Genome-wide RNAi screen reveals a role for the ESCRT complex in rotavirus cell entry

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 25, 2013, Pages 10270-10275

  Silva Ayala, Daniela ^a   López, Tomás ^a   Gutiérrez, Michelle ^a   Perrimon, Norbert ^a   López, Susana ^b   Arias, Carlos F ^a   Estes, Mary K ^a  

^a INSTITUTO DE BIOTECNOLOGÍA   (Mexico)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ALPHA ACTININ 4; CLATHRIN; EARLY ENDOSOME ANTIGEN 1; ESCRT PROTEIN; GUANOSINE TRIPHOSPHATASE; PHOSPHOLIPID; RNA;

ARTICLE; CELL VACUOLE; CONTROLLED STUDY; ENDOCYTOSIS; EPITHELIUM CELL; GENOME ANALYSIS; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; ROTAVIRUS; ROTAVIRUS INFECTION; VIRUS ENTRY; VIRUS STRAIN;

ANIMALS; CACO-2 CELLS; CDC42 GTP-BINDING PROTEIN; CERCOPITHECUS AETHIOPS; ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT; GENOME-WIDE ASSOCIATION STUDY; HUMANS; PROTEIN TRANSPORT; RAB GTP-BINDING PROTEINS; RAB5 GTP-BINDING PROTEINS; RHOA GTP-BINDING PROTEIN; RNA INTERFERENCE; ROTAVIRUS; ROTAVIRUS INFECTIONS; TRANSPORT VESICLES; VACUOLAR PROTON-TRANSLOCATING ATPASES; VERO CELLS; VESICULAR TRANSPORT PROTEINS;

ROTAVIRUS; SIMIAE;

EID: 84879316242     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1304932110     Document Type: Article

References (35)

1. Parashar U, et al. (2013) Progress with rotavirus vaccines: Summary of the Tenth International Rotavirus Symposium. Expert Rev Vaccines 12(2):113-117.
2. Estes MK, Kapikian AZ (2007) Fields Virology, eds Knipe DM, Howley PM (Lippincott William & Wilkins, Philadelphia), pp 1917-1974.
3. Crawford SE, Hyser JM, Utama B, Estes MK (2012) Autophagy hijacked through viroporin-activated calcium/calmodulin-dependent kinase kinase-β signaling is required for rotavirus replication. Proc Natl Acad Sci USA 109(50):E3405-E3413.
4. Martínez MA, López S, Arias CF, Isa P (2013) Gangliosides have a functional role during rotavirus cell entry. J Virol 87(2):1115-1122.
5. Huang P, et al. (2012) Spike protein VP8* of human rotavirus recognizes histo-blood group antigens in a type-specific manner. J Virol 86(9):4833-4843.
6. Hu L, et al. (2012) Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen. Nature 485(7397):256-259.
7. López S, Arias CF (2004) Multistep entry of rotavirus into cells: A Versaillesque dance. Trends Microbiol 12(6):271-278.
8. Gutiérrez M, et al. (2010) Different rotavirus strains enter MA104 cells through different endocytic pathways: The role of clathrin-mediated endocytosis. J Virol 84(18):9161-9169.
9. Wolf M, Vo PT, Greenberg HB (2011) Rhesus rotavirus entry into a polarized epithelium is endocytosis dependent and involves sequential VP4 conformational changes. J Virol 85(6):2492-2503.
10. Wolf M, Deal EM, Greenberg HB (2012) Rhesus rotavirus trafficking during entry into MA104 cells is restricted to the early endosome compartment. J Virol 86(7):4009-4013.
11. Díaz-Salinas MA, et al. (2013) The spike protein VP4 defines the endocytic pathway used by rotavirus to enter MA104 cells. J Virol 87(3):1658-1663.
12. Yoder JD, et al. (2009) VP5 rearranges when rotavirus uncoats. J Virol 83(21):11372-11377.
13. Mohr S, Bakal C, Perrimon N (2010) Genomic screening with RNAi: Results and challenges. Annu Rev Biochem 79:37-64.
14. López T, Silva-Ayala D, López S, Arias CF (2012) Methods suitable for high-throughput screening of siRNAs and other chemical compounds with the potential to inhibit rotavirus replication. J Virol Methods 179(1):242-249.
15. Wollert T, Hurley JH (2010) Molecular mechanism of multivesicular body biogenesis by ESCRT complexes. Nature 464(7290):864-869.
16. Nava P, López S, Arias CF, Islas S, González-Mariscal L (2004) The rotavirus surface protein VP8 modulates the gate and fence function of tight junctions in epithelial cells. J Cell Sci 117(Pt 23):5509-5519.
17. Dong Y, Zeng CQ, Ball JM, Estes MK, Morris AP (1997) The rotavirus enterotoxin NSP4 mobilizes intracellular calcium in human intestinal cells by stimulating phospholipase C-mediated inositol 1, 4, 5-trisphosphate production. Proc Natl Acad Sci USA 94(8):3960-3965.
18. Contin R, Arnoldi F, Mano M, Burrone OR (2011) Rotavirus replication requires a functional proteasome for effective assembly of viroplasms. J Virol 85(6):2781-2792.
19. López T, Silva-Ayala D, López S, Arias CF (2011) Replication of the rotavirus genome requires an active ubiquitin-proteasome system. J Virol 85(22):11964-11971.
20. Bergelson JM (2009) Intercellular junctional proteins as receptors and barriers to virus infection and spread. Cell Host Microbe 5(6):517-521.
21. Chemello ME, Aristimuño OC, Michelangeli F, Ruiz MC (2002) Requirement for vacuolar H+ -ATPase activity and Ca2+ gradient during entry of rotavirus into MA104 cells. J Virol 76(24):13083-13087.
22. Huotari J, Helenius A (2011) Endosome maturation. EMBO J 30(17):3481-3500.
23. Pasqual G, Rojek JM, Masin M, Chatton JY, Kunz S (2011) Old world arenaviruses enter the host cell via the multivesicular body and depend on the endosomal sorting complex required for transport. PLoS Pathog 7(9):e1002232.
24. Taylor MP, Koyuncu OO, Enquist LW (2011) Subversion of the actin cytoskeleton during viral infection. Nat Rev Microbiol 9(6):427-439.
25. Zambrano JL, et al. (2012) Rotavirus infection of cells in culture induces activation of RhoA and changes in the actin and tubulin cytoskeleton. PLoS ONE 7(10):e47612.
26. van Meel E, Klumperman J (2008) Imaging and imagination: Understanding the endolysosomal system. Histochem Cell Biol 129(3):253-266.
27. Matsuo H, et al. (2004) Role of LBPA and Alix in multivesicular liposome formation and endosome organization. Science 303(5657):531-534.
28. Karjalainen M, et al. (2011) Echovirus 1 infection depends on biogenesis of novel multivesicular bodies. Cell Microbiol 13(12):1975-1995.
29. Petiot A, et al. (2008) Alix differs from ESCRT proteins in the control of autophagy. Biochem Biophys Res Commun 375(1):63-68.
30. Lobert VH, et al. (2010) Ubiquitination of alpha 5 beta 1 integrin controls fibroblast migration through lysosomal degradation of fibronectin-integrin complexes. Dev Cell 19(1):148-159.
31. Rollo EE, et al. (1999) The epithelial cell response to rotavirus infection. J Immunol 163(8):4442-4452.
32. Holloway G, Coulson BS (2006) Rotavirus activates JNK and p38 signaling pathways in intestinal cells, leading to AP-1-driven transcriptional responses and enhanced virus replication. J Virol 80(21):10624-10633.
33. Dobrowolski R, De Robertis EM (2012) Endocytic control of growth factor signalling: Multivesicular bodies as signalling organelles. Nat Rev Mol Cell Biol 13(1):53-60.
34. Kozik P, et al. (2013) A human genome-wide screen for regulators of clathrin-coated vesicle formation reveals an unexpected role for the V-ATPase. Nat Cell Biol 15(1):50-60.
35. Trask SD, Kim IS, Harrison SC, Dormitzer PR (2010) A rotavirus spike protein conformational intermediate binds lipid bilayers. J Virol 84(4):1764-1770.