Atrial fibrillation promotion by endurance exercise: Demonstration and mechanistic exploration in an animal model

Journal of the American College of Cardiology

Volumn 62, Issue 1, 2013, Pages 68-77

  Guasch, Eduard ^a,b   Benito, Begoña ^a,b,c   Qi, Xiaoyan ^a   Cifelli, Carlo ^d   Naud, Patrice ^a   Shi, Yanfen ^a   Mighiu, Alexandra ^d   Tardif, Jean Claude ^a   Tadevosyan, Artavazd ^a   Chen, Yu ^a   Gillis, Marc Antoine ^a   Iwasaki, Yu Ki ^a   Dobrev, Dobromir ^e   Mont, Lluis ^b,d   Heximer, Scott ^d   Nattel, Stanley ^a  

^a MONTREAL HEART INSTITUTE   (Canada)

^b UNIVERSITY OF BARCELONA   (Spain)

^c HOSPITAL DEL MAR   (Spain)

^d UNIVERSITY OF TORONTO   (Canada)

^e UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

arrhythmia mechanisms; exercise training; ion currents; potassium channel

Indexed keywords

MESSENGER RNA; RGS PROTEIN; RGS4 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTONOMIC NERVOUS SYSTEM; CONTROLLED STUDY; DISEASE PREDISPOSITION; DOWN REGULATION; ELECTROCARDIOGRAM; ENDURANCE TRAINING; GENE EXPRESSION; HEART ATRIUM FIBRILLATION; HEART MUSCLE FIBROSIS; HEART PACING; HEART RATE; HISTOPATHOLOGY; NONHUMAN; PARASYMPATHETIC TONE; PATCH CLAMP; POLYMERASE CHAIN REACTION; POTASSIUM CURRENT; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; SINUS RHYTHM; SITTING; TELEMETRY; TRANSTHORACIC ECHOCARDIOGRAPHY; TREADMILL EXERCISE;

ANIMALS; ATRIAL FIBRILLATION; DISEASE MODELS, ANIMAL; EXERCISE TEST; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHYSICAL CONDITIONING, ANIMAL; PHYSICAL ENDURANCE; RANDOM ALLOCATION; RATS; RATS, WISTAR;

EID: 84879352332     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2013.01.091     Document Type: Article

References (32)

1. P.R. Lawler, K.B. Filion, and M.J. Eisenberg Efficacy of exercise-based cardiac rehabilitation post-myocardial infarction: a systematic review and meta-analysis of randomized controlled trials Am Heart J 162 2011 571 584
2. G.A. La, C. Robberecht, and C. Kuiperi Lower than expected desmosomal gene mutation prevalence in endurance athletes with complex ventricular arrhythmias of right ventricular origin Heart 96 2010 1268 1274
3. B. Benito, G. Gay-Jordi, and A. Serrano-Mollar Cardiac arrhythmogenic remodeling in a rat model of long-term intensive exercise training Circulation 123 2011 13 22
4. L. Molina, L. Mont, and J. Marrugat Long-term endurance sport practice increases the incidence of lone atrial fibrillation in men: a follow-up study Europace 10 2008 618 623 (Pubitemid 351775294)
5. S. Baldesberger, U. Bauersfeld, and R. Candinas Sinus node disease and arrhythmias in the long-term follow-up of former professional cyclists Eur Heart J 29 2008 71 78
6. J. Grimsmo, I. Grundvold, S. Maehlum, and H. Arnesen High prevalence of atrial fibrillation in long-term endurance cross-country skiers: echocardiographic findings and possible predictors - a 28-30 years follow-up study Eur J Cardiovasc Prev Rehabil 17 2010 100 105
7. A. Aizer, J.M. Gaziano, N.R. Cook, J.E. Manson, J.E. Buring, and C.M. Albert Relation of vigorous exercise to risk of atrial fibrillation Am J Cardiol 103 2009 1572 1577
8. L. Mont, R. Elosua, and J. Brugada Endurance sport practice as a risk factor for atrial fibrillation and atrial flutter Europace 11 2009 11 17
9. Y.K. Iwasaki, K. Nishida, T. Kato, and S. Nattel Atrial fibrillation pathophysiology: implications for management Circulation 124 2011 2264 2274
10. S. Nattel From guidelines to bench: implications of unresolved clinical issues for basic investigations of atrial fibrillation mechanisms Can J Cardiol 27 2011 19 26
11. P. Boknik, S. Grote-Wessels, and G. Barteska Genetic disruption of G proteins, G(i2)alpha or G(o)alpha, does not abolish inotropic and chronotropic effects of stimulating muscarinic cholinoceptors in atrium Br J Pharmacol 158 2009 1557 1564
12. S. Nattel G-protein signaling and arrhythmogenic atrial remodeling: relevance to novel therapeutic targets in atrial fibrillation Heart Rhythm 6 2009 85 86
13. S. Gu, C. Cifelli, S. Wang, and S.P. Heximer RGS proteins: identifying new GAPs in the understanding of blood pressure regulation and cardiovascular function Clin Sci (Lond) 116 2009 391 399
14. C. Cifelli, R.A. Rose, and H. Zhang RGS4 regulates parasympathetic signaling and heart rate control in the sinoatrial node Circ Res 103 2008 527 535
15. R. Fagard Athlete's heart Heart 89 2003 1455 1461 (Pubitemid 37465249)
16. A. Pelliccia, B.J. Maron, and F.M. Di Paolo Prevalence and clinical significance of left atrial remodeling in competitive athletes J Am Coll Cardiol 46 2005 690 696 (Pubitemid 41132699)
17. R. Elosua, A. Arquer, and L. Mont Sport practice and the risk of lone atrial fibrillation: a case-control study Int J Cardiol 108 2006 332 337 (Pubitemid 43339799)
18. L. Liu, and S. Nattel Differing sympathetic and vagal effects on atrial fibrillation in dogs: role of refractoriness heterogeneity Am J Physiol 273 1997 H805 H816
19. C. Hoglund Enlarged left atrial dimension in former endurance athletes: an echocardiographic study Int J Sports Med 7 1986 133 136 (Pubitemid 16091924)
20. A. Pelliccia, B.J. Maron, L.R. De, F.M. Di Paolo, A. Spataro, and F. Culasso Remodeling of left ventricular hypertrophy in elite athletes after long-term deconditioning Circulation 105 2002 944 949 (Pubitemid 34184572)
21. H. Heidbuchel, W. Anne, R. Willems, B. Adriaenssens, F. Van de Werf, and H. Ector Endurance sports is a risk factor for atrial fibrillation after ablation for atrial flutter Int J Cardiol 107 2006 67 72 (Pubitemid 41767520)
22. B. Burstein, P. Comtois, and G. Michael Changes in connexin expression and the atrial fibrillation substrate in congestive heart failure Circ Res 105 2009 1213 1222
23. L. Yue, J. Xie, and S. Nattel Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation Cardiovasc Res 89 2011 744 753
24. D. Li, S. Fareh, T.K. Leung, and S. Nattel Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a different sort Circulation 100 1999 87 95 (Pubitemid 29297945)
25. S. Verheule, T. Sato, and T. Everett Increased vulnerability to atrial fibrillation in transgenic mice with selective atrial fibrosis caused by overexpression of TGF-beta1 Circ Res 94 2004 1458 1465 (Pubitemid 38780318)
26. L. Mont, A. Sambola, and J. Brugada Long-lasting sport practice and lone atrial fibrillation Eur Heart J 23 2002 477 482 (Pubitemid 35204187)
27. S.R. Collier, J.A. Kanaley, and R. Carhart Jr. Cardiac autonomic function and baroreflex changes following 4 weeks of resistance versus aerobic training in individuals with pre-hypertension Acta Physiol (Oxf) 195 2009 339 348
28. M. Pietila, K. Malminiemi, and R. Vesalainen Exercise training in chronic heart failure: beneficial effects on cardiac (11)C-hydroxyephedrine PET, autonomic nervous control, and ventricular repolarization J Nucl Med 43 2002 773 779 (Pubitemid 34663299)
29. Y. Fu, X. Huang, H. Zhong, R.M. Mortensen, L.G. D'Alecy, and R.R. Neubig Endogenous RGS proteins and Galpha subtypes differentially control muscarinic and adenosine-mediated chronotropic effects Circ Res 98 2006 659 666
30. K. Bender, P. Nasrollahzadeh, M. Timpert, B. Liu, L. Pott, and M.C. Kienitz A role for RGS10 in beta-adrenergic modulation of G-protein-activated K+ (GIRK) channel current in rat atrial myocytes J Physiol 586 2008 2049 2060 (Pubitemid 351524562)
31. G. Laroche, P.M. Giguere, B.L. Roth, J. Trejo, and D.P. Siderovski RNA interference screen for RGS protein specificity at muscarinic and protease-activated receptors reveals bidirectional modulation of signaling Am J Physiol Cell Physiol 299 2010 C654 C664
32. B.E. Ainsworth, W.L. Haskell, and M.C. Whitt Compendium of physical activities: an update of activity codes and MET intensities Med Sci Sports Exerc 32 2000 S498 S504