Simvastatin prevents proliferation and bone metastases of lung adenocarcinoma in vitro and in vivo

Neoplasma

Volumn 60, Issue 3, 2013, Pages 240-246

  Liu, H ^a   Wang, Z ^a   Li, Y ^a   Li, W ^a   Chen, Y ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Bone metastases; CD44; Lung carcinoma; MAPK ERK; P53; Simvastatin

Indexed keywords

GELATINASE A; GELATINASE B; HERMES ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; PROTEIN P53; RAF PROTEIN; SIMVASTATIN; 3 HYDROXY 3 METHYLGLUTARYL COENZYME A; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A; ACYL COENZYME A; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MESSENGER RNA; TUMOR MARKER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BONE METASTASIS; CELL MIGRATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG ADENOCARCINOMA; MOUSE; NONHUMAN; PHOSPHORYLATION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR INVASION; WESTERN BLOTTING; ADENOCARCINOMA; ANIMAL; APOPTOSIS; BAGG ALBINO MOUSE; BONE TUMOR; CELL PROLIFERATION; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; LUNG TUMOR; METABOLISM; METASTASIS; NUDE MOUSE; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL CULTURE;

ACYL COENZYME A; ADENOCARCINOMA; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BONE NEOPLASMS; CELL PROLIFERATION; FEMALE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LUNG NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, NUDE; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIMVASTATIN; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

MLCS; MLOWN;

EID: 84879354095     PISSN: 00282685     EISSN: 13384317     Source Type: Journal    
DOI: 10.4149/neo_2013_032     Document Type: Article

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