun 70, 5808-5815 (2002).
    • (2002) Infect Immun , vol.70 , pp. 5808-5815
    • Harvey, H.A.1    Post, D.M.2    Apicella, M.A.3
  • 37
    • 8444246266 scopus 로고    scopus 로고
    • Involvement of Fc gamma RI (CD64) in the mechanism of HIV-1 inhibition by polyclonal IgG purified from infected patients in cultured monocyte-derived macrophages
    • Holl, V. et al. Involvement of Fc gamma RI (CD64) in the mechanism of HIV-1 inhibition by polyclonal IgG purified from infected patients in cultured monocyte-derived macrophages. J Immunol 173, 6274-6283 (2004).
    • (2004) J Immunol , vol.173 , pp. 6274-6283
    • Holl, V.1
  • 38
    • 0035027404 scopus 로고    scopus 로고
    • Cell-to-cell contact results in a selective translocation of maternal human immunodeficiency virus type 1 quasispecies across a trophoblastic barrier by both transcytosis and infection
    • Lagaye, S. et al. Cell-to-cell contact results in a selective translocation of maternal human immunodeficiency virus type 1 quasispecies across a trophoblastic barrier by both transcytosis and infection. J Virol 75, 4780-4791 (2001).
    • (2001) J Virol , vol.75 , pp. 4780-4791
    • Lagaye, S.1
  • 39
    • 10244225287 scopus 로고    scopus 로고
    • Dynamics and modulation of human immunodeficiency virus type 1 transcripts in vitro and in vivo
    • Bagnarelli, P. et al. Dynamics and modulation of human immunodeficiency virus type 1 transcripts in vitro and in vivo. J Virol 70, 7603-7613 (1996).
    • (1996) J Virol , vol.70 , pp. 7603-7613
    • Bagnarelli, P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.